US4201216A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Absorbable coating composition for sutures
Assignee: Ethicon Inc
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Filing: 1979-02-09
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Granted: 1980-05-06
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Expires: 1999-02-09
Abstract
Abstract The tie-down properties of multifilament surgical sutures are improved by coating the suture with an absorbable composition comprising a mixture of from about 1 to 4 parts of an absorbable, film-forming polymer, and 1 to 4 parts of a substantially water-insoluble salt of a C 6 or higher fatty acid. Braided sutures coated with from 2 to 10 percent by weight of the composition are characterized by a smooth knot tie-down under both wet and dry conditions.
Inventors
- 👤 Frank V. Mattei
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 20:07
CPC Classifications
A; A61; A61L; A61L17/00; A61L17/14; A61L17/145; A61L17/06; A61L17/10; C; C10; C10M; C10M111/00; C10M111/04; C10M2205/00; C10M2205/17; C10M2205/173; C10M2207/00; C10M2207/10; C10M2207/12; C10M2207/125; C10M2207/129; C10M2209/00; C10M2209/02; C10M2209/04; C10M2209/06; C10M2209/062; C10M2209/08; C10M2209/082; C10M2209/10; C10M2209/102; C10M2209/103; C10M2209/104; C10M2209/12; C10M2217/00; C10M2217/02; C10M2217/024; C10M2217/028; C10M2217/04; C10M2217/044; C10M2217/045; C10M2217/06; C10N; C10N2010/00; C10N2010/04; C10N2010/06; C10N2040/00; C10N2040/46; C10N2050/00; C10N2050/015; C10N2050/02
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
69 words
A synthetic, absorbable, multifilament suture having improved and substantially equal dry and wet tie-down properties, said suture being coated with from about 2 to 15 percent by weight of a composition comprising a mixture of a substantially water-insoluble, absorbable salt of a C 6 or higher fatty acid and an absorbable, film-forming polymer, the ratio of said fatty acid salt to said polymer being from about 1:4 to 4:1.
Claim 2
Dependent Claim
69 words
A synthetic, absorbable, multifilament suture having improved and substantially equal dry and wet tie-down properties, said suture being coated with from about 2 to 15 percent by weight of a composition comprising a mixture of a substantially water-insoluble, absorbable salt of a C 6 or higher fatty acid and an absorbable, film-forming polymer, the ratio of said fatty acid salt to said polymer being from about 1:4 to 4:1.
Claim 3
Dependent Claim
20 words
A suture of claim 1, wherein the fatty acid salt is the salt of calcium, magnesium, barium, aluminum, or zinc.
Claim 4
Dependent Claim
27 words
A suture of claim 1, wherein said higher fatty acid is selected from the group consisting of C 12 to C 22 fatty acids and mixtures thereof.
Claim 5
Dependent Claim
17 words
A suture of claim 3, wherein the fatty acid salt is the salt of calcium or magnesium.
Claim 6
Dependent Claim
17 words
A suture of claim 4, wherein the fatty acid comprises a mixture of stearic and palmitic acid.
Claim 7
Dependent Claim
60 words
A suture of claim 1, wherein said film-forming polymer is selected from the group consisting of homopolymers and copolymers of poly(p-dioxanone), poly(alkylene oxalate), lactide, and glycolide, copolymers of vinyl acetate with unsaturated carboxylic acids, water soluble or dispersible cellulose derivatives, natural gums, ethylene oxide polymers, polyacrylamide, polyvinyl alcohol, polyvinyl pyrrolidone, gelatin, collagen, polyamino acids, conjugated unsaturated triglycerides, and mixtures thereof.
Claim 8
Dependent Claim
26 words
A suture of claim 1, wherein said film-forming polymer is a copolymer of lactide and glycolide containing from about 15 to 85 mole percent dilactyl units.
Claim 9
Dependent Claim
30 words
A suture of claim 7, wherein said lactide/glycolide copolymer has an inherent viscosity of from about 0.5 to 4.0 measured as a 0.1 percent solution in hexafluoroisopropanol at 25° C.
Claim 10
Dependent Claim
16 words
A suture of claim 8, wherein the lactide/glycolide copolymer contains about 65 mole percent dilactyl units.
Claim 11
Dependent Claim
19 words
A suture of claim 9, wherein the fatty acid salt comprises a mixture of calcium palmitate and calcium stearate.
Claim 12
Dependent Claim
22 words
A suture of claim 10, wherein the ratio of the fatty acid salt to lactide/glycolide polymer is between about 1:2 and 2:1.
Claim 13
Dependent Claim
17 words
A suture of claim 11, coated with from about 5 to 10 percent of the said mixture.
Claim 14
Dependent Claim
20 words
A suture of claim 1, wherein the synthetic absorbable suture is comprised of homopolymers or copolymers of lactide and glycolide.
Claim 15
Dependent Claim
23 words
A suture of claim 13, wherein said suture is comprised of a copolymer of 10 weight percent lactide and 90 weight percent glycolide.
Claim 16
Dependent Claim
13 words
A suture of claim 14, wherein the multifilament suture is a braided suture.
Claim 17
Dependent Claim
14 words
A suture of claim 1, wherein the synthetic absorbable suture is composed of poly(p-dioxanone).
Claim 18
Dependent Claim
13 words
A suture of claim 16, wherein the multifilament suture is a braided suture.
Claim 19
Dependent Claim
12 words
The method of claim 17, wherein said suture is composed of poly(p-dioxanone).
Claim 20
Independent Claim
92 words
A method for imparting improved and substantially equal dry and wet tie-down properties to a multifilament suture which comprises coating said suture with from about 2 to 15 percent by weight on a dry basis of a composition comprising a mixture of a substantially water-insoluble, absorbable salt of a C 6 or higher fatty acid and an absorbable, film-forming polymer in a volatile solvent, the ratio of said fatty acid salt to said polymer being from about 1:4 to 4:1, and thereafter drying said coated suture to remove substantially all the solvent.
Claim 21
Independent Claim
92 words
A method for imparting improved and substantially equal dry and wet tie-down properties to a multifilament suture which comprises coating said suture with from about 2 to 15 percent by weight on a dry basis of a composition comprising a mixture of a substantially water-insoluble, absorbable salt of a C 6 or higher fatty acid and an absorbable, film-forming polymer in a volatile solvent, the ratio of said fatty acid salt to said polymer being from about 1:4 to 4:1, and thereafter drying said coated suture to remove substantially all the solvent.
Claim 22
Dependent Claim
20 words
The method of claim 19, wherein the fatty acid salt is the salt of calcium, magnesium, barium, aluminum, or zinc.
Claim 23
Dependent Claim
27 words
The method of claim 19, wherein said higher fatty acid is selected from the group consisting of C 12 to C 22 fatty acids and mixtures thereof.
Claim 24
Dependent Claim
59 words
The method of claim 19, wherein said film-forming polymer is selected from the group consisting of homopolymers and copolymers of poly(p-dioxanone), poly(alkylene oxalate), lactide and glycolide, copolymers of vinyl acetate with unsaturated carboxylic acids, water soluble or dispersible cellulose derivatives, natural gums, ethylene oxide polymers, polyacrylamide, polyvinyl alcohol, polyvinyl pyrrolidone, gelatin, collagen, polyamino acids, conjugated triglycerides, and mixtures thereof.
Claim 25
Dependent Claim
28 words
The method of claim 19, wherein said suture is composed of an absorbable synthetic polymer selected from the group consisting of homopolymers and copolymers of lactide and glycolide.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-05-06 | 1983-11-05 | 1984-05-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-05-06 | 1987-11-05 | 1988-05-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-05-06 | 1991-11-05 | 1992-05-06 | $7700.00 | Window Closed / Lapsed |