US4879108A
Expired / Lapsed
US
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Confectionery delivery system for antipyretics
Assignee: Warner Lambert Co LLC
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Filing: 1988-10-14
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Granted: 1989-11-07
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Expires: 2008-10-14
Abstract
Abstract A chewable delivery system for actives comprising: (a) an active pre-coated with at least one material selected from the group consisting of lecithin, polyoxyalkylenes having chain lengths of about 4 carbons or less, glycerides having a melting point of 100 DEG C. or less, polyalkyleneglycols having a molecular weight of 3,700 or less, synthetic and natural waxes and mixtures thereof; and (b) a confectionery matrix comprising a binder system comprising gelatin and a humectant material selected from the group consisting of glycerin and its lower alkyl (C2-7) ester derivatives; a sweetener; and about 1% to about 30% by weight water.
Inventors
- 👤 Robert K. Yang
- 👤 Shri C. Sharma
- 👤 Shan-Shan Sheu
- 👤 James J. Shaw
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 17:22
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0053; A61K9/0056; A61K9/14; A61K9/16; A61K9/1605; A61K9/1617; A61K9/48; A61K9/50; A61K9/5005; A61K9/5015
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
120 words
A chewable confectionery delivery system for antipyretics comprising: (a) an antipyretic pre-coated with at least one material selected from the group consisting of lecithin, polyoxyalkylenes having chain lengths of about 4 carbons or less, glycerides having a melting point of 100° C. or less, polyalkyleneglycols having a molecular weight of 3,700 or less, synthetic and natural waxes and mixtures thereof; and (b) a confectionery matrix comprising a binder system comprising from about 0.1% to about 5% by weight gelatin and a humectant material selected from the group consisting of glycerin and its lower alkyl (C 2-7 ) ester derivatives, a sweetener; and about 1% to about 30% by weight water, all weights are in percent of the final delivery system.
Claim 2
Dependent Claim
120 words
A chewable confectionery delivery system for antipyretics comprising: (a) an antipyretic pre-coated with at least one material selected from the group consisting of lecithin, polyoxyalkylenes having chain lengths of about 4 carbons or less, glycerides having a melting point of 100° C. or less, polyalkyleneglycols having a molecular weight of 3,700 or less, synthetic and natural waxes and mixtures thereof; and (b) a confectionery matrix comprising a binder system comprising from about 0.1% to about 5% by weight gelatin and a humectant material selected from the group consisting of glycerin and its lower alkyl (C 2-7 ) ester derivatives, a sweetener; and about 1% to about 30% by weight water, all weights are in percent of the final delivery system.
Claim 3
Dependent Claim
33 words
The delivery system of claim 1 wherein the material used for the pre-coating of the active is present in amounts of about 1 to about 10% by weight of the total delivery system.
Claim 4
Dependent Claim
22 words
The delivery system of claim 1 wherein the ratio of coating to achive is about 1:3 to about 1:8 parts by weight.
Claim 5
Dependent Claim
32 words
The delivery system of claim 1 wherein the material used for the pre-coating of the active is selected from the group consisting of polyoxyethylene, polyoxypropylene, polyoxybutylene, copolymers of these and mixtures thereof.
Claim 6
Dependent Claim
22 words
The delivery system of claim 1 wherein the polyalkyleneglycol is selected from the group consisting of polyethyleneglycol, polyproplyleneglycol, polybutyleneglycol and mixtures thereof.
Claim 7
Dependent Claim
28 words
The delivery system of claim 1 wherein the binder system comprises about 0.1 to about 5.0% gelatin and about 0.1 to about ;b 25% of the humectant material.
Claim 8
Dependent Claim
22 words
The delivery system of claim 6 wherein the humectant is selected from the group consisting of glycerine, triacetin, tributyrin and mixtures thereof.
Claim 9
Dependent Claim
15 words
The delivery system of claim 1 wherein there is additionally incorporated a nonionic hydrocolloid gum.
Claim 10
Dependent Claim
24 words
The delivery system of claim 8 wherein the gum is selected from the group consisting of guar gum, locust bean gum, and mixtures thereof.
Claim 11
Dependent Claim
30 words
The delivery system of claim 1 wherein there is additionally included a material selected from the group consisting of pectin, sweeteners, flavoring, colorings, humectants, fillers, emulsifiers, thickeners, and mixtures thereof.
Claim 12
Dependent Claim
17 words
The delivery system of claim 1 wherein the pre-coated antipyretic is present in a pharmaceutically effective amount.
Claim 13
Dependent Claim
22 words
The delivery system of claim 1 wherein the pre-coated antipyretic comprises about 15 to about 30% by weight of the final product.
Claim 14
Dependent Claim
20 words
The delivery system of claim 1 wherein the antipyretic is selected from the group consisting of acetominophen, aspirin and ibuprofen.
Claim 15
Independent Claim
141 words
A method of preparing a confectionery delivery system for antipyretics comprising: (a) pre-coating the antipyretic with at least one material selected from the group consisting of lecithin, polyoxyalkylenes having a chain length of about 4 carbons or less, glycerides having a melting point of 100° C. or less, polyalkyleneglycols having a molecular weight of 3,700 or less, synthetic and natural waxes and mixtures thereof, wherein the coating does not interfere with the function or release of the active; and (b) preparing a confectionery matrix comprising the steps of (i) forming a solution of gelatin and a humectant selected from the group consisting of glycerin and its lower alkyl (C 2-7 ) ester derivatives; a sweetener; and about 1% to about 30% by weight water; and (c) admixing from (a) and (b) together; and (d) forming the resultant delivery system into shapes.
Claim 16
Independent Claim
141 words
A method of preparing a confectionery delivery system for antipyretics comprising: (a) pre-coating the antipyretic with at least one material selected from the group consisting of lecithin, polyoxyalkylenes having a chain length of about 4 carbons or less, glycerides having a melting point of 100° C. or less, polyalkyleneglycols having a molecular weight of 3,700 or less, synthetic and natural waxes and mixtures thereof, wherein the coating does not interfere with the function or release of the active; and (b) preparing a confectionery matrix comprising the steps of (i) forming a solution of gelatin and a humectant selected from the group consisting of glycerin and its lower alkyl (C 2-7 ) ester derivatives; a sweetener; and about 1% to about 30% by weight water; and (c) admixing from (a) and (b) together; and (d) forming the resultant delivery system into shapes.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-11-06 | 1993-05-08 | 1993-11-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-11-06 | 1997-05-08 | 1997-11-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-11-06 | 2001-05-08 | 2001-11-07 | $7700.00 | Window Closed / Lapsed |