US4841962A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Collagen matrix/polymer film composite dressing
Assignee: Medimatrix Inc
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Filing: 1987-09-11
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Granted: 1989-06-27
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Expires: 2007-09-11
Abstract
Abstract A wound dressing comprising a crosslinked collagen matrix; a bioabsorbable adhesive coated on one surface of the collagen matrix; a multilayer polymer film imparting pre-selected moisture vapor and gas transmissivity to the dressing, secured to the opposite surface of the collagen matrix; and an adhesive securing the collagen matrix to the polymer film.
Inventors
- 👤 Richard A. Berg
- 👤 Frederick H. Silver
- 👤 James M. Pachence
- 👤 John D'Antonio
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 04:03
CPC Classifications
C; C08; C08L; C08L89/00; C08L89/04; C08L89/06; A; A61; A61K; A61K9/00; A61K9/70; A61L; A61L15/00; A61L15/16; A61L15/22; A61L15/32; A61L15/325; A61L15/42; A61L15/44; A61L15/64; A61L27/00; A61L27/14; A61L27/22; A61L27/24; A61L27/50; A61L27/56; A61L27/58; A61L2300/00; A61L2300/20; A61L2300/23; A61L2300/232; A61L2300/252; A61L2300/40; A61L2300/412; Y; Y10; Y10S; Y10S128/00; Y10S128/08
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
176 words
A wound dressing to promote the progressive healing of a wound comprising: (a) a crosslinked collagen matrix; (b) a bioabsorbable adhesive coated on the surface of the collagen matrix to be placed in contact with the wound bed whereby the matrix affords epithelial and fibroblast cells in the bed with a scaffold on which to attach themselves and grow and the adhesive facilities wound healing; and (c) a multilayer polymer film secured to the opposite surface of the collagen matrix comprising a first layer having predetermined moisture and gas transmissivity characteristics appropriate to the wound to be healed superposed with the collagen matrix, and a second layer remote from the collagen matrix having relatively reduced moisture and gas transmissivity characteristics to render it more occlusive than the first layer to promote new cell growth in the early stages of wound healing, and strippable from the film after a period of time sufficient for the earlier stages of wound healing to take place to provide thereafter increased moisture vapor transmission between the wound bed and the atmosphere.
Claim 2
Dependent Claim
176 words
A wound dressing to promote the progressive healing of a wound comprising: (a) a crosslinked collagen matrix; (b) a bioabsorbable adhesive coated on the surface of the collagen matrix to be placed in contact with the wound bed whereby the matrix affords epithelial and fibroblast cells in the bed with a scaffold on which to attach themselves and grow and the adhesive facilities wound healing; and (c) a multilayer polymer film secured to the opposite surface of the collagen matrix comprising a first layer having predetermined moisture and gas transmissivity characteristics appropriate to the wound to be healed superposed with the collagen matrix, and a second layer remote from the collagen matrix having relatively reduced moisture and gas transmissivity characteristics to render it more occlusive than the first layer to promote new cell growth in the early stages of wound healing, and strippable from the film after a period of time sufficient for the earlier stages of wound healing to take place to provide thereafter increased moisture vapor transmission between the wound bed and the atmosphere.
Claim 3
Dependent Claim
19 words
The wound dressing of claim 1, wherein the collagen matrix is formed from Type I or Type III collagen.
Claim 4
Dependent Claim
44 words
The wound dressing of claim 2, wherein the collagen matrix comprises fibers defining surface and interior pores connected by internal channels, the average pore size being from 50 to 350 microns and the collagen comprising from 2 to 30% by volume of the matrix.
Claim 5
Dependent Claim
40 words
The wound dressing of claim 1, wherein the bioabsorbable adhesive is a material selected from the group consisting of polyisobutylenes, acrylic emulsions, polyvinyl ethyl ethers admixed with hydrogenated resin esters, natural rubber latex, collagen adhesives, and water based urethane emulsions.
Claim 6
Dependent Claim
24 words
The wound dressing of claim 4, wherein the bioabsorbable adhesive is polyisobutylene containing polyacrylamides, carboxymethylcellulose, starch graft copolymers, pectins, gelatins, resin esters or hydrocarbons.
Claim 7
Dependent Claim
80 words
The wound dressing of claim 1, wherein the second polymer layer which is farthest away from the collagen matrix permits from 0 to 500 g/cm 2 per 24 hours moisture transmission and from 500 to 6000 cm 3 m 2 -Atmos-24 hour oxygen permeation; whereas the first polymer layer closest to the collagen matrix permits from 500 to 5000 g/cm 2 per 24 hours moisture transmission and from 6000 to 20,000 cm 3 -m 2 - Atmos-24 hours oxygen permeation.
Claim 8
Dependent Claim
94 words
The wound dressing of claim 1, wherein the first polymer layer which is farthest away from the collagen matrix comprises a polymer selected from the group consisting of microporous polyether polyurethanes, polyester polyurethanes, microporous polyvinyl chlorides, polyolefins, cellulose acetate, polydifluroethylene, ethylene vinyl acetate, ionomeric films, silicone latex, biodegradable urethanes and acrylics; whereas the first polymer layer closest to the collagen matrix comprises a polymer selected from the group consisting of microporous polyether polyurethanes, polyester polyurethanes, microporous polyvinylchlorides, polyolefins, cellulose acetate, polydifluoroethylene, ethylene vinyl acetate, ionomeric films, silicone latex, biodegradable urethanes and acrylics and polyisobutylenes.
Claim 9
Dependent Claim
27 words
The wound dressing of claim 1, wherein the multilayer polymer film extends beyond the periphery of the collagen matrix for securing the dressing to surrounding, non-injured skin.
References Cited (Backward Citations)
US4060081A
Cited
US4703108A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-06-26 | 1992-12-26 | 1993-06-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-06-26 | 1996-12-26 | 1997-06-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-06-26 | 2000-12-26 | 2001-06-27 | $7700.00 | Window Closed / Lapsed |