US5001169A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Inductive collagen-based bone repair preparations
Assignee: Collagen Aesthetics Inc
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Filing: 1986-01-06
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Granted: 1991-03-19
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Expires: 2006-01-06
Abstract
Abstract A composition suitable for inductive bone implants is disclosed. The composition comprises a purified form of osteogenic factor in admixture with a carrier having a percentage of mineral carrier. The resulting implants are sufficiently hypoimmunogenic to be effective when implanted in xenogeneic hosts.
Inventors
- 👤 Ranga Nathan
- 👤 Saeid Seyedin
- 👤 Karl Piez
- 👤 Hanne Bentz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:36
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3641; A61L27/3645; A61L27/365; A61L27/14; A61L27/22; A61L27/227; A61L27/3604; A61L27/3608; C; C07; C07K; C07K14/00; C07K14/435; C07K14/475; C07K14/51; A61K; A61K38/00; A61L2430/00; A61L2430/02
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
61 words
A method of effecting bone repair in vertebrates in need of such treatment which comprises implanting into a bone defect a hypoimmunogenic composition which comprises an osteoinductively effective amount of a protein osteoinductive factor (OFE) derived from bone, which OFE is sufficiently pure to be hypoimmunogenic in a xenogeneic host, said composition containing at least 75% by weight of mineral carrier.
Claim 2
Independent Claim
61 words
A method of effecting bone repair in vertebrates in need of such treatment which comprises implanting into a bone defect a hypoimmunogenic composition which comprises an osteoinductively effective amount of a protein osteoinductive factor (OFE) derived from bone, which OFE is sufficiently pure to be hypoimmunogenic in a xenogeneic host, said composition containing at least 75% by weight of mineral carrier.
Claim 3
Independent Claim
85 words
A method of effecting bone repair in vertebrates in need of such treatment which comprises implanting into a bone defect a hypoimmunogenic composition which comprises an osteoinductively effective amount of a protein osteoinductive factor (OFE) derived from bone, which OFE is sufficiently pure to be hypoimmunogenic in a xenogeneic host which composition is 85-95% mineral carrier, 5-15% atelopeptide collagen, and wherein the amount of OFE corresponds to that obtained by including between about 0.5% and 4% by weight of the implant of partially purified OFE.
Claim 4
Independent Claim
85 words
A method of effecting bone repair in vertebrates in need of such treatment which comprises implanting into a bone defect a hypoimmunogenic composition which comprises an osteoinductively effective amount of a protein osteoinductive factor (OFE) derived from bone, which OFE is sufficiently pure to be hypoimmunogenic in a xenogeneic host which composition is 85-95% mineral carrier, 5-15% atelopeptide collagen, and wherein the amount of OFE corresponds to that obtained by including between about 0.5% and 4% by weight of the implant of partially purified OFE.
Claim 5
Independent Claim
82 words
A method of effecting bone repair in vertebrates in need of such treatment which comprises implanting into a bone defect a hypoimmunogenic composition which comprises an osteoinductively effective amount of a protein osteoinductive factor (OFE) derived from bone, which OFE is sufficiently pure to be hypoimmunogenic in a xenogeneic host, which composition is 87.5% TCP/HA mixture and 10% non-fibrillar collagen, and wherein the amount of OFE corresponds to that obtained by including 2.5% by weight of the implant as partially purified OFE.
Claim 6
Independent Claim
82 words
A method of effecting bone repair in vertebrates in need of such treatment which comprises implanting into a bone defect a hypoimmunogenic composition which comprises an osteoinductively effective amount of a protein osteoinductive factor (OFE) derived from bone, which OFE is sufficiently pure to be hypoimmunogenic in a xenogeneic host, which composition is 87.5% TCP/HA mixture and 10% non-fibrillar collagen, and wherein the amount of OFE corresponds to that obtained by including 2.5% by weight of the implant as partially purified OFE.
Claim 7
Independent Claim
83 words
A method of effecting bone repair in vertebrates in need of such treatment which comprises implanting into a bone defect a hypoimmunogenic composition which comprises an osteoinductively effective amount of a protein osteoinductive factor (OFE) derived from bone, which OFE is sufficiently pure to be hypoimmunogenic in a xenogeneic host, which composition is 91.5% TCP/HA mixture and 6% reconsitituted fibrillar collagen, and wherein the amount of OFE corresponds to that obtained by including 2.5% by weight of the implant as partially purified OFE.
Claim 8
Independent Claim
83 words
A method of effecting bone repair in vertebrates in need of such treatment which comprises implanting into a bone defect a hypoimmunogenic composition which comprises an osteoinductively effective amount of a protein osteoinductive factor (OFE) derived from bone, which OFE is sufficiently pure to be hypoimmunogenic in a xenogeneic host, which composition is 91.5% TCP/HA mixture and 6% reconsitituted fibrillar collagen, and wherein the amount of OFE corresponds to that obtained by including 2.5% by weight of the implant as partially purified OFE.
Claim 9
Dependent Claim
16 words
The method of claim 1 wherein the mineral carrier is selected from TCP/HA and mixtures thereof.
Claim 10
Dependent Claim
30 words
The method of claim 1 wherein the amount of OFE corresponds to that obtained by including between about 0.5% and 4% by weight of the implant of partially purified OFE.
Claim 11
Dependent Claim
16 words
The method of claim 2 wherein the mineral carrier is selected from TCP/HA and mixtures thereof.
Claim 12
Dependent Claim
12 words
The method of claim 2 wherein the atelopeptide collagen is nonfibrillar collagen.
Claim 13
Dependent Claim
13 words
The method of claim 2 wherein the atelopeptide collagen is reconstituted fibrillar collagen.
Claim 14
Dependent Claim
11 words
The method of claim 3 wherein the collagen is atelopeptide collagen.
Claim 15
Dependent Claim
11 words
The method of claim 4 wherein the collagen is atelopeptide collagen.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-03-18 | 1994-09-17 | 1995-03-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-03-18 | 1998-09-17 | 1999-03-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-03-18 | 2002-09-17 | 2003-03-19 | $7700.00 | Window Closed / Lapsed |