US4604379A
Expired / Lapsed
US
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Dialysis solutions containing cross-linked gelatin
Assignee: University of Missouri System
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Filing: 1984-06-18
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Granted: 1986-08-05
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Expires: 2004-06-18
Abstract
Abstract Peritoneal dialysis solution may have an osmotic agent as a partial or complete substitute to the conventional dextrose. The osmotic agent is gelatin chemically cross-linked to suppress gelation.
Inventors
- 👤 Zbylut J. Twardowski
- 👤 Karl D. Nolph
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:45
CPC Classifications
A; A61; A61K; A61K33/00; A61K38/00; A61K38/16; A61K38/17; A61K38/39; A61M; A61M1/00; A61M1/14; A61M1/28; A61M1/287; G; G03; G03C; G03C1/00; G03C1/005; G03C1/04; G03C1/047; G03C2001/0471
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
109 words
A peritoneal dialysis solution comprising an osmotic agent operative, when said solution is present in the peritoneal cavity, to induce and sustain the ultrafiltration of water from the blood into said solution through the peritoneum, said osmotic agent comprising gelatin which is chemically cross-linked to suppress gelatin and which has an isoelectric point at a pH below about 5, said cross-linked gelatin being essentially free of synthetically added, pendant ionizable groups, and a quantity of physiological cations present to maintain said solution at a pH above about 5 to create a normally anionic charge on said cross-linked gelatin and to cause said cross-linked gelatin to assume a salt form.
Claim 2
Dependent Claim
109 words
A peritoneal dialysis solution comprising an osmotic agent operative, when said solution is present in the peritoneal cavity, to induce and sustain the ultrafiltration of water from the blood into said solution through the peritoneum, said osmotic agent comprising gelatin which is chemically cross-linked to suppress gelatin and which has an isoelectric point at a pH below about 5, said cross-linked gelatin being essentially free of synthetically added, pendant ionizable groups, and a quantity of physiological cations present to maintain said solution at a pH above about 5 to create a normally anionic charge on said cross-linked gelatin and to cause said cross-linked gelatin to assume a salt form.
Claim 3
Dependent Claim
24 words
The peritoneal dialysis solution of claim 1 in which said physiological cations are selected from the group consisting of sodium, magnesium, potassium, and calcium.
Claim 4
Dependent Claim
22 words
The peritoneal dialysis solution of claim 1 in which said cross-linked gelatin is the reaction product of gelatin and an aliphatic diisocyanate.
Claim 5
Dependent Claim
21 words
The peritoneal dialysis solution of claim 1 in which said cross-linked gelatin is the reaction product of gelatin and dialdehyde glyoxal.
Claim 6
Dependent Claim
13 words
The peritoneal dialysis solution of claim 1 which has a pH of 6.0-7.5.
Claim 7
Dependent Claim
15 words
The peritoneal dialysis solution of claim 1 which contains dextrose as an added osmotic agent.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-08-04 | 1990-02-03 | 1990-08-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-08-04 | 1994-02-03 | 1994-08-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-08-04 | 1998-02-03 | 1998-08-05 | $7700.00 | Window Closed / Lapsed |