Patent US5308320A successfully refreshed from Google Patents.
US4803075A
Expired / Lapsed
US
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Injectable implant composition having improved intrudability
Assignee: Allergan Inc
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Filing: 1986-06-25
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Granted: 1989-02-07
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Expires: 2006-06-25
Abstract
Abstract Injectable aqueous suspensions of biomaterials, such as cross-linked collagen, that contain a biocompatible fluid lubricant, such as glycogen or maltose, are disclosed. The inclusion of the lubricant significantly improves the intrusion of the suspension into soft tissue.
Inventors
- 👤 Donald G. Wallace
- 👤 Hertsel Reihanian
- 👤 Bruce B. Pharriss
- 👤 William G. Braun
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:48
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/39; A61L; A61L27/00; A61L27/14; A61L27/22; A61L27/24; A61L27/26; A61L27/50; A61F; A61F2/00; A61F2/0059; A61F2310/00; A61F2310/00005; A61F2310/00365; A61L2400/00; A61L2400/06
Claims Analysis
Total Claims: 36
Claim 1
Independent Claim
73 words
An injectable implant composition for soft tissue augmentation comprising an aqueous suspension of a particulate biomaterial containing a sufficient amount of a biocompatible fluid lubricant to significantly improve the intrudability of the composition, wherein said particles of biomaterial are fibrils or beads comprising natural or synthetic polymers, and wherein said fluid lubricant comprises a non-fibrillar high molecular weight charged polymer, a high molecular weight neutral polymer, or a low molecular weight neutral molecule.
Claim 2
Dependent Claim
73 words
An injectable implant composition for soft tissue augmentation comprising an aqueous suspension of a particulate biomaterial containing a sufficient amount of a biocompatible fluid lubricant to significantly improve the intrudability of the composition, wherein said particles of biomaterial are fibrils or beads comprising natural or synthetic polymers, and wherein said fluid lubricant comprises a non-fibrillar high molecular weight charged polymer, a high molecular weight neutral polymer, or a low molecular weight neutral molecule.
Claim 3
Dependent Claim
21 words
The composition of claim 1 wherein the particulate biomaterial is fibrillar cross-linked collagen, or beads of a synthetic or natural polymer.
Claim 4
Dependent Claim
42 words
The composition of claim 1 wherein the particles of biomaterial are (a) generally spherical in shape and have diameters in the range of about 1 to 30 microns or (b) are 500-800 microns in length and less than 30 microns in width.
Claim 5
Dependent Claim
23 words
The composition of claim 1 wherein the concentration of particulate biomaterial in the suspension is in the range of 1% to 20% W/V.
Claim 6
Dependent Claim
23 words
The composition of claim 1 wherein the concentration of particulate biomaterial in the suspension is in the range of 3% to 6% W/V.
Claim 7
Dependent Claim
20 words
The composition of claim 1 wherein the concentration of said lubricant in the suspension is about 0.01% to 40% W/V.
Claim 8
Dependent Claim
12 words
The composition of claim 1 wherein the lubricant is a charged polymer.
Claim 9
Dependent Claim
17 words
The composition of claim 7 wherein the charged polymer is methylated collagen, succinylated collagen, or dextran sulfate.
Claim 10
Dependent Claim
35 words
The composition of claim 1 wherein the lubricant is an uncharged polymer selected from the group consisting of dextran, heparin, and glycogen, and the concentration of lubricant in the suspension is 10% to 40% W/V.
Claim 11
Dependent Claim
26 words
The composition of claim 1 wherein the lubricant is neutral, has a low molecular weight, and is present in the suspension at 10% to 40% W/V.
Claim 12
Dependent Claim
22 words
The composition of claim 10 wherein the lubricant is maltose, dextrose, a triglyceride of a fatty acid, egg yold phospholipid, or glycerol.
Claim 13
Dependent Claim
11 words
The composition of claim 1 wherein the lubricant is hyaluronic acid.
Claim 14
Dependent Claim
14 words
The composition of claim 1 wherein the lubricant is soluble in the suspending medium.
Claim 15
Dependent Claim
24 words
The composition of claim 8 wherein the biomaterial is cross-linked collagen and the concentration of biomaterial in the suspension is 3% to 6% W/V.
Claim 16
Dependent Claim
24 words
The composition of claim 9 wherein the biomaterial is cross-linked collagen and the concentration of biomaterial in the suspension is 3% to 6% W/V.
Claim 17
Dependent Claim
24 words
The composition of claim 11 wherein the biomaterial is cross-linked collagen and the concentration of biomaterial in the suspension is 3% to 6% W/V.
Claim 18
Dependent Claim
24 words
The composition of claim 12 wherein the biomaterial is cross-linked collagen and the concentration of biomaterial in the suspension is 3% to 6% W/V.
Claim 19
Independent Claim
76 words
A method of improving the intrudability of a particulate biomaterial into soft tissue comprising incorporating a sufficient amount of a biocompatible fluid lubricant in the suspension to enhance the intrudability of the suspension into the tissue, wherein said particles of biomaterial are fibrils or beads comprising natural or synthetic polymers, and wherein said fluid lubricant comprises a non-fibrillar high molecular weight charged polymer, a high molecular weight neutral polymer, or a low molecular weight neutral molecule.
Claim 20
Independent Claim
76 words
A method of improving the intrudability of a particulate biomaterial into soft tissue comprising incorporating a sufficient amount of a biocompatible fluid lubricant in the suspension to enhance the intrudability of the suspension into the tissue, wherein said particles of biomaterial are fibrils or beads comprising natural or synthetic polymers, and wherein said fluid lubricant comprises a non-fibrillar high molecular weight charged polymer, a high molecular weight neutral polymer, or a low molecular weight neutral molecule.
Claim 21
Dependent Claim
20 words
The method of claim 18 wherein the concentration of said lubricant in the suspension is about 0.01% to 40% W/V.
Claim 22
Dependent Claim
12 words
The method of claim 18 wherein the lubricant is a charged polymer.
Claim 23
Dependent Claim
16 words
The method of claim 20 wherein the charged polymeric methylated collagen, succinylated collagen, or dextran sulfate.
Claim 24
Dependent Claim
35 words
The method of claim 18 wherein the lubricant is an uncharged polymer selected from the group consisting of dextran, heparin, and glycogen and the concentration of lubricant in the suspension is 10% to 40% W/V.
Claim 25
Dependent Claim
26 words
The method of claim 18 wherein the lubricant is neutral, has a low molecular weight and is present in the suspension at 10% to 40% W/V.
Claim 26
Dependent Claim
22 words
The method of claim 23 wherein the lubricant is maltose, dextrose, a triglyceride of a fatty acid, egg yolk phospholipid, or glycerol.
Claim 27
Dependent Claim
11 words
The method of claim 18 wherein the lubricant is hyaluronic acid.
Claim 28
Dependent Claim
24 words
A method for augmenting soft tissue in a living mammal comprising injecting the composition of claim 1 into the mammal at the augmentation site.
Claim 29
Dependent Claim
24 words
A method for augmenting soft tissue in a living mammal comprising injecting the composition of claim 8 into the mammal at the augmentation site.
Claim 30
Dependent Claim
24 words
A method for augmenting soft tissue in a living mammal comprising injecting the composition of claim 9 into the mammal at the augmentation site.
Claim 31
Dependent Claim
24 words
A method for augmenting soft tissue in a living mammal comprising injecting the composition of claim 11 into the mammal at the augmentation site.
Claim 32
Dependent Claim
24 words
A method for augmenting soft tissue in a living mammal comprising injecting the composition of claim 12 into the mammal at the augmentation site.
Claim 33
Dependent Claim
29 words
The composition of claim 1 wherein said biomaterial is selected from fibrillar crosslinked collagen, gelatin beads, polytetrafluoroethylene beads, silicone rubber beads, hydrogel beads, silicon carbide beads, and glass beads.
Claim 34
Dependent Claim
36 words
The composition of claim 1 wherein said fluid lubricant is selected from hyaluronic acid, dextran sulfate, dextran, succinylated non-crosslinked collagen, methylated non-cross-linked collagen, glycogen, glycerol, dextrose, maltose, triglycerides of fatty acids, egg yolk phospholipids, and heparin.
Claim 35
Dependent Claim
29 words
The method of claim 18 wherein said biomaterial is selected from fibrillar cross-linked collagen, gelatin beads, polytetrafluoroethylene beads, silicone rubber beads, hydrogel beads, silicon carbide beads, and glass beads.
Claim 36
Dependent Claim
36 words
The method of claim 18 wherein said fluid lubricant is selected from hyaluronic acid, dextran sulfate, dextran, succinylated non-cross-linked collagen, methylated non-cross-linked collagen, glycogen, glycerol, dextrose, maltose, triglycerides of fatty acids, egg yolk phospholipids, and heparin.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-02-07 | 1992-08-08 | 1993-02-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-02-07 | 1996-08-08 | 1997-02-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-02-07 | 2000-08-08 | 2001-02-07 | $7700.00 | Window Closed / Lapsed |