US5037429A
Expired / Lapsed
US
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Method for improving the storage stability of a polymeric braided suture susceptible to hydrolytic degradation and resulting article
Assignee: United States Surgical Corp
•
Filing: 1990-05-22
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Granted: 1991-08-06
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Expires: 2010-05-22
Abstract
Abstract The storage stability of a polymeric article susceptible to hydrolytic degradation, e.g., an absorbable suture manufactured from a polymer of glycolic acid, glycolide, lactic acid, lactide or combination thereof, is improved by applying a storage stabilizing amount of at least one water soluble hygroscopic polyhydroxy compound and/or ester thereof, e.g., glycerol, monoacetin, diacetin, and the like, to the article as storage stabilizing agent, said agent being retained by the article prior to sealing of the enclosure in which the suture is packaged.
Inventors
- 👤 Matthew E. Hermes
- 👤 Donald S. Kaplan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:14
CPC Classifications
A; A61; A61B; A61B17/00; A61B17/04; A61B17/06; A61B17/06166; A61B17/06114; A61L; A61L17/00; A61L17/14
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
39 words
A method for improving the storage stability of a bioabsorbable polymeric braided surgical suture fabricated from a polymer susceptible to hydrolysis which comprises applying a storage stabilizing amount of glycerol to a braided surgical suture formed from said polymer.
Claim 2
Independent Claim
39 words
A method for improving the storage stability of a bioabsorbable polymeric braided surgical suture fabricated from a polymer susceptible to hydrolysis which comprises applying a storage stabilizing amount of glycerol to a braided surgical suture formed from said polymer.
Claim 3
Dependent Claim
34 words
The method of claim 1 wherein said bioabsorbable polymeric braided surgical suture is fabricated in whole or in part from a polymer or copolymer of glycolic acid, glycolide, lactic acid, lactide or combination thereof.
Claim 4
Dependent Claim
17 words
The method of claim 1 wherein said glycerol is dissolved in at least one organic solvent therefor.
Claim 5
Dependent Claim
13 words
The method of claim 3 wherein the organic solvent is a lower alcohol.
Claim 6
Dependent Claim
24 words
The method of claim 1 wherein application of said glycerol is carried out by submerging said bioabsorbable polymeric braided surgical suture in said glycerol.
Claim 7
Dependent Claim
27 words
The method of claim 1 wherein application of said glycerol is carried out by coating, spraying or wiping said bioabsorbable polymeric braided surgical suture with said glycerol.
Claim 8
Dependent Claim
23 words
The method of claim 1 wherein said bioabsorbable polymeric braided surgical suture possesses a moisture content of greater than about 0.5 weight percent.
Claim 9
Dependent Claim
36 words
The method of claim 1 wherein said bioabsorbable polymeric braided surgical suture possesses a moisture content of up to about 1.5 weight percent at the time it is sealed within a substantially moisture impermeable enclosure therefor.
Claim 10
Dependent Claim
37 words
The method of claim 1 wherein said bioabsorbable polymeric braided surgical suture retains from about 2 to about 25 weight percent of said glycerol at the time it is sealed within a substantially moisture impermeable enclosure therefor.
Claim 11
Dependent Claim
21 words
The method of claim 1 wherein said glycerol contains dissolved therein an effective amount of at least one medico-surgically useful substance.
Claim 12
Dependent Claim
14 words
The method of claim 10 wherein said medico-surgically useful substance is tissue growth factor.
Claim 13
Independent Claim
51 words
A method for delivering a medico-surgically useful substance to a wound or surgical site which comprises applying to a bioabsorbable polymeric braided surgical suture fabricated from a polymer susceptible to hydrolysis intended to be contacted with said site, a composition comprising an effective amount of medico-surgically useful substance dissolved in glycerol.
Claim 14
Independent Claim
51 words
A method for delivering a medico-surgically useful substance to a wound or surgical site which comprises applying to a bioabsorbable polymeric braided surgical suture fabricated from a polymer susceptible to hydrolysis intended to be contacted with said site, a composition comprising an effective amount of medico-surgically useful substance dissolved in glycerol.
Claim 15
Dependent Claim
15 words
The method of claim 12 wherein the medico-surgically useful substance is a tissue growth factor.
Claim 16
Dependent Claim
32 words
A bioabsorbable polymeric braided surgical suture fabricated from a polymer which is susceptible to hydrolysis possessing a storage stabilizing amount of glycerol applied to the braided surgical suture formed from said polymer.
Claim 17
Dependent Claim
32 words
A bioabsorbable polymeric braided surgical suture fabricated from a polymer which is susceptible to hydrolysis possessing a storage stabilizing amount of glycerol applied to the braided surgical suture formed from said polymer.
Claim 18
Dependent Claim
30 words
The bioabsorbable polymeric braided surgical suture of claim 14 fabricated in whole or in part from a polymer or copolymer of glycolic acid, glycolide, lactic acid, lactide or combination thereof.
Claim 19
Dependent Claim
20 words
The bioabsorbable polymeric braided surgical suture of claim 14 possessing a moisture content of greater than about 0.05 weight percent.
Claim 20
Dependent Claim
21 words
The bioabsorbable braided surgical suture of claim 14 possessing a moisture content of from about 0.3 to about 1.0 weight percent.
Claim 21
Dependent Claim
21 words
The bioabsorbable polymeric braided surgical suture of claim 14 possessing from about 2 to about 25 weight percent of said glycerol.
Claim 22
Dependent Claim
25 words
The bioabsorbable polymeric braided surgical suture of claim 14 wherein said glycerol contains an effective amount of at least one medico-surgically useful substance dissolved therein.
Claim 23
Dependent Claim
18 words
The bioabsorbable polymeric braided surgical suture of claim 19 wherein said medico-surgically useful substance is tissue growth factor.
Claim 24
Independent Claim
63 words
A method of improving the storage stability of a bioabsorbable polymeric braided surgical suture fabricated in whole in or part from a polymer or copolymer susceptible to hydrolysis, said polymer or copolymer comprised of glycolic acid, glycolide, lactic acid, lactide or combinations thereof, which comprises applying a storage stabilizing amount of glycerol to a braided surgical suture formed from said polymer or copolymer.
Claim 25
Independent Claim
63 words
A method of improving the storage stability of a bioabsorbable polymeric braided surgical suture fabricated in whole in or part from a polymer or copolymer susceptible to hydrolysis, said polymer or copolymer comprised of glycolic acid, glycolide, lactic acid, lactide or combinations thereof, which comprises applying a storage stabilizing amount of glycerol to a braided surgical suture formed from said polymer or copolymer.
Claim 26
Dependent Claim
54 words
A bioabsorbable polymeric braided surgical suture fabricated in whole or in part from a polymer or copolymer susceptible to hydrolysis, said polymer or copolymer comprised of glycolic acid, glycolide, lactic acid, lactide or combinations thereof possessing a storage stabilizing amount of glycerol applied to the braided surgical suture formed from said polymer or copolymer.
Claim 27
Dependent Claim
54 words
A bioabsorbable polymeric braided surgical suture fabricated in whole or in part from a polymer or copolymer susceptible to hydrolysis, said polymer or copolymer comprised of glycolic acid, glycolide, lactic acid, lactide or combinations thereof possessing a storage stabilizing amount of glycerol applied to the braided surgical suture formed from said polymer or copolymer.
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1994-08-05 | 1995-02-04 | 1995-08-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-08-05 | 1999-02-04 | 1999-08-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-08-05 | 2003-02-04 | 2003-08-06 | $7700.00 | Window Closed / Lapsed |