Patent FR1028415A successfully refreshed from Google Patents.
US3955012A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method for manufacturing medical articles composed of silicone rubber coated with collagen
Assignee: Research Institute for Production Development
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Filing: 1973-11-16
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Granted: 1976-05-04
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Expires: 1993-11-16
Abstract
Abstract Medical articles composed of silicone rubber coated with collagen to be used in living body, are manufactured by subjecting a surface of shaped articles composed of silicone rubber to a spark discharge, coating the thus treated surface with an acidic aqueous solution of collagen and then drying said surface to form collagen layer and irradiating the shaped article coated with collagen with high energy ionizing radiation under an atmosphere having such a humidity that the water content of the coated collagen becomes more than 20% by weight.
Inventors
- 👤 Seizo Okamura
- 👤 Tsunetoshi Hino
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 22:01
CPC Classifications
C; C08; C08J; C08J7/00; C08J7/12; A; A61; A61L; A61L27/00; A61L27/28; A61L27/34; A61L33/00; A61L33/0094; C08L; C08L89/00; Y; Y10; Y10S; Y10S128/00; Y10S128/08; Y10S128/21
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
155 words
A method of manufacturing medical articles composed of silicone rubber coated with collagen and to be used in a living body comprising subjecting a surface of shaped articles composed of silicone rubber in an oxygen-containing atmosphere to a spark discharge wherein the product of the spark length in centimeters and the discharge time per square centimeter is in the range of 9 to 12 cm.sec/cm 2 , coating the thus treated surface with an acidic aqueous solution of collagen, drying the collagen coated shaped article at a temperature lower than the denaturation temperature of collagen to form a collagen layer, and irradiating the shaped article coated with collagen layer with gamma ray or electron beam to a dosage of 1-5×10 6 r or the equivalent dosage of ultraviolet light under an atmosphere having a humidity such that the water content of the coated collagen becomes greater than 20% by weight, thus fixing the collagen layer.
Claim 2
Independent Claim
155 words
A method of manufacturing medical articles composed of silicone rubber coated with collagen and to be used in a living body comprising subjecting a surface of shaped articles composed of silicone rubber in an oxygen-containing atmosphere to a spark discharge wherein the product of the spark length in centimeters and the discharge time per square centimeter is in the range of 9 to 12 cm.sec/cm 2 , coating the thus treated surface with an acidic aqueous solution of collagen, drying the collagen coated shaped article at a temperature lower than the denaturation temperature of collagen to form a collagen layer, and irradiating the shaped article coated with collagen layer with gamma ray or electron beam to a dosage of 1-5×10 6 r or the equivalent dosage of ultraviolet light under an atmosphere having a humidity such that the water content of the coated collagen becomes greater than 20% by weight, thus fixing the collagen layer.
Claim 3
Dependent Claim
28 words
The method as claimed in claim 1, wherein said gamma rays, electron beam or ultraviolet ray is irradiated under an atmosphere having a humidity of more than 75%.
Claim 4
Dependent Claim
20 words
The method as claimed in claim 1, wherein said gamma rays, electron beam or ultraviolet ray is irradiated in water.
Claim 5
Dependent Claim
20 words
The method as claimed in claim 1, wherein said shaped article is a film, pipe, tube, fiber, sponge or container.
Claim 6
Independent Claim
169 words
A method of manufacturing medical articles composed of silicone rubber coated with collagen to be used in a living body comprising subjecting a surface of a shaped article of film, pipe, tube, fiber or container composed of silicone rubber in an oxygen-containing atmosphere to a spark discharge of 9 to 12 cm.sec/cm 2 as determined from the spark length in centimeters and the discharge time, per square centimeter, coating the thus treated surface with an acidic aqueous solution of collagen, drying the collagen coated shaped article at a temperature lower than the denaturation temperature of collagen to form a collagen layer, neutralizing the acid in said collagen layer, washing the resulting salt with water, and irradiating the shaped article coated with collagen layer with gamma rays or electron beam in a dose of 1-5×10 6 r or the equivalent dosage of ultraviolet light under an atmosphere having a humidity such that the water content of the coated collagen becomes greater than 20% by weight, thus fixing the collagen layer.
Claim 7
Independent Claim
169 words
A method of manufacturing medical articles composed of silicone rubber coated with collagen to be used in a living body comprising subjecting a surface of a shaped article of film, pipe, tube, fiber or container composed of silicone rubber in an oxygen-containing atmosphere to a spark discharge of 9 to 12 cm.sec/cm 2 as determined from the spark length in centimeters and the discharge time, per square centimeter, coating the thus treated surface with an acidic aqueous solution of collagen, drying the collagen coated shaped article at a temperature lower than the denaturation temperature of collagen to form a collagen layer, neutralizing the acid in said collagen layer, washing the resulting salt with water, and irradiating the shaped article coated with collagen layer with gamma rays or electron beam in a dose of 1-5×10 6 r or the equivalent dosage of ultraviolet light under an atmosphere having a humidity such that the water content of the coated collagen becomes greater than 20% by weight, thus fixing the collagen layer.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-05-04 | 1979-11-03 | 1980-05-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-05-04 | 1983-11-03 | 1984-05-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-05-04 | 1987-11-03 | 1988-05-04 | $7700.00 | Window Closed / Lapsed |