US4526909A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Polymethylmethacrylate delivery system for bone morphogenetic protein
Assignee: University of California
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Filing: 1984-01-09
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Granted: 1985-07-02
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Expires: 2004-01-09
Abstract
Abstract A delivery system for delivering bone morphogenetic protein to induce formation of new bone in viable tissue. The delivery composition comprises substantially pure bone morphogenetic protein and polymethylmethacrylate and it is prepared by admixing the bone morphogenetic protein and polymethylmethacrylate. The composition is implanted in viable tissue where the bone morphogenetic protein is slowly released and induces formation of new bone.
Inventors
- 👤 Marshall R. Urist
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 00:35
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/14; A61L27/26; A61L24/00; A61L24/001; A61L24/0015; A61L24/04; A61L24/043; A61L27/50; A61L27/54; A61L2300/00; A61L2300/40; A61L2300/404; A61L2300/406; Y; Y10; Y10S; Y10S530/00; Y10S530/827; Y10S530/84; Y10S623/00; Y10S623/915; Y10S623/919
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
13 words
A composition comprising substantially pure bone morphogenetic protein and a polymeric acrylic ester.
Claim 2
Dependent Claim
13 words
A composition comprising substantially pure bone morphogenetic protein and a polymeric acrylic ester.
Claim 3
Dependent Claim
25 words
A delivery composition for delivering bone morphogenetic protein to induce formation of new bone in viable tissue comprising substantially pure bone morphogenetic protein and polymethylmethacrylate.
Claim 4
Dependent Claim
25 words
A delivery composition for delivering bone morphogenetic protein to induce formation of new bone in viable tissue comprising substantially pure bone morphogenetic protein and polymethylmethacrylate.
Claim 5
Dependent Claim
45 words
The delivery composition for delivering bone morphogenetic protein to induce formation of new bone in viable tissue, comprising bone morphogenetic protein and polymethylmethacrylate wherein the weight ratio of bone morphogenetic protein to polymethylmethacrylate is at least 0.05 parts bone morphogenetic protein to 16 parts polymethylmethacrylate.
Claim 6
Dependent Claim
45 words
The delivery composition for delivering bone morphogenetic protein to induce formation of new bone in viable tissue, comprising bone morphogenetic protein and polymethylmethacrylate wherein the weight ratio of bone morphogenetic protein to polymethylmethacrylate is at least 0.05 parts bone morphogenetic protein to 16 parts polymethylmethacrylate.
Claim 7
Dependent Claim
26 words
The delivery composition of claim 3 wherein said weight ratio is in the range of up to 2.0 parts bone morphogenetic protein to 16 parts polymethylmethacrylate.
Claim 8
Dependent Claim
13 words
The delivery composition of claim 3 including in said composition a radioopacifying agent.
Claim 9
Dependent Claim
12 words
The delivery composition of claim 3 including in said composition an antibiotic.
Claim 10
Independent Claim
47 words
The method of preparing a delivery composition for deliverying bone morphogenetic protein to induce formation of new bone in viable tissue comprising the step of admixing bone morphogenetic protein and polymethylmethacrylate in a weight ratio of at least 0.05 parts bone morphogenetic protein to 16 parts polymethylmethacrylate.
Claim 11
Independent Claim
47 words
The method of preparing a delivery composition for deliverying bone morphogenetic protein to induce formation of new bone in viable tissue comprising the step of admixing bone morphogenetic protein and polymethylmethacrylate in a weight ratio of at least 0.05 parts bone morphogenetic protein to 16 parts polymethylmethacrylate.
Claim 12
Dependent Claim
20 words
The method of claim 7 including the step of admixing liquid methylmethacrylate monomer with the bone morphogenetic protein polymethylmethacrylate admixture.
Claim 13
Dependent Claim
24 words
The method of claim 8 wherein the ratio of polymethylmethacrylate to methylmethacrylate is about 2 to 1, weight in grams to volume in milliliters.
Claim 14
Independent Claim
41 words
The method of inducing formation of new bone in viable tissue comprising implanting in viable tissue a delivery composition comprising bone morphogenetic protein and polymethylmethacrylate wherein the weight ratio is at least 0.05 parts bone morphogenetic protein to 16 parts polymethylmethacrylate.
Claim 15
Independent Claim
41 words
The method of inducing formation of new bone in viable tissue comprising implanting in viable tissue a delivery composition comprising bone morphogenetic protein and polymethylmethacrylate wherein the weight ratio is at least 0.05 parts bone morphogenetic protein to 16 parts polymethylmethacrylate.
References Cited (Backward Citations)
US4294753A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-07-01 | 1988-12-31 | 1989-07-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-07-01 | 1992-12-31 | 1993-07-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-07-01 | 1996-12-31 | 1997-07-02 | $7700.00 | Window Closed / Lapsed |