US4007089A
Expired / Lapsed
US
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Method for binding biologically active compounds
Assignee: Whitby Research Inc
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Filing: 1975-04-30
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Granted: 1977-02-08
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Expires: 1995-04-30
Abstract
Abstract A method for binding biologically active compounds to carriers comprising reacting an asymmetric bifunctional linking compound having at least one phenyl azide moiety and at least one s-triazine moiety with a carrier in the presence of light to form a carrier bound to the linking compound through the phenyl azide moiety, and reacting said carrier bound to the linking compound with a biologically active compound under reaction conditions sufficient to bind the biologically active compound to the linking compound through the s-triazine moiety.
Inventors
- 👤 Nathan L. Smith, III
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:21
CPC Classifications
C; C12; C12N; C12N11/00; C12N11/02; C12N11/06; Y; Y10; Y10S; Y10S530/00; Y10S530/81; Y10S530/812; Y10S530/815; Y10S530/816
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
162 words
A method for binding biologically active compounds to carriers comprising reacting an asymmetric bifunctional linking compound having the structural formula ##STR5## wherein B is selected from the group consisting of NR, O, S, ##STR6## and CH 2 ; (M) n is a saturated or unsaturated hydrocarbon chain; X is selected from the group consisting of N, R, O and S; A is selected from the group consisting of SO 2 R, CN, NO 2 and H; Y is selected from the group consisting of N 3 , halogen and SH, R is H or a lower alkyl group, D is N 3 or halogen and n is 1-12, with a carrier in the presence of light to form a carrier bound to the linking compound through the phenyl azide moiety, and reacting said carrier bound to the linking compound with a biologically active compound under reaction conditions sufficient to bind the biologically active compound to the linking compound through the s-triazine moiety.
Claim 2
Independent Claim
162 words
A method for binding biologically active compounds to carriers comprising reacting an asymmetric bifunctional linking compound having the structural formula ##STR5## wherein B is selected from the group consisting of NR, O, S, ##STR6## and CH 2 ; (M) n is a saturated or unsaturated hydrocarbon chain; X is selected from the group consisting of N, R, O and S; A is selected from the group consisting of SO 2 R, CN, NO 2 and H; Y is selected from the group consisting of N 3 , halogen and SH, R is H or a lower alkyl group, D is N 3 or halogen and n is 1-12, with a carrier in the presence of light to form a carrier bound to the linking compound through the phenyl azide moiety, and reacting said carrier bound to the linking compound with a biologically active compound under reaction conditions sufficient to bind the biologically active compound to the linking compound through the s-triazine moiety.
Claim 3
Dependent Claim
27 words
The method of claim 1, wherein the biologically active compound is selected from the group consisting of proteins, amino acids, carbohydrates, lipoproteins, coenzymes, enzyme inhibitors and vitamins.
Claim 4
Dependent Claim
22 words
The method of claim 1 wherein the biologically active compound is selected from the group consisting of peptides, enzymes, antibodies and antigens.
Claim 5
Dependent Claim
26 words
The method of claim 1 wherein the carrier is selected from the group consisting of a synthetic organic polymer and an organic polymer of biological origin.
Claim 6
Dependent Claim
25 words
The method of claim 1 wherein the polymer is selected from the group consisting of polyethylene, polypropylene, polymethylpentene, ethylene-propylene copolymer, polystyrene, polycarbonate, and polyvinyl chloride.
Claim 7
Dependent Claim
22 words
The method of claim 1 wherein the polymer is selected from the group consisting of cellulose, starch, pectin, mucopolysaccharides, lipoprotein and protein.
Claim 8
Dependent Claim
22 words
The method of claim 6 wherein the biologically active compound is selected from the group consisting of peptides, enzymes, antibodies and antigens.
References Cited (Backward Citations)
US3824150A
Cited
US3843447A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-02-08 | 1980-08-09 | 1981-02-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-02-08 | 1984-08-09 | 1985-02-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-02-08 | 1988-08-09 | 1989-02-08 | $7700.00 | Window Closed / Lapsed |