Patent US6371904B1 successfully refreshed from Google Patents.
US5002883A
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Covalent attachment of antibodies and antigens to solid phases using extended length heterobifunctional coupling agents
Assignee: Abbott Laboratories
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Filing: 1988-10-11
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Granted: 1991-03-26
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Expires: 2008-10-11
Abstract
Abstract Novel methods for covalent attachment of antibodies, antigens, or other molecules to solid phases using extended length heterobifunctional crosslinking reagents are disclosed. The resulting derivatized solid phases can be used in diagnostic assays.
Inventors
- 👤 Christopher Bieniarz
- 👤 Christopher J. Welch
- 👤 Grady Barnes
- 👤 Carol A. Schlesinger
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:22
CPC Classifications
C; C12; C12N; C12N11/00; C12N11/02; C12N11/06; C07; C07D; C07D207/00; C07D207/46; C07K; C07K17/00; C07K17/02; C07K17/06
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
56 words
A conjugate of the formula ##STR14## wherein Q is a thiol bearing peptide, polypeptide or protein; B is an amine bearing solid phase material; X is an amino acid having from three to ten carbon atoms in a straight chain; n is from one to ten; and R is a cycloakyl or an aromatic carbocycle ring.
Claim 2
Dependent Claim
56 words
A conjugate of the formula ##STR14## wherein Q is a thiol bearing peptide, polypeptide or protein; B is an amine bearing solid phase material; X is an amino acid having from three to ten carbon atoms in a straight chain; n is from one to ten; and R is a cycloakyl or an aromatic carbocycle ring.
Claim 3
Dependent Claim
9 words
The conjugate of claim 1 wherein R is cyclohexylmethyl.
Claim 4
Dependent Claim
12 words
The conjugate of claim 1 wherein B is an amine bearing microparticle.
Claim 5
Dependent Claim
9 words
The conjugate of claim 1 wherein X includes aminocaproyl.
Claim 6
Dependent Claim
21 words
The conjugate of claim 1 wherein Q is selected from the group of a hepatitis antigen, an enzyme, or an antibody.
Claim 7
Dependent Claim
12 words
The conjugate of claim 5 wherein said enzyme is selected from beta-galactosidase.
Claim 8
Dependent Claim
15 words
The conjugate of claim 5 wherein said antibody is selected from an anti-CA 125 antibody.
Claim 9
Dependent Claim
16 words
The conjugate of claim 5 wherein said hepatitis protein is selected from hepatitis B core antigen.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-03-25 | 1994-09-24 | 1995-03-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-03-25 | 1998-09-24 | 1999-03-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-03-25 | 2002-09-24 | 2003-03-26 | $7700.00 | Window Closed / Lapsed |