US4273873A
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Preparation of antithrombogenic polymeric materials
Assignee: Unitika Ltd
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Filing: 1977-10-25
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Granted: 1981-06-16
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Expires: 1997-10-25
Abstract
Abstract Antithrombogenic polymeric materials are prepared by bonding a synthetic fibrinolytic compound or a combination of a synthetic fibrinolytic compound and a fibrinolytic enzyme to a polymeric material. Bonding is preferably by covalent or ionic bonding. The antithrombogenic polymeric materials are useful for preparing various types of medical articles that come into contact with blood.
Inventors
- 👤 Akio Sugitachi
- 👤 Kunihiko Takagi
- 👤 Yasunori Yabushita
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 22:01
CPC Classifications
A; A61; A61L; A61L33/00; A61L33/0005; A61L33/0047; A61L33/0011; A61L33/0023; A61L33/0041; C; C12; C12N; C12N11/00; C12N11/02; C12N11/08; C12N11/089; C12N11/096
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
150 words
A process for preparing an antithrombogenic polymeric material, which comprises treating a polymeric material selected from the group consisting of polyacrylic acid, polymaleic acid, polyglutamic acid, alginic acid, polyethyleneimine, polymethacryloyl chloride, a polymer of bisphenol A and epichlorohydrin, polyacrolein, polymaleic anhydride, a polyamide, poly(ethylene terephthalate), a polyurethane, a silicone rubber, polyethylene, polypropylene, polyvinyl chloride, polyvinyl alcohol, polyacrylonitrile, cellulose, cellulose acetate, poly(methylmethacrylate), a polyester elastomer, poly(vinylbenzyl trialkyl ammonium ion), poly(vinylbenzyl dialkyl sulfonium ion), poly(vinylbenzyl trialkyl phosphonium ion), poly(dialkyloctamethylene ammonium ion), poly(N,N-dialkyl-3,5-methylenepiperidinium ion), and poly(dialkylaminoethyl methacrylate), with a solution of a synthetic compound which contributes to dissolution of fibrin, said synthetic compound being selected from the group consisting of a 1,2-diphenylpyrazolidine derivative, an anthranilic acid derivative, a salicylic acid derivative, a cinnamic acid derivative, a β-aryl substituted aliphatic acid, and a carboxylic acid containing a heterocyclic ring thereby to cause the synthetic compound to bond covalently or ionically to the polymeric material.
Claim 2
Dependent Claim
150 words
A process for preparing an antithrombogenic polymeric material, which comprises treating a polymeric material selected from the group consisting of polyacrylic acid, polymaleic acid, polyglutamic acid, alginic acid, polyethyleneimine, polymethacryloyl chloride, a polymer of bisphenol A and epichlorohydrin, polyacrolein, polymaleic anhydride, a polyamide, poly(ethylene terephthalate), a polyurethane, a silicone rubber, polyethylene, polypropylene, polyvinyl chloride, polyvinyl alcohol, polyacrylonitrile, cellulose, cellulose acetate, poly(methylmethacrylate), a polyester elastomer, poly(vinylbenzyl trialkyl ammonium ion), poly(vinylbenzyl dialkyl sulfonium ion), poly(vinylbenzyl trialkyl phosphonium ion), poly(dialkyloctamethylene ammonium ion), poly(N,N-dialkyl-3,5-methylenepiperidinium ion), and poly(dialkylaminoethyl methacrylate), with a solution of a synthetic compound which contributes to dissolution of fibrin, said synthetic compound being selected from the group consisting of a 1,2-diphenylpyrazolidine derivative, an anthranilic acid derivative, a salicylic acid derivative, a cinnamic acid derivative, a β-aryl substituted aliphatic acid, and a carboxylic acid containing a heterocyclic ring thereby to cause the synthetic compound to bond covalently or ionically to the polymeric material.
Claim 3
Dependent Claim
134 words
A process for preparing an antithrombogenic polymeric material, which comprises treating a polymeric material having a reactive functional group capable of forming a covalent bond, said reactive functional group being selected from the group consisting of a carboxy group, an amino group, a chloroformyl group, a diazonium group, an azido group, an epoxy group, a formyl group, a bromoacetyl group, an isocyanato group, a carboxylic acid anhydride group, and an imidocarbonato group, with a solution of a synthetic compound which contributes to dissolution of fibrin said synthetic compound being selected from the group consisting of a 1,2-diphenylpyrazolidine derivative, an anthranilic acid derivative, a salicylic acid derivative, a cinnamic acid derivative, a β-aryl substituted aliphatic acid, and a carboxylic acid containing a heterocyclic ring thereby to bond the synthetic compound covalently to the polymeric material.
Claim 4
Dependent Claim
134 words
A process for preparing an antithrombogenic polymeric material, which comprises treating a polymeric material having a reactive functional group capable of forming a covalent bond, said reactive functional group being selected from the group consisting of a carboxy group, an amino group, a chloroformyl group, a diazonium group, an azido group, an epoxy group, a formyl group, a bromoacetyl group, an isocyanato group, a carboxylic acid anhydride group, and an imidocarbonato group, with a solution of a synthetic compound which contributes to dissolution of fibrin said synthetic compound being selected from the group consisting of a 1,2-diphenylpyrazolidine derivative, an anthranilic acid derivative, a salicylic acid derivative, a cinnamic acid derivative, a β-aryl substituted aliphatic acid, and a carboxylic acid containing a heterocyclic ring thereby to bond the synthetic compound covalently to the polymeric material.
Claim 5
Dependent Claim
43 words
The process of claim 2, wherein the polymeric material having a reactive functional group capable of forming a covalent bond is polyacrylic acid, polymaleic acid, polyglutamic acid, alginic acid, polyethyleneimine, polymethacryloyl chloride, a polymer of bisphenol A and epichlorohydrin, polyacrolein, or polymaleic anhydride.
Claim 6
Dependent Claim
123 words
A process for preparing an antithrombogenic polymeric material, which comprises introducing a reactive functional group capable of forming a covalent bond into a polymeric material selected from the group consisting of a polyamide, poly(ethylene terephthalate), a polyurethane, a silicone rubber, polyethylene, polypropylene, polyvinyl chloride, polyvinyl alcohol, polyacrylonitrile, cellulose, cellulose acetate, poly(methylmethacrylate), and a polyester elastomer, and then treating the polymeric material with a solution of a synthetic compound which contributes to dissolution of fibrin said synthetic compound being selected from the group consisting of a 1,2-diphenylpyrazolidine derivative, an anthranilic acid derivative, a salicylic acid derivative, a cinnamic acid derivative a β-aryl substituted aliphatic acid, and a carboxylic acid containing a heterocyclic ring thereby to bond the synthetic compound covalently to the polymeric material.
Claim 7
Dependent Claim
123 words
A process for preparing an antithrombogenic polymeric material, which comprises introducing a reactive functional group capable of forming a covalent bond into a polymeric material selected from the group consisting of a polyamide, poly(ethylene terephthalate), a polyurethane, a silicone rubber, polyethylene, polypropylene, polyvinyl chloride, polyvinyl alcohol, polyacrylonitrile, cellulose, cellulose acetate, poly(methylmethacrylate), and a polyester elastomer, and then treating the polymeric material with a solution of a synthetic compound which contributes to dissolution of fibrin said synthetic compound being selected from the group consisting of a 1,2-diphenylpyrazolidine derivative, an anthranilic acid derivative, a salicylic acid derivative, a cinnamic acid derivative a β-aryl substituted aliphatic acid, and a carboxylic acid containing a heterocyclic ring thereby to bond the synthetic compound covalently to the polymeric material.
Claim 8
Dependent Claim
53 words
The process of claim 4, wherein the reactive functional group capable of forming a covalent bond is a carboxy group, an amino group, a chloroformyl group, a diazonium group, an azido group, an epoxy group, a formyl group, a bromoacetyl group, an isocyanato group, a carboxylic acid anhydride group, or an imidocarbonato group.
Claim 9
Dependent Claim
139 words
A process for preparing an antithrombogenic polymeric material, which comprises treating a polymeric material having an anion exchange group selected from the group consisting of a primary amino group, a secondary amino group, a tertiary amino group, a quaternary ammonium group, a tertiary sulfonium group and a quaternary phosphonium group present at the terminals of, and/or on the side chains of, and/or on the main chains of the polymeric material with a solution of a synthetic compound which contributes to dissolution of fibrin and is capable of forming an anion, said synthetic compound being selected from the group consisting of a 1,2-diphenylpyrazolidine derivative, an anthranilic acid derivative, a salicyclic acid derivative, a cinnamic acid derivative, a β-aryl substituted aliphatic acid, and a carboxylic acid containing a heterocyclic ring thereby to bond the synthetic compound ionically to the polymeric material.
Claim 10
Dependent Claim
139 words
A process for preparing an antithrombogenic polymeric material, which comprises treating a polymeric material having an anion exchange group selected from the group consisting of a primary amino group, a secondary amino group, a tertiary amino group, a quaternary ammonium group, a tertiary sulfonium group and a quaternary phosphonium group present at the terminals of, and/or on the side chains of, and/or on the main chains of the polymeric material with a solution of a synthetic compound which contributes to dissolution of fibrin and is capable of forming an anion, said synthetic compound being selected from the group consisting of a 1,2-diphenylpyrazolidine derivative, an anthranilic acid derivative, a salicyclic acid derivative, a cinnamic acid derivative, a β-aryl substituted aliphatic acid, and a carboxylic acid containing a heterocyclic ring thereby to bond the synthetic compound ionically to the polymeric material.
Claim 11
Dependent Claim
36 words
The process of claim 6, wherein the polymeric material having an anion exchange group is polyethyleneimine, poly(vinylbenzyl trialkyl ammonium ion), poly(vinylbenzyl dialkyl sulfonium ion), poly(vinylbenzyl trialkyl phosphonium ion), poly(dialkyloctamethylene ammonium ion), poly(N,N-dialkyl-3,5-methylenepiperidinium ion), or poly(dialkylaminoethyl methacrylate).
Claim 12
Dependent Claim
132 words
A process for preparing an antithrombogenic polymeric material, which comprises introducing a functional group containing an anion exchange group by chemical reaction into a polymeric material selected from the group consisting of a polyamide, poly(ethylene terephthalate), a polyurethane, a silicone rubber, polyethylene, polypropylene, polyvinyl chloride, polyvinyl alcohol, polyacrylonitrile, cellulose, cellulose acetate, poly(methyl methacrylate), and a polyester elastomer, and then treating the polymeric material with a solution of a synthetic compound which contributes to dissolution of fibrin and is capable of forming an anion, said synthetic compound being selected from the group consisting of a 1,2-diphenylpyrazolidine derivative, an anthranilic acid derivative, a salicylic acid derivative, a cinnamic acid derivative, a β-aryl substituted aliphatic acid, and a carboxylic acid containing a heterocyclic ring thereby to bond the synthetic compound ionically to the polymeric material.
Claim 13
Dependent Claim
132 words
A process for preparing an antithrombogenic polymeric material, which comprises introducing a functional group containing an anion exchange group by chemical reaction into a polymeric material selected from the group consisting of a polyamide, poly(ethylene terephthalate), a polyurethane, a silicone rubber, polyethylene, polypropylene, polyvinyl chloride, polyvinyl alcohol, polyacrylonitrile, cellulose, cellulose acetate, poly(methyl methacrylate), and a polyester elastomer, and then treating the polymeric material with a solution of a synthetic compound which contributes to dissolution of fibrin and is capable of forming an anion, said synthetic compound being selected from the group consisting of a 1,2-diphenylpyrazolidine derivative, an anthranilic acid derivative, a salicylic acid derivative, a cinnamic acid derivative, a β-aryl substituted aliphatic acid, and a carboxylic acid containing a heterocyclic ring thereby to bond the synthetic compound ionically to the polymeric material.
Claim 14
Dependent Claim
36 words
The process of claim 8, wherein the anion exchange group is a primary amino group, a secondary amino group, a tertiary amino group, a quaternary ammonium group, a tertiary sulfonium group or a quaternary phosphnium group.
Claim 15
Dependent Claim
94 words
A process for preparing an antithrombogenic polymeric material, which comprises treating a polymeric material with a solution of a synthetic compound which contributes to dissolution of fibrin, said synthetic compound being selected from the group consisting of a 1,2-diphenylpyrazolidine derivative, an anthranilic acid derivative, a salicylic acid derivative, a cinnamic acid derivative, a β-aryl substituted aliphatic acid, and a carboxylic acid containing a heterocyclic ring, and with a solution of a fibrinolytic enzyme, thereby to cause a covalent bonding or ionic bonding of said synthetic compound and of the enzyme to the polymeric material.
Claim 16
Dependent Claim
94 words
A process for preparing an antithrombogenic polymeric material, which comprises treating a polymeric material with a solution of a synthetic compound which contributes to dissolution of fibrin, said synthetic compound being selected from the group consisting of a 1,2-diphenylpyrazolidine derivative, an anthranilic acid derivative, a salicylic acid derivative, a cinnamic acid derivative, a β-aryl substituted aliphatic acid, and a carboxylic acid containing a heterocyclic ring, and with a solution of a fibrinolytic enzyme, thereby to cause a covalent bonding or ionic bonding of said synthetic compound and of the enzyme to the polymeric material.
Claim 17
Dependent Claim
10 words
The process of claim 10, wherein the enzyme is urokinase.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-06-15 | 1984-12-15 | 1985-06-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-06-15 | 1988-12-15 | 1989-06-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-06-15 | 1992-12-15 | 1993-06-16 | $7700.00 | Window Closed / Lapsed |