US5904718A
Expired / Lapsed
US
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Delayed drug delivery system
Assignee: Robert Bosch GmbH
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Filing: 1997-06-09
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Granted: 1999-05-18
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Expires: 2017-06-09
Abstract
Abstract A process and product comprising collagen and demineralized bone particles. The product may contain a maximum of 20% by weight inorganic materials. The product may densified by compression. Additional osteogenic factors, mitogens, drugs or antibiotics may be incorporated therein. Inorganic materials may be bound to the organic matrix via precoating with a calcium or hydroxyapatite binding protein, peptide or amino acid. The materials also display long lasting drug release characteristics.
Inventors
- 👤 Steven R. Jefferies
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 02:26
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3683; A61F; A61F2/00; A61F2/02; A61F2/28; A61L27/14; A61L27/22; A61L27/227; A61L27/24; A61L27/3604; A61L27/3608; A61L27/40; A61L27/44; A61L27/46; A61L27/50; A61L27/54; A61F2002/2817; A61F2/30; A61F2002/30001; A61F2002/30667; A61F2002/30677; A61F2250/00; A61F2250/0058; A61F2250/0067; A61F2310/00; A61F2310/00005; A61F2310/00365; A61L2300/00; A61L2300/40; A61L2300/404; A61L2300/406; A61L2300/412; A61L2300/414; A61L2300/43; A61L2300/60; A61L2300/602; A61L2430/00; A61L2430/02
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
98 words
A method of making a biocompatible, delivery system, comprising: a) dispersing a bioactive protein, peptide or drug within a plurality of protein particles selected from the group consisting of demineralized bone matrix, demineralized bone matrix extracted in chaotropic agents, reconstituted collagen or mixtures thereof; b) dispersing the particles of step (a) in an aqueous solution of about 0.002 to about 0.25 weight percent of a crosslinking agent and surface activating or partially crosslinking said particles; c) removing the particles of step (b) from the aqueous dispersion; and d) adding an organic matrix to said particles of step (c).
Claim 2
Independent Claim
98 words
A method of making a biocompatible, delivery system, comprising: a) dispersing a bioactive protein, peptide or drug within a plurality of protein particles selected from the group consisting of demineralized bone matrix, demineralized bone matrix extracted in chaotropic agents, reconstituted collagen or mixtures thereof; b) dispersing the particles of step (a) in an aqueous solution of about 0.002 to about 0.25 weight percent of a crosslinking agent and surface activating or partially crosslinking said particles; c) removing the particles of step (b) from the aqueous dispersion; and d) adding an organic matrix to said particles of step (c).
Claim 3
Independent Claim
98 words
A method of making a biocompatible, delivery system, comprising: a) dispersing a bioactive protein, peptide or drug within a plurality of protein particles selected from the group consisting of demineralized bone matrix, demineralized bone matrix extracted in chaotropic agents, reconstituted collagen or mixtures thereof; b) dispersing the particles of step (a) in an aqueous solution of about 0.002 to about 0.25 weight percent of a glutaraldehyde and surface activating or partially cross linking said particles; c) removing the particles of step (b) from the aqueous dispersion; and d) adding an organic matrix to said particles of step (c).
Claim 4
Independent Claim
98 words
A method of making a biocompatible, delivery system, comprising: a) dispersing a bioactive protein, peptide or drug within a plurality of protein particles selected from the group consisting of demineralized bone matrix, demineralized bone matrix extracted in chaotropic agents, reconstituted collagen or mixtures thereof; b) dispersing the particles of step (a) in an aqueous solution of about 0.002 to about 0.25 weight percent of a glutaraldehyde and surface activating or partially cross linking said particles; c) removing the particles of step (b) from the aqueous dispersion; and d) adding an organic matrix to said particles of step (c).
Claim 5
Dependent Claim
25 words
The method of claim 1 or claim 2 wherein the organic matrix is collagen, gelatin, blood proteins, blood serum, blood plasma, fibrin, or mixtures thereof.
Claim 6
Dependent Claim
14 words
The method of claim 1 or claim 2 wherein said drug is an antibiotic.
Claim 7
Dependent Claim
34 words
The method of claim 1 or claim 2 wherein the bioactive protein or peptide is bone morphogenic protein, insulin-like growth factor, nerve growth factor, human growth hormone, bovine growth hormone, or porcine growth hormone.
Claim 8
Dependent Claim
22 words
The method of claim 1 or claim 2 wherein said particles of step (b) are each about 65% to about 70% uncrosslinked.
Claim 9
Independent Claim
78 words
A method of making a biocompatible delivery system comprising: b) dispersing a bioactive protein, peptide or drug within a plurality of coated inorganic particles, said inorganic particles having a protein based surface layer bound thereto; b) dispersing the particles of step (a) in an aqueous solution of about 0.002 to about 0.25 weight percent of a glutaraldehyde and surface activating or partially cross linking said particles; and c) removing the particles of step (b) from the aqueous dispersion.
Claim 10
Independent Claim
78 words
A method of making a biocompatible delivery system comprising: b) dispersing a bioactive protein, peptide or drug within a plurality of coated inorganic particles, said inorganic particles having a protein based surface layer bound thereto; b) dispersing the particles of step (a) in an aqueous solution of about 0.002 to about 0.25 weight percent of a glutaraldehyde and surface activating or partially cross linking said particles; and c) removing the particles of step (b) from the aqueous dispersion.
Claim 11
Dependent Claim
20 words
The method of claim 7 wherein the glutaraldehyde is in the range of about 0.002 to about 0.09 weight percent.
Claim 12
Dependent Claim
24 words
The method of claim 7 further comprising the step of treating said particles of step (a) with carbodiimide and with an amine or diamine.
Claim 13
Dependent Claim
29 words
The method of claim 9, wherein the coated inorganic particles are selected from the group consisting of calcium hydroxide, calcium phosphate, hydroxyapatite, tricalcium phosphate, or a phosphate ceramic material.
Claim 14
Dependent Claim
42 words
The method of claim 9, wherein the coated inorganic particles are prepared by coating inorganic particles with collagen, gelatin, L-Y-carboxyglutamic acid, the sodium salt of poly-L-glutamic or the random copolymer of L-glutamic acid containing at least one lysine in its repeating structure.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2002-05-17 | 2002-11-16 | 2003-05-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2006-05-17 | 2006-11-16 | 2007-05-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2010-05-17 | 2010-11-16 | 2011-05-18 | $7700.00 | Window Closed / Lapsed |