US4563350A
Expired / Lapsed
US
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Inductive collagen based bone repair preparations
Assignee: Collagen Aesthetics Inc
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Filing: 1984-10-24
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Granted: 1986-01-07
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Expires: 2004-10-24
Abstract
Abstract A composition suitable for inductive bone implants is disclosed. The composition comprises a purified form of osteogenic factor in admixture with an carrier having a percentage of non-fibrillar collagen. The resulting implants are sufficiently hypo-immunogenic to be effective when implanted in xenogeneic hosts.
Inventors
- 👤 Ranga Nathan
- 👤 Saied Seyedin
- 👤 Karl Piez
- 👤 Hanne Bentz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 00:07
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/475; C07K14/51; A; A61; A61F; A61F2/00; A61F2/02; A61F2/28; A61K; A61K35/00; A61K35/12; A61K35/32; A61L; A61L27/00; A61L27/14; A61L27/22; A61L27/227; A61L27/36; A61P; A61P37/00; A61P37/02; A61P37/06; A61K38/00; A61L2430/00; A61L2430/02
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
61 words
A hypoimmunogenic composition suitable for implantation to effect bone repair in a vertebrate which comprises an osteoinductively effective amount of a protein osteoinductive factor (OF) derived from bone, which OF is sufficiently pure to be hypoimmunogenic in a xenogeneic host in admixture with a carrier which is hypoimmunogenic in a xenogeneic host containing at least 5% by weight of non-fibrillar collagen.
Claim 2
Dependent Claim
61 words
A hypoimmunogenic composition suitable for implantation to effect bone repair in a vertebrate which comprises an osteoinductively effective amount of a protein osteoinductive factor (OF) derived from bone, which OF is sufficiently pure to be hypoimmunogenic in a xenogeneic host in admixture with a carrier which is hypoimmunogenic in a xenogeneic host containing at least 5% by weight of non-fibrillar collagen.
Claim 3
Dependent Claim
19 words
The composition of claim 1 wherein the OF comprises between about 1 ppm and 1000 ppm of the implant.
Claim 4
Dependent Claim
17 words
The composition of claim 1 wherein the carrier contains at least 10% by weight of non-fibrillar collagen.
Claim 5
Dependent Claim
12 words
The composition of claim 1 wherein the non-fibrillar collagen is atelopeptide collagen.
Claim 6
Dependent Claim
15 words
The composition of claim 1 wherein the non-fibrillar collagen is provided as collagen in solution.
Claim 7
Dependent Claim
18 words
The composition of claim 1 wherein the carrier contains bone collagen powder in an amount not exceeding 95%.
Claim 8
Dependent Claim
16 words
The composition of claim 1 wherein the carrier contains hydroxyapatite in an amount not exceeding 95%.
Claim 9
Dependent Claim
24 words
The composition of claim 1 wherein the carrier contains a mixture of bone collagen powder and hydroxyapatite in a total amount not exceeding 95%.
Claim 10
Dependent Claim
36 words
The composition of claim 1 wherein the OF is prepared by a process which includes treating a chaotropic extract of bone with a molecular sieve to isolate a fraction of molecular weight of less than 30,000.
Claim 11
Dependent Claim
21 words
The composition of claim 9 wherein the OF is further purified by treating with DEAE cellulose and utilizing the unbound fraction.
Claim 12
Dependent Claim
24 words
The composition of claim 9 wherein the OF is further purified by absorbing said fraction to a cation exchange resin and recovering the factor.
Claim 13
Dependent Claim
13 words
The composition of claim 11 wherein the OF is further purified by HPLC.
Claim 14
Dependent Claim
14 words
The composition of claim 11 wherein the OF is further purified by gel electrophoresis.
Claim 15
Independent Claim
70 words
A method of effecting bone repair in vertebrates which comprises implanting into a bone defect a composition hypoimmunogenic in a xenogeneic host which comprises an osteoinductively effective amount of a protein osteoinductive factor (OF) derived from bone, which OF is sufficiently pure to be hypoimmunogenic in a xenogeneic host, in admixture with a carrier which is hypoimmunogenic in a xenogeneic host containing at least 5% by weight of non-fibrillar collagen.
Claim 16
Independent Claim
70 words
A method of effecting bone repair in vertebrates which comprises implanting into a bone defect a composition hypoimmunogenic in a xenogeneic host which comprises an osteoinductively effective amount of a protein osteoinductive factor (OF) derived from bone, which OF is sufficiently pure to be hypoimmunogenic in a xenogeneic host, in admixture with a carrier which is hypoimmunogenic in a xenogeneic host containing at least 5% by weight of non-fibrillar collagen.
References Cited (Backward Citations)
US4488911A
Cited
US4294753A
Cited
US4314380A
Cited
US4407787A
Cited
US4394370A
Cited
US4430760A
Cited
US4440750A
Cited
US4485097A
Cited
US4434094A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-01-06 | 1989-07-08 | 1990-01-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-01-06 | 1993-07-08 | 1994-01-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-01-06 | 1997-07-08 | 1998-01-07 | $7700.00 | Window Closed / Lapsed |