US4563489A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Biodegradable organic polymer delivery system for bone morphogenetic protein
Assignee: University of California
•
Filing: 1984-02-10
•
Granted: 1986-01-07
•
Expires: 2004-02-10
Abstract
Abstract Disclosed is a biodegradable polylactic acid polymer delivery system for delivery of bone morphogenic protein (BMP) to induce formation of new bone in viable tissue. The delivery composition is substantially pure BMP in combination with a biodegradable polylactic acid polymer and it is prepared by admixing the BMP with the biodegradable polymer. The composition is implanted in viable tissue where the BMP is slowly released and induces formation of new bone.
Inventors
- 👤 Marshall R. Urist
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:59
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/14; A61L27/22; A61L27/227; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2031; A61K9/204; A61L27/26; Y; Y10; Y10S; Y10S623/00; Y10S623/915
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
13 words
A composition comprising substantially pure BMP and physiologically acceptable, biodegradable polylactic acid polymer.
Claim 2
Dependent Claim
13 words
A composition comprising substantially pure BMP and physiologically acceptable, biodegradable polylactic acid polymer.
Claim 3
Dependent Claim
24 words
A composition comprising substantially pure BMP and a physiologically acceptable, biodegradable organic polymer selected from polylactic acid, polylactide, polyglycollic acid, polyglactin or polyglactic acid.
Claim 4
Dependent Claim
24 words
A composition comprising substantially pure BMP and a physiologically acceptable, biodegradable organic polymer selected from polylactic acid, polylactide, polyglycollic acid, polyglactin or polyglactic acid.
Claim 5
Dependent Claim
27 words
A delivery composition for delivering BMP to induce formation of new bone in viable tissue comprising substantially pure BMP and a physiologically acceptable, biodegradable polylactic acid polymer.
Claim 6
Dependent Claim
27 words
A delivery composition for delivering BMP to induce formation of new bone in viable tissue comprising substantially pure BMP and a physiologically acceptable, biodegradable polylactic acid polymer.
Claim 7
Dependent Claim
36 words
The delivery composition according to claim 3 to induce formation of new bone in viable tissue wherein the weight ratio of BMP to polymer is at least about 0.05 parts BMP to about 20 parts polymer.
Claim 8
Dependent Claim
22 words
The delivery composition according to claim 4 wherein the ratio is at least about 0.1 parts BMP to about 20 parts polymer.
Claim 9
Dependent Claim
24 words
The delivery composition of claim 5 wherein said weight ratio is in the range of up to 10 parts BMP to 20 parts polymer.
Claim 10
Dependent Claim
13 words
The delivery composition of claim 4 including in said composition a radioopacifying agent.
Claim 11
Dependent Claim
12 words
The delivery composition of claim 4 including in said composition an antibiotic.
Claim 12
Dependent Claim
37 words
A delivery composition for delivering BMP to induce formation of new bone in viable tissue comprising substantially pure BMP and a physiologically acceptable, biodegradable organic polymer selected from polylactic acid, polylactide, polyglycollic acid, polyglactin or polyglactic acid.
Claim 13
Dependent Claim
37 words
A delivery composition for delivering BMP to induce formation of new bone in viable tissue comprising substantially pure BMP and a physiologically acceptable, biodegradable organic polymer selected from polylactic acid, polylactide, polyglycollic acid, polyglactin or polyglactic acid.
Claim 14
Independent Claim
97 words
The method of preparing a delivery composition for delivering BMP to induce formation of new bone in viable tissue comprising the step of dissolving physiologically acceptable, biodegradable polylactic polymer in a solvent to form a solution, admixing the solution and BMP to form a dispersion, adding a second solvent to the dispersion which causes the precipitation of the polymer and forms a composite of said polymer and said BMP, and removing the solvents from said composite to form said composition, the weight ratio of BMP and polymer being at least 0.05 parts BMP to 20 parts polymer.
Claim 15
Independent Claim
97 words
The method of preparing a delivery composition for delivering BMP to induce formation of new bone in viable tissue comprising the step of dissolving physiologically acceptable, biodegradable polylactic polymer in a solvent to form a solution, admixing the solution and BMP to form a dispersion, adding a second solvent to the dispersion which causes the precipitation of the polymer and forms a composite of said polymer and said BMP, and removing the solvents from said composite to form said composition, the weight ratio of BMP and polymer being at least 0.05 parts BMP to 20 parts polymer.
Claim 16
Independent Claim
46 words
The method of inducing formation of new bone in viable tissue comprising implanting in said viable tissue a delivery composition comprising BMP and a physiologically acceptable, biodegradable polylactic acid polymer wherein the weight ratio is at least about 0.05 parts BMP to about 20 parts polymer.
Claim 17
Independent Claim
46 words
The method of inducing formation of new bone in viable tissue comprising implanting in said viable tissue a delivery composition comprising BMP and a physiologically acceptable, biodegradable polylactic acid polymer wherein the weight ratio is at least about 0.05 parts BMP to about 20 parts polymer.
Claim 18
Dependent Claim
22 words
A method according to claim 11 wherein the weight ratio is at least about 0.1 parts BMP to about 20 parts polymer.
Claim 19
Dependent Claim
22 words
A method according to claim 12 wherein the weight ratio is at least about 0.1 parts BMP to about 20 prts polymer.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-01-06 | 1989-07-08 | 1990-01-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-01-06 | 1993-07-08 | 1994-01-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-01-06 | 1997-07-08 | 1998-01-07 | $7700.00 | Window Closed / Lapsed |