Patent GB613270A successfully refreshed from Google Patents.
US4620327A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process of adapting soluble bone protein for use in stimulating osteoinduction
Assignee: Individual
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Filing: 1984-07-05
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Granted: 1986-11-04
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Expires: 2004-07-05
Abstract
Abstract A method for treating implants such as biodegradable masses, xenogenic bony implants, allografts and prosthetic devices with soluble bone protein to enhance or stimulate new cartilage and/or bone formation. Substrate immobilization or surface coating techniques retard diffusion of the soluble bone protein away from the implant site so that cartilage and bone growth is initiated.
Inventors
- 👤 Arnold I. Caplan
- 👤 Glenn T. Syftestad
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 07:02
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/50; A61L27/54; A61F; A61F2/00; A61F2/02; A61F2/28; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/18; A61K38/1875; A61L27/14; A61L27/22; A61L27/227; A61L27/28; A61L27/34; A61L2300/00; A61L2300/60; A61L2300/602; Y; Y10; Y10S; Y10S623/00; Y10S623/92; Y10S623/923
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
52 words
A method of adapting soluble bone protein for use in osteoinduction comprising combining soluble bone protein purified to a state effective to initiate chondrogenesis with a biocompatible, biodegradable mass capable of releasing the protein in a time dependent manner for retarding diffusion of said protein from a site of in vivo implantation.
Claim 2
Independent Claim
52 words
A method of adapting soluble bone protein for use in osteoinduction comprising combining soluble bone protein purified to a state effective to initiate chondrogenesis with a biocompatible, biodegradable mass capable of releasing the protein in a time dependent manner for retarding diffusion of said protein from a site of in vivo implantation.
Claim 3
Independent Claim
41 words
A method of adapting soluble bone protein for use in osteoinduction comprising combining soluble bone protein purified to a state effective to inititate chondrogenesis with a fibrin clot for retarding diffusion of said protein from a site of in vivo implantation.
Claim 4
Independent Claim
41 words
A method of adapting soluble bone protein for use in osteoinduction comprising combining soluble bone protein purified to a state effective to inititate chondrogenesis with a fibrin clot for retarding diffusion of said protein from a site of in vivo implantation.
Claim 5
Independent Claim
58 words
A method of adapting soluble bone protein for use in osteoinduction comprising the steps of soaking an allograft in an aqueous solution of a controlled release agent and soluble bone protein purified to a state effective to initiate chondrogenesis, and drying the allograft to form an adherent coating capable of releasing the protein in a time dependent manner.
Claim 6
Independent Claim
58 words
A method of adapting soluble bone protein for use in osteoinduction comprising the steps of soaking an allograft in an aqueous solution of a controlled release agent and soluble bone protein purified to a state effective to initiate chondrogenesis, and drying the allograft to form an adherent coating capable of releasing the protein in a time dependent manner.
Claim 7
Independent Claim
60 words
A method of adapting soluble bone protein for use in osteoinduction comprising the steps of soaking demineralized, defatted bone, extracted to remove biological or immunological properties, in an aqueous solution of bone protein purified to a state effective to initiate chondrogenesis, and cross-linking the treated bone so that it is capable of releasing the protein in a time dependent manner.
Claim 8
Independent Claim
60 words
A method of adapting soluble bone protein for use in osteoinduction comprising the steps of soaking demineralized, defatted bone, extracted to remove biological or immunological properties, in an aqueous solution of bone protein purified to a state effective to initiate chondrogenesis, and cross-linking the treated bone so that it is capable of releasing the protein in a time dependent manner.
Claim 9
Independent Claim
58 words
A method of adapting soluble bone protein for use in osteoinduction comprising the steps of soaking a prosthesis in a surface coating solution of a controlled release agent and bone protein purified to a state effective to initiate chondrogenesis and drying the prosthesis to form an adherent coating capable of releasing the protein in a time dependent manner.
Claim 10
Independent Claim
58 words
A method of adapting soluble bone protein for use in osteoinduction comprising the steps of soaking a prosthesis in a surface coating solution of a controlled release agent and bone protein purified to a state effective to initiate chondrogenesis and drying the prosthesis to form an adherent coating capable of releasing the protein in a time dependent manner.
Claim 11
Dependent Claim
24 words
The method of claim 3 wherein the controlled release agent is at least one member selected from the group consisting of gelatin and fibrin.
Claim 12
Dependent Claim
24 words
The method of claim 5 wherein the controlled release agent is at least one member selected from the group consisting of gelatin and fibrin.
Claim 13
Independent Claim
66 words
A method of adapting soluble bone protein for use in osteoinduction comprising combining soluble bone protein purified to a state effective to initiate chondrogenesis with bony implant means and a surface coating solution capable of being dried to form an adherent biodegradable coating capable of releasing the protein in a time dependent manner for retarding diffusion of said protein from a site of in vivo implantation.
Claim 14
Independent Claim
66 words
A method of adapting soluble bone protein for use in osteoinduction comprising combining soluble bone protein purified to a state effective to initiate chondrogenesis with bony implant means and a surface coating solution capable of being dried to form an adherent biodegradable coating capable of releasing the protein in a time dependent manner for retarding diffusion of said protein from a site of in vivo implantation.
Claim 15
Dependent Claim
27 words
The method of claim 8 wherein the surface coating solution is a solution of at least one member selected from the group consisting of gelatin and fibrin.
Claim 16
Independent Claim
64 words
A method of adapting a soluble bone protein for use in osteoinduction comprising combining soluble bone protein purified to a state effective to initiate chondrogenesis with bony implant means and thereafter cross linking said bony implant means so that it is capable of releasing the protein in a time dependent manner for retarding diffusion of said protein from a site of in vivo implantation.
Claim 17
Independent Claim
64 words
A method of adapting a soluble bone protein for use in osteoinduction comprising combining soluble bone protein purified to a state effective to initiate chondrogenesis with bony implant means and thereafter cross linking said bony implant means so that it is capable of releasing the protein in a time dependent manner for retarding diffusion of said protein from a site of in vivo implantation.
Claim 18
Independent Claim
69 words
A method of adapting soluble bone protein for use in osteoinduction comprising combining soluble bone protein purified to a state effective to initiate chondrogenesis with a prosthesis and a surface coating solution capable of being dried to form an adherent biodegradable coating so that it is capable of releasing the protein in a time dependent manner for retarding diffusion of said protein from a site of in vivo implantation.
Claim 19
Independent Claim
69 words
A method of adapting soluble bone protein for use in osteoinduction comprising combining soluble bone protein purified to a state effective to initiate chondrogenesis with a prosthesis and a surface coating solution capable of being dried to form an adherent biodegradable coating so that it is capable of releasing the protein in a time dependent manner for retarding diffusion of said protein from a site of in vivo implantation.
Claim 20
Dependent Claim
27 words
The method of claim 11 wherein said surface coating solution is a solution of at least one member selected from the group consisting of gelating and fibrin.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-11-03 | 1990-05-05 | 1990-11-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-11-03 | 1994-05-05 | 1994-11-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-11-03 | 1998-05-05 | 1998-11-04 | $7700.00 | Window Closed / Lapsed |