US5876452A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Biodegradable implant
Assignee: The University of Texas System
•
Filing: 1995-05-30
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Granted: 1999-03-02
•
Expires: 2015-05-30
Abstract
Abstract Biodegradable, porous, polymeric implant material provides substantially continuous release of bioactive agent during in vivo use. Bioactive agent is initially released in amounts that are less than degradation rate of polymer, thereby promoting migration of cells into material. Later larger amounts of bioactive agent are released, thereby promoting differentiation of cells. Method of making material includes steps of applying vacuum temperature and consession to form pores. Implant material may be adapted for one phase implant (e.g., for bone or cartilage) or for two phase layered implant (e.g., for cartilage layer on top of bone layer).
Inventors
- 👤 Kyriacos A. Athanasiou
- 👤 Barbara D. Boyan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:29
CPC Classifications
A; A61; A61L; A61L31/00; A61L31/14; A61L31/148; A61F; A61F2/00; A61F2/02; A61F2/28; A61F2/30; A61F2/30756; A61L31/146; A61F2/3094; A61F2/0077; A61F2002/0086; A61F2002/2817; A61F2002/2835; A61F2002/2839; A61F2002/30001; A61F2002/30003; A61F2002/30004; A61F2002/30011; A61F2002/30014; A61F2002/30032; A61F2002/3006; A61F2002/30062; A61F2002/30108; A61F2002/30199; A61F2002/30224; A61F2002/30667; A61F2002/30677; A61F2/30767; A61F2002/3093; A61F2002/30971; A61F2210/00; A61F2210/0004; A61F2230/00; A61F2230/0063; A61F2230/0069; A61F2240/00; A61F2240/001; A61F2250/00; A61F2250/0014; A61F2250/0018; A61F2250/0023; A61F2250/003
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
49 words
A porous bioerodible tissue implant device comprising a bioerodible synthetic polymeric material having a uniform non-fibrous composition characterized in that said material has a predetermined uniform porosity and is adapted to be implanted during use into cartilage, said polymeric material having the stiffness and compressibility properties of said cartilage.
Claim 2
Dependent Claim
49 words
A porous bioerodible tissue implant device comprising a bioerodible synthetic polymeric material having a uniform non-fibrous composition characterized in that said material has a predetermined uniform porosity and is adapted to be implanted during use into cartilage, said polymeric material having the stiffness and compressibility properties of said cartilage.
Claim 3
Dependent Claim
59 words
A molded, porous bioerodible tissue implant device comprising a bioerodible polymeric material, said device having a uniform, substantially solid, composition throughout the volume enclosed by the implant, characterized in that said material has a predetermined uniform porosity and is adapted to be implanted during use into bone, said polymeric material having the stiffness and compressibility properties of said bone.
Claim 4
Dependent Claim
59 words
A molded, porous bioerodible tissue implant device comprising a bioerodible polymeric material, said device having a uniform, substantially solid, composition throughout the volume enclosed by the implant, characterized in that said material has a predetermined uniform porosity and is adapted to be implanted during use into bone, said polymeric material having the stiffness and compressibility properties of said bone.
Claim 5
Dependent Claim
21 words
An implant device of claim 1 having access sites for receiving growth of tissue therein comprising passages extending into the material.
Claim 6
Dependent Claim
21 words
An implant device of claim 2 having access sites for receiving growth of tissue therein comprising passages extending into the material.
Claim 7
Dependent Claim
26 words
An implant device of claim 1 having a growth factor, bioactive agent to induce, promote, or support tissue ingrowth and repair incorporated into said polymeric material.
Claim 8
Dependent Claim
26 words
An implant device of claim 2 having a growth factor, bioactive agent to induce, promote, or support tissue ingrowth and repair incorporated into said polymeric material.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2002-03-01 | 2002-08-31 | 2003-03-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2006-03-01 | 2006-08-31 | 2007-03-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2010-03-01 | 2010-08-31 | 2011-03-02 | $7700.00 | Window Closed / Lapsed |