US4655777A
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US
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Method of producing biodegradable prosthesis and products therefrom
Assignee: Southern Research Institute
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Filing: 1983-12-19
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Granted: 1987-04-07
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Expires: 2003-12-19
Abstract
Abstract Method of producing biodegradable prostheses comprising a composite of resorbable fibers reinforcing a biodegradable polymer matrix and the use thereof in medical applications such as bone plates and other orthopedic devices. The fibers include ceramic powders, β-TCP and CaAl and a biodegradable glass, CMP.
Inventors
- 👤 Richard L. Dunn
- 👤 Robert A. Casper
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 20:59
CPC Classifications
C; C08; C08K; C08K7/00; C08K7/02; C08K7/04; C08K7/08; A; A61; A61L; A61L27/00; A61L27/40; A61L27/44; A61L27/46; A61L27/50; A61L27/58
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
72 words
A method of producing a totally biodegradable prosthesis or implant comprising the steps of (a) encasing an effective amount of fibers selected from the group consisting of calcium phosphate, and calcium aluminate in a matrix of a polymer selected from the group consisting of polyglycolide, poly(DL-lactide), poly(L-lactide), polycaprolactone, polydioxanone, polyesteramides, copolyoxalates, polycarbonate, poly(glutamic-co-leucine) and blends, copolymers and terpolymers thereof to form a composite; and (b) forming said composite to the desired shape.
Claim 2
Independent Claim
72 words
A method of producing a totally biodegradable prosthesis or implant comprising the steps of (a) encasing an effective amount of fibers selected from the group consisting of calcium phosphate, and calcium aluminate in a matrix of a polymer selected from the group consisting of polyglycolide, poly(DL-lactide), poly(L-lactide), polycaprolactone, polydioxanone, polyesteramides, copolyoxalates, polycarbonate, poly(glutamic-co-leucine) and blends, copolymers and terpolymers thereof to form a composite; and (b) forming said composite to the desired shape.
Claim 3
Dependent Claim
17 words
A method as defined in claim 1 wherein said calcium phosphate fibers are comprised of β-tricalcium phosphate.
Claim 4
Dependent Claim
17 words
A method as defined in claim 1 wherein said calcium phosphate fibers are comprised of calcium metaphosphate.
Claim 5
Dependent Claim
16 words
A method a defined in claim 1 wherein said effective amount ranges from 10-90% by volume.
Claim 6
Dependent Claim
16 words
A method as defined in claim 1 wherein said effective amount is preferably 30-80% by volume.
Claim 7
Dependent Claim
19 words
A method as defined in claim 1 wherein the aspect ratio of said fibers ranges from 10:1 to 1,000,000:1.
Claim 8
Dependent Claim
71 words
A biodegradable prosthesis or implant, comprising (a) a matrix formed from a polymer selected from the group consisting of polyglycolide, poly(DL-lactide), poly(L-lactide), polycaprolactone, polydioxanone, polyesteramides, copolyoxalates, polycarbonate, poly(glutamic-co-leucine) and blends, copolymers and terpolymers thereof; and (b) fibers selected from the group consisting of calcium phosphate and calcium aluminate incorporated within said matrix in an amount ranging from 10-90% by volume and said fibers having an aspect ratio of 10:1 to 1,000,000:1.
Claim 9
Dependent Claim
71 words
A biodegradable prosthesis or implant, comprising (a) a matrix formed from a polymer selected from the group consisting of polyglycolide, poly(DL-lactide), poly(L-lactide), polycaprolactone, polydioxanone, polyesteramides, copolyoxalates, polycarbonate, poly(glutamic-co-leucine) and blends, copolymers and terpolymers thereof; and (b) fibers selected from the group consisting of calcium phosphate and calcium aluminate incorporated within said matrix in an amount ranging from 10-90% by volume and said fibers having an aspect ratio of 10:1 to 1,000,000:1.
Claim 10
Dependent Claim
37 words
A biodegradable prosthesis or implant as defined in claim 7 wherein said matrix is a film of said polymer and said prosthesis or implant comprises a predetermined number of alternating layers of said film and said fibers.
Claim 11
Independent Claim
70 words
A method of repairing fractured bone segments in animals, comprising the step of surgically implanting adjacent said bone segments a prosthesis or implant formed of a composite of fibers selected from the group consisting of calcium phosphate and calcium aluminate, said fibers reinforcing a matrix formed from a polymer selected from the group consisting of polyglycolide, poly(DL-lactide), poly(L-lactide), polycaprolactone, polydioxanone, polyesteramides, copolyoxalates, polycarbonate, poly(glutamic-co-leucine) and blends, copolymers and terpolymers thereof.
Claim 12
Independent Claim
70 words
A method of repairing fractured bone segments in animals, comprising the step of surgically implanting adjacent said bone segments a prosthesis or implant formed of a composite of fibers selected from the group consisting of calcium phosphate and calcium aluminate, said fibers reinforcing a matrix formed from a polymer selected from the group consisting of polyglycolide, poly(DL-lactide), poly(L-lactide), polycaprolactone, polydioxanone, polyesteramides, copolyoxalates, polycarbonate, poly(glutamic-co-leucine) and blends, copolymers and terpolymers thereof.
Claim 13
Independent Claim
69 words
A method of producing a totally biodegradable composite material for prosthetic and implant devices, comprising the step of encasing an effective amount of a reinforcing material in the form of fibers selected from the group consisting of calcium phosphate and calcium aluminate in a matrix of a polymer selected from the group consisting of polyglycolide, poly(DL-lactide), poly(L-lactide), polycaprolactone, polydioxanone, polyesteramides, copolyoxalates, polycarbonate, poly(glutamic-co-leucine) and blends, copolymers and terpolymers thereof.
Claim 14
Independent Claim
69 words
A method of producing a totally biodegradable composite material for prosthetic and implant devices, comprising the step of encasing an effective amount of a reinforcing material in the form of fibers selected from the group consisting of calcium phosphate and calcium aluminate in a matrix of a polymer selected from the group consisting of polyglycolide, poly(DL-lactide), poly(L-lactide), polycaprolactone, polydioxanone, polyesteramides, copolyoxalates, polycarbonate, poly(glutamic-co-leucine) and blends, copolymers and terpolymers thereof.
Claim 15
Dependent Claim
68 words
A totally biodegradable composite material for prosthetic and implant devices, comprising: (a) from 10-90% by volume of a reinforcing material in the form of fibers selected from the group consisting of calcium phosphate and calcium aluminate; and (b) a polymer encasing said reinforcing material, said polymer being selected from the group consisting of polyglycolide, poly(DL-lactide), poly(L-lactide), polycaprolactone, polydioxanone, polyesteramides, copolyoxalates, polycarbonate, poly(glutamic-co-leucine) and blends, copolymers and terpolymers thereof.
Claim 16
Dependent Claim
68 words
A totally biodegradable composite material for prosthetic and implant devices, comprising: (a) from 10-90% by volume of a reinforcing material in the form of fibers selected from the group consisting of calcium phosphate and calcium aluminate; and (b) a polymer encasing said reinforcing material, said polymer being selected from the group consisting of polyglycolide, poly(DL-lactide), poly(L-lactide), polycaprolactone, polydioxanone, polyesteramides, copolyoxalates, polycarbonate, poly(glutamic-co-leucine) and blends, copolymers and terpolymers thereof.
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