US4832686A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method for administering interleukin-2
Assignee: Individual
•
Filing: 1986-06-24
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Granted: 1989-05-23
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Expires: 2006-06-24
Abstract
Abstract A biocompatible, biodegradable, bioerodible composite polymer matrix comprising interleukin-2 in an appropriate polymer. The polymer may be a polymer or copolymer of lactic acid, lactide, glycolide, glutamic acid, or it may be collagen or albumin. The material contains from 10 2 to 10 8 U IL-2/g of polymer. Also disclosed is a method for making the composite polyer matrix and a method for implanting the material. A soft, malleable controlled-release composite material may be used for intracranial or other implantation and may be shaped or molded to fit the site from which malignant tissue has been removed, opposing the residual tumor, complementing hemostasis, compatible with anatomical structure, and functioning as an implantable immunotherapeutic adjuvant.
Inventors
- 👤 Mark E. Anderson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 02:48
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1641; A61K9/1647; A61K38/00; A61K38/16; A61K38/17; A61K38/19; A61K38/20; A61K38/2013; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2031; A61K9/204; A61K9/48; A61K9/50; A61K9/5005; A61K9/5021; A61K9/5031
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
45 words
A method for administering interleukin-2, comprising the step of intracranially implanting into an area from which a neoplasm has been removed a controlled-release polymer matrix, comprising a biocompatible, bioerodible, hemostatic polylactic acid polymer material and interleukin-2 which material is malleable at the time of implantation.
Claim 2
Independent Claim
45 words
A method for administering interleukin-2, comprising the step of intracranially implanting into an area from which a neoplasm has been removed a controlled-release polymer matrix, comprising a biocompatible, bioerodible, hemostatic polylactic acid polymer material and interleukin-2 which material is malleable at the time of implantation.
Claim 3
Dependent Claim
10 words
The method of claim 1, wherein said neoplasm is glioblastoma.
Claim 4
Dependent Claim
33 words
The method of claim 1, further comprising the step of shaping said polymer material to fit the site from which said neoplasm was removed, thereby restoring the brain to its normal anatomical configuration.
Claim 5
Dependent Claim
14 words
The method of claim 1, wherein said polymer matrix further comprises a chemotherapeutic agent.
Claim 6
Dependent Claim
12 words
The method of claim 4, wherein said chemotherapeutic agent is a nitrosourea.
Claim 7
Dependent Claim
13 words
The method of claim 5, wherein said chemotherapeutic agent is BCNU or methyl-CCNU.
Claim 8
Dependent Claim
16 words
The method of claim 1, wherein said polymer matrix is in the form of a paste.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-05-22 | 1992-11-21 | 1993-05-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-05-22 | 1996-11-21 | 1997-05-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-05-22 | 2000-11-21 | 2001-05-23 | $7700.00 | Window Closed / Lapsed |