US4011312A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Prolonged release drug form for the treatment of bovine mastitis
Assignee: Wyeth LLC
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Filing: 1975-06-25
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Granted: 1977-03-08
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Expires: 1995-06-25
Abstract
Abstract A prolonged release drug dosage form for the treatment of bovine mastitis, specifically suited for dry cow treatment, consists of an antimicrobial agent dispersed in a matrix of a low molecular weight polyester of glycolic and lactic acids, and shaped as a cylindrical bougie for facile insertion into the teat canal. Said polyester erodes by hydrolysis in the bioenvironment, providing a continuous release of the medication throughout the desired duration of the treatment. The low molecular weight polyesters have a glycolic acid content of about 60 to 80 mole percent, a lactic acid content of about 20 to 40 mole percent, and a molecular weight less than 2000.
Inventors
- 👤 Gerald L. Reuter
- 👤 Andrew G. Tsuk
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:31
CPC Classifications
C; C08; C08G; C08G63/00; C08G63/02; C08G63/06; C08G63/08; A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0041; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2031; A61K9/204
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
93 words
A bioerodable solid dosage form for the treatment of mastitis comprising from about 30 to 70% by weight of a dosage form of at least one antimicrobial agent intimately dispersed in a polyester of glycolic and lactic acid, prepared by heating the polyester to a temperature of about 60°-80° C, dispersing therein the antimicrobial agent and thereafter rapidly cooling the admixture, the polyester having a molecular weight less than 2,000, a glycolic acid content of about 60 to 80 mole percent, and a lactic acid content of about 20 to 40 mole percent.
Claim 2
Dependent Claim
93 words
A bioerodable solid dosage form for the treatment of mastitis comprising from about 30 to 70% by weight of a dosage form of at least one antimicrobial agent intimately dispersed in a polyester of glycolic and lactic acid, prepared by heating the polyester to a temperature of about 60°-80° C, dispersing therein the antimicrobial agent and thereafter rapidly cooling the admixture, the polyester having a molecular weight less than 2,000, a glycolic acid content of about 60 to 80 mole percent, and a lactic acid content of about 20 to 40 mole percent.
Claim 3
Dependent Claim
12 words
The dosage form of claim 1 wherein the antimicrobial agent is chlortetracycline.
Claim 4
Dependent Claim
30 words
A dosage form for the treatment of mastitis comprising a suspension in a vegetable oil of about 30 to 50% by weight of the subdivided dosage form of claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-03-07 | 1980-09-06 | 1981-03-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-03-07 | 1984-09-06 | 1985-03-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-03-07 | 1988-09-06 | 1989-03-08 | $7700.00 | Window Closed / Lapsed |