Patent US5824048A successfully refreshed from Google Patents.
US5824048A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method for delivering a therapeutic substance to a body lumen
Assignee: Medtronic Inc
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Filing: 1996-10-09
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Granted: 1998-10-20
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Expires: 2016-10-09
Abstract
Abstract A method for delivering a therapeutic substance to a body lumen utilizing an intravascular stent having a coating comprising a polymer and a therapeutic substance in a solid/solid solution with the polymer. The coating comprises a first coating layer nearer the stent body having a first concentration of therapeutic substance overlaid by a second porous coating layer having a second lesser concentration of therapeutic substance. The inclusion of a porous polymer coating layer on the stent helps retain the therapeutic substance on the stent during expansion of the stent and also controls the administration of the therapeutic substance following implantation. By this method, drugs such as dexamethasone can be applied to a stent, retained on a stent during expansion of the stent and elute at a controlled rate.
Inventors
- 👤 Ronald J. Tuch
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:38
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/82; A61L; A61L31/00; A61L31/08; A61L31/10; A61L31/14; A61L31/146; A61L31/16; A61F2/95; A61F2/958; A61F2250/00; A61F2250/0058; A61F2250/0067; A61L2300/00; A61L2300/40; A61L2300/43; A61L2300/60; A61L2300/606; A61L2300/608
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
113 words
A method for delivery of a therapeutic substance to the interior of a body lumen comprising the steps of: (a) providing a generally cylindrical stent body having a surface; (b) providing a coating on the surface of the stent body comprising a polymer and a therapeutic substance in a solid/solid solution with the polymer, the coating further comprising a first coating layer nearer the stent body having a first concentration of therapeutic substance overlaid by a second porous coating layer having a second lesser concentration of therapeutic substance; (c) introducing the stent transluminally into a selected portion of the body lumen; and (d) radially expanding the stent into contact with the body lumen.
Claim 2
Independent Claim
113 words
A method for delivery of a therapeutic substance to the interior of a body lumen comprising the steps of: (a) providing a generally cylindrical stent body having a surface; (b) providing a coating on the surface of the stent body comprising a polymer and a therapeutic substance in a solid/solid solution with the polymer, the coating further comprising a first coating layer nearer the stent body having a first concentration of therapeutic substance overlaid by a second porous coating layer having a second lesser concentration of therapeutic substance; (c) introducing the stent transluminally into a selected portion of the body lumen; and (d) radially expanding the stent into contact with the body lumen.
Claim 3
Dependent Claim
17 words
A method according to claim 1 wherein the surface of the stent body is a metal surface.
Claim 4
Dependent Claim
26 words
A method according to claim 1 wherein the first coating layer is porous and the second coating layer is more porous than the first coating layer.
Claim 5
Dependent Claim
13 words
A method according to claim 1 wherein the polymer is a bioabsorbable polymer.
Claim 6
Dependent Claim
21 words
A method according to claim 4 wherein the polymer is selected from the group consisting of poly(lactic acid), poly(lactide-co-glycolide) and poly(hydroxybutyrate-co-valerate).
Claim 7
Dependent Claim
13 words
A method according to claim 1 wherein the polymer is a biostable polymer.
Claim 8
Dependent Claim
30 words
A method according to claim 6 wherein the polymer is selected from the group consisting of silicones, polyurethanes, polyesters, vinyl homopolymers and copolymers, acrylate homopolymers and copolymers, polyethers and cellulosics.
Claim 9
Dependent Claim
33 words
A method according to claim 1 wherein the therapeutic substance is selected from the group consisting of glucocorticoids, dexamethasone, dexamethasone sodium phosphate, anticoagulants, heparin, hirudin, tick anticoagulant peptide, angiopeptin, antimitotic agents, and oligonucleotides.
Claim 10
Dependent Claim
21 words
A method according to claim 1 wherein the second coating layer is the product of phase inversion precipitation of the polymer.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-10-19 | 2002-04-20 | 2002-10-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-10-19 | 2006-04-20 | 2006-10-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-10-19 | 2010-04-20 | 2010-10-20 | $7700.00 | Window Closed / Lapsed |