US5707385A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Drug loaded elastic membrane and method for delivery
Assignee: Abbott Cardiovascular Systems Inc
•
Filing: 1994-11-16
•
Granted: 1998-01-13
•
Expires: 2014-11-16
Abstract
Abstract An expandable sheath is provided for delivering a therapeutic drug in a body lumen which comprises an expandable membrane with a therapeutic drug incorporated therein. The expandable membrane is in a cylindrical configuration and mounted on the balloon portion of a catheter for intraluminal drug delivery into a patient's vascular system. The expandable membrane may also be mounted on an intravascular stent, both of which are implanted within the patient's vascular system. The therapeutic drug then diffuses into the vascular system at a controlled rate to match a specific clinical need.
Inventors
- 👤 Michael S. Williams
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:42
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/82; A61F2/92; A61M; A61M31/00; A61F2210/00; A61F2210/0076; A61F2220/00; A61F2220/0025; A61F2220/005; A61F2220/0058; A61F2230/00; A61F2230/0002; A61F2230/0004; A61F2230/0013; A61M25/00; A61M25/01; A61M2025/0183
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
185 words
An expandable sheath for delivering a therapeutic drug in a body lumen, comprising: an expandable membrane in the form of a cylindrical member and having a first end and a second end; a therapeutic drug combined with said expandable membrane; means for intraluminally delivering and expanding said expandable membrane in the body lumen so that said therapeutic drug can be eluted at a specific site in the body lumen; said expandable membrane further comprises a first layer and a second layer, said first layer and said second layer are bonded together along their edges to form a reservoir between the two layers; a plurality of apertures formed in said first layer by a laser when said expandable membrane is in a stretched condition; said therapeutic drug is loaded into said reservoir through said apertures when said membrane is in said stretched condition; and said expandable membrane retains said therapeutic drug within said reservoir when said membrane is in a relaxed condition; whereby said membrane is rolled into a cylinder so that said first edge and said second edge overlap and are attached to each other.
Claim 2
Dependent Claim
185 words
An expandable sheath for delivering a therapeutic drug in a body lumen, comprising: an expandable membrane in the form of a cylindrical member and having a first end and a second end; a therapeutic drug combined with said expandable membrane; means for intraluminally delivering and expanding said expandable membrane in the body lumen so that said therapeutic drug can be eluted at a specific site in the body lumen; said expandable membrane further comprises a first layer and a second layer, said first layer and said second layer are bonded together along their edges to form a reservoir between the two layers; a plurality of apertures formed in said first layer by a laser when said expandable membrane is in a stretched condition; said therapeutic drug is loaded into said reservoir through said apertures when said membrane is in said stretched condition; and said expandable membrane retains said therapeutic drug within said reservoir when said membrane is in a relaxed condition; whereby said membrane is rolled into a cylinder so that said first edge and said second edge overlap and are attached to each other.
Claim 3
Dependent Claim
30 words
The expandable sheath of claim 1, wherein said membrane is rolled into a cylinder so that said first edge and said second edge abut and are attached to each other.
Claim 4
Dependent Claim
32 words
The expandable sheath of claim 1, wherein said expandable membrane is attached to a balloon portion of a catheter for intravascular transport and delivery to a specific site in the body lumen.
Claim 5
Dependent Claim
37 words
The expandable sheath of claim 3, wherein said balloon portion of said catheter expands, thereby expanding said expandable membrane and forcing said therapeutic drug in said reservoir to diffuse through said apertures and into the lumen wall.
Claim 6
Dependent Claim
146 words
An expandable sheath for delivering a therapeutic drug in a body lumen, comprising: an expandable membrane having a first layer and a second layer, said first layer and said second layer affixed to each other along their edges to form a drug-containing reservoir between the two layers; a plurality of apertures on said first layer through which the therapeutic drug can diffuse from within said drug-containing reservoir, said plurality of apertures remaining open when said first layer is in a stretched condition and said apertures tightly closing when said first layer is in a relaxed condition; and a catheter having a proximal end and a distal end, the catheter further having an expandable balloon portion at the distal end and an intravascular stent mounted thereon, said expandable membrane is affixed to said stent by rolling said expandable membrane to form a cylinder around said intravascular stent.
Claim 7
Dependent Claim
146 words
An expandable sheath for delivering a therapeutic drug in a body lumen, comprising: an expandable membrane having a first layer and a second layer, said first layer and said second layer affixed to each other along their edges to form a drug-containing reservoir between the two layers; a plurality of apertures on said first layer through which the therapeutic drug can diffuse from within said drug-containing reservoir, said plurality of apertures remaining open when said first layer is in a stretched condition and said apertures tightly closing when said first layer is in a relaxed condition; and a catheter having a proximal end and a distal end, the catheter further having an expandable balloon portion at the distal end and an intravascular stent mounted thereon, said expandable membrane is affixed to said stent by rolling said expandable membrane to form a cylinder around said intravascular stent.
Claim 8
Dependent Claim
43 words
The expandable sheath of claim 5, wherein said expandable balloon is expanded from a first diameter to a second enlarged diameter thereby expanding said stent and said expandable membrane so that said stent and said expandable membrane are implanted in the body lumen.
Claim 9
Dependent Claim
51 words
The expandable sheath of claim 6, wherein said plurality of apertures on said first layer open when said expandable membrane is expanded by said expandable balloon and intravascular stent, so that as said plurality of apertures open the therapeutic drug will diffuse from within said drug-containing reservoir to said body lumen.
Claim 10
Dependent Claim
177 words
An expandable sheath for delivering a therapeutic drug in a body lumen, comprising: an expandable membrane having a first layer and a second layer, said first layer and said second layer affixed to each other along their edges to form a drug-containing reservoir between the two layers; a plurality of apertures on said first layer through which the therapeutic drug can diffuse from within said drug-containing reservoir, said plurality of apertures remaining open when said first layer is in a stretched condition and said apertures tightly closing when said first layer is in a relaxed condition; and a catheter having a proximal end and a distal end, the catheter further having an expandable balloon portion at its distal end and an intravascular stent mounted thereon, said expandable membrane is affixed to said stent by rolling said expandable membrane to form a cylinder around said intravascular stent; said second layer has an inner surface in contact with blood flow, said inner surface loaded with a sustained release antithrombotic drug for diffusing into the blood at a predetermined rate.
Claim 11
Dependent Claim
177 words
An expandable sheath for delivering a therapeutic drug in a body lumen, comprising: an expandable membrane having a first layer and a second layer, said first layer and said second layer affixed to each other along their edges to form a drug-containing reservoir between the two layers; a plurality of apertures on said first layer through which the therapeutic drug can diffuse from within said drug-containing reservoir, said plurality of apertures remaining open when said first layer is in a stretched condition and said apertures tightly closing when said first layer is in a relaxed condition; and a catheter having a proximal end and a distal end, the catheter further having an expandable balloon portion at its distal end and an intravascular stent mounted thereon, said expandable membrane is affixed to said stent by rolling said expandable membrane to form a cylinder around said intravascular stent; said second layer has an inner surface in contact with blood flow, said inner surface loaded with a sustained release antithrombotic drug for diffusing into the blood at a predetermined rate.
References Cited (Backward Citations)
US4346028A
Cited
US4417576A
Cited
US4423725A
Cited
US4902289A
Cited
US5197977A
Cited
US4633873A
Cited
US4879135A
Cited
US4732152A
Cited
US4718907A
Cited
US4776337A
Cited
US4739762A
Cited
US4776337B1
Cited
US4733665A
Cited
US4739762B1
Cited
US4733665B1
Cited
US4733665C2
Cited
DE3640745A1
Cited
US4768507A
Cited
US4878906A
Cited
US4723549A
Cited
US4722335A
Cited
US4816339A
Cited
US5059211A
Cited
US5306286A
Cited
US4877030A
Cited
US5192311A
Cited
US5085629A
Cited
US5163958A
Cited
US5289831A
Cited
US5062829A
Cited
US5108755A
Cited
US5100429A
Cited
US4994033A
Cited
US5084065A
Cited
US5108370A
Cited
US5234456A
Cited
US5156623A
Cited
US5290271A
Cited
US5199951A
Cited
WO1991017789A1
Cited
US5279594A
Cited
US5236447A
Cited
US5163952A
Cited
US5330500A
Cited
US5163951A
Cited
US5413597A
Cited
US5356433A
Cited
WO1993006792A1
Cited
US5151105A
Cited
US5234457A
Cited
US5282860A
Cited
EP0567788A1
Cited
US5383927A
Cited
EP0649537A1
Cited
US5342348A
Cited
EP0604022A1
Cited
US5419760A
Cited
EP0621017A1
Cited
US5458605A
Cited
US5439446A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-01-12 | 2001-07-14 | 2002-01-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-01-12 | 2005-07-14 | 2006-01-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-01-12 | 2009-07-14 | 2010-01-13 | $7700.00 | Window Closed / Lapsed |