US5176907A
Expired / Lapsed
US
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Biocompatible and biodegradable poly (phosphoester-urethanes)
Assignee: Johns Hopkins University
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Filing: 1991-08-13
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Granted: 1993-01-05
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Expires: 2011-08-13
Abstract
Abstract Biocompatible and biodegradable poly(phosphoester-urethanes), compositions comprising the poly(phosphoester-urethanes), and methods of use as a drug delivery device and an implant.
Inventors
- 👤 Kam W. Leong
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 23:24
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0024; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/59; A61K47/60; A61K47/605; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2031; A61L; A61L27/00; A61L27/14; A61L27/18; A61L27/50; A61L27/58; C; C08; C08G; C08G18/00; C08G18/06; C08G18/28; C08G18/30; C08G18/38; C08G18/3878; C08G18/388; C08G18/40; C08G18/48; C08G18/50; C08G18/5075; C08G18/5078; C08G2230/00
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
196 words
A biocompatible and biodegradable poly-(phosphoester-urethane) of the formula: ##STR6## wherein R is hydrogen, alkyl having C 1 -C 12 , or a residue of a therapeutic agent capable of being released in a physiological environment; R 1 is selected from the group consisting of C 2 -C 20 alkylene, C 6 -C 20 arylene, C 7 -C 20 aralkylene, C 6 -C 20 cycloalkylene, and a divalent residue of an amino acid, an amino acid derivative or an amino acid mimetic; R 2 is selected from the group consisting of C 2 -C 6 polyalkylene having a molecular weight of from about 500 to about 2000, C 2 -C 6 polyalkenylene having a molecular weight of from about 500 to about 2000, C 7 -C 20 aralkylene, (R 3 O) l wherein R 3 is C 2 -C 6 alkylene or acyl having from 2 to 6 carbons, and l is an integer of from 5 to 30, and ##STR7## wherein R 4 is hydrogen or alkyl having C 1 -C 12 ; n is an integer of from 2 to 6; and m is an integer of from about 10 to about 10 5 .
Claim 2
Dependent Claim
196 words
A biocompatible and biodegradable poly-(phosphoester-urethane) of the formula: ##STR6## wherein R is hydrogen, alkyl having C 1 -C 12 , or a residue of a therapeutic agent capable of being released in a physiological environment; R 1 is selected from the group consisting of C 2 -C 20 alkylene, C 6 -C 20 arylene, C 7 -C 20 aralkylene, C 6 -C 20 cycloalkylene, and a divalent residue of an amino acid, an amino acid derivative or an amino acid mimetic; R 2 is selected from the group consisting of C 2 -C 6 polyalkylene having a molecular weight of from about 500 to about 2000, C 2 -C 6 polyalkenylene having a molecular weight of from about 500 to about 2000, C 7 -C 20 aralkylene, (R 3 O) l wherein R 3 is C 2 -C 6 alkylene or acyl having from 2 to 6 carbons, and l is an integer of from 5 to 30, and ##STR7## wherein R 4 is hydrogen or alkyl having C 1 -C 12 ; n is an integer of from 2 to 6; and m is an integer of from about 10 to about 10 5 .
Claim 3
Dependent Claim
36 words
The poly-(phosphoester-urethane) according to claim 1, wherein R 1 is 4,4'-diphenylmethane, R 2 is (R 3 O) l wherein R 3 is ethylene, l is 9, n is 2, and m is about 10 4 .
Claim 4
Dependent Claim
40 words
The poly-(phosphoester-urethane) according to claim 1, wherein R 1 is 2-methyl-1,3-phenylene, R 2 is selected from isopropylidene-1,4-biphenylene and (R 3 O) l wherein R 3 is ethylene, l is 9, n is 2, and m is about 10 4 .
Claim 5
Dependent Claim
14 words
The poly-(phosphoester-urethane) according to claim 1, wherein R 1 is a residue of L-lysine.
Claim 6
Dependent Claim
32 words
The poly-(phosphoester-urethane) according to claim 4, wherein R 1 is 1-alkoxycarbonyl-1,5-pentylene, R 2 is 1,4-phenylene-dimethylene or (R 3 O) l wherein R 3 is ethylene, l is 9, and n is 2.
Claim 7
Dependent Claim
11 words
The poly-(phosphoester-urethane) according to claim 5, wherein R 1 is ethoxycarbonyl-1,5-pentylene.
Claim 8
Dependent Claim
43 words
The poly-(phosphoester-urethane) according to any one of claims 1-6, wherein R is a therapeutic agent selected from the group consisting of a chemotherapeutic agent, a proteinous drug, a biological response modifier, a lectin, a radioisotope-labeled chemical, and a human or veterinary biological product.
Claim 9
Dependent Claim
16 words
The poly-(phosphoester-urethane) according to claim 7, wherein the therapeutic agent is 5-fluorouracil or a derivative thereof.
Claim 10
Dependent Claim
18 words
The poly-(phosphoester-urethane) according to claim 1, wherein R is hydrogen or alkyl having C 1 -C 6 .
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-01-05 | 1996-07-06 | 1997-01-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-01-05 | 2000-07-06 | 2001-01-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-01-05 | 2004-07-06 | 2005-01-05 | $7700.00 | Window Closed / Lapsed |