US5464650A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Intravascular stent and method
Assignee: LATHAM DANIEL W
•
Filing: 1993-04-26
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Granted: 1995-11-07
•
Expires: 2013-04-26
Abstract
Abstract A method for making an intravascular stent by applying to the body of a stent a solution which includes a solvent, a polymer dissolved in the solvent and a therapeutic substance dispersed in the solvent and then evaporating the solvent. The inclusion of a polymer in intimate contact with a drug on the stent allows the drug to be retained on the stent during expansion of the stent and also controls the administration of drug following implantation. The adhesion of the coating and the rate at which the drug is delivered can be controlled by the selection of an appropriate bioabsorbable or biostable polymer and the ratio of drug to polymer in the solution. By this method, drugs such as dexamethasone can be applied to a stent, retained on a stent during expansion of the stent and elute at a controlled rate.
Inventors
- 👤 Eric P. Berg
- 👤 Ronald J. Tuch
- 👤 Michael Dror
- 👤 Rodney G. Wolff
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 22:31
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/82; A61L; A61L31/00; A61L31/08; A61L31/10; A61L31/14; A61L31/146; A61L31/16; A61F2/95; A61F2/958; A61F2210/00; A61F2210/0004; A61F2240/00; A61F2240/001; A61F2250/00; A61F2250/0058; A61F2250/0067; A61L2300/00; A61L2300/20; A61L2300/22; A61L2300/222; A61L2300/40; A61L2300/416; A61L2300/42; A61L2300/60; A61L2300/602; A61L2300/606; A61L2300/608
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
99 words
A method for making an intravascular stent comprising the steps of: (a) providing a cylindrical, radially expandable stent body; (b) applying to the stent body by spraying a solution which includes a solvent, a polymer dissolved in the solvent and a therapeutic substance dispersed in the solvent; (c) evaporating the solvent; (d) repeating application and evaporating steps (b) and (c) to provide an amount of polymer and therapeutic substance on the stent body; and (e) radially expanding the stent body and applied polymer and therapeutic substance such that the polymer and therapeutic substance are retained on the stent body.
Claim 2
Independent Claim
99 words
A method for making an intravascular stent comprising the steps of: (a) providing a cylindrical, radially expandable stent body; (b) applying to the stent body by spraying a solution which includes a solvent, a polymer dissolved in the solvent and a therapeutic substance dispersed in the solvent; (c) evaporating the solvent; (d) repeating application and evaporating steps (b) and (c) to provide an amount of polymer and therapeutic substance on the stent body; and (e) radially expanding the stent body and applied polymer and therapeutic substance such that the polymer and therapeutic substance are retained on the stent body.
Claim 3
Dependent Claim
14 words
A method according to claim 1, wherein the stent body has a metal surface.
Claim 4
Dependent Claim
14 words
A method according to claim 1, wherein the stent body has a polymeric surface.
Claim 5
Dependent Claim
25 words
A method according to claim 1 wherein the ratio of drug to dissolved polymer in the solution is varied in some of the application steps.
Claim 6
Dependent Claim
13 words
A method according to claim 1 wherein the polymer is a biostable polymer.
Claim 7
Dependent Claim
30 words
A method according to claim 5 wherein the polymer is selected from the group consisting of silicones, polyurethanes, polyesters, vinyl homopolymers and copolymers, acrylate homopolymers and copolymers, polyethers and cellulosics.
Claim 8
Dependent Claim
26 words
A method according to claim 1 wherein the ratio of drug to dissolved polymer in the solution is in the range of about 10:1 to 1:100.
Claim 9
Dependent Claim
32 words
A method according to claim 1 wherein the drug is selected from the groups consisting of glucocorticoids, dexamethasone, dexamethasone sodium phosphate, anticoagulants, heparin, hirudin, tick anticoagulant peptide, angiopeptin, antimitotic agents, and oligonucleotides.
Claim 10
Independent Claim
98 words
A method for making an intravascular stent comprising the steps of: (a) providing a cylindrical, radially expandable stent body; (b) applying to the stent body a solution which includes a solvent, a bioabsorbable polymer dissolved in the solvent and a therapeutic substance dispersed in the solvent; (c) evaporating the solvent; (d) repeating application and evaporating steps (b) and (c) to provide an amount of polymer and therapeutic substance on the stent body; and (e) radially expanding the stent body and applied polymer and therapeutic substance such that the polymer and therapeutic substance are retained on the stent body.
Claim 11
Independent Claim
98 words
A method for making an intravascular stent comprising the steps of: (a) providing a cylindrical, radially expandable stent body; (b) applying to the stent body a solution which includes a solvent, a bioabsorbable polymer dissolved in the solvent and a therapeutic substance dispersed in the solvent; (c) evaporating the solvent; (d) repeating application and evaporating steps (b) and (c) to provide an amount of polymer and therapeutic substance on the stent body; and (e) radially expanding the stent body and applied polymer and therapeutic substance such that the polymer and therapeutic substance are retained on the stent body.
Claim 12
Dependent Claim
21 words
A method according to claim 9 wherein the polymer is selected from the group consisting of poly(L-lactic acid), poly(lactide-co-glycolide) and poly(hydroxybutyrate-co-valerate).
Claim 13
Dependent Claim
14 words
A method according to claim 9 wherein the stent body has a metal surface.
Claim 14
Dependent Claim
14 words
A method according to claim 9 wherein the stent body has a polymeric surface.
Claim 15
Dependent Claim
13 words
A method according to claim 9 wherein the solution is applied by spraying.
Claim 16
Dependent Claim
13 words
A method according to claim 9 wherein the solution is applied by immersion.
Claim 17
Dependent Claim
27 words
A method according to claim 9 wherein the ratio of drug to dissolved polymer in the solution is varied in some of the plurality of application steps.
Claim 18
Dependent Claim
26 words
A method according to claim 9 wherein the ratio of drug to dissolved polymer in the solution is in the range of about 10:1 to 1:100.
Claim 19
Dependent Claim
32 words
A method according to claim 9 wherein the drug is selected from the groups consisting of glucocorticoids, dexamethasone, dexamethasone sodium phosphate, anticoagulants, heparin, hirudin, tick anticoagulant peptide, angiopeptin, antimitotic agents, and oligonucleotides.
Claim 20
Independent Claim
75 words
A method for making an intravascular stent comprising the steps of: (a) providing a cylindrical, radially expandable, metal stent body; (b) spraying onto the stent body a solution which includes a solvent, a bioabsorbable polymer dissolved in the solvent and a glucocorticoid dispersed in the solvent; and (c) evaporating the solvent; and (d) radially expanding the stent body and applied polymer and glucocorticoid such that the polymer and glucocorticoid are retained on the stent body.
Claim 21
Independent Claim
75 words
A method for making an intravascular stent comprising the steps of: (a) providing a cylindrical, radially expandable, metal stent body; (b) spraying onto the stent body a solution which includes a solvent, a bioabsorbable polymer dissolved in the solvent and a glucocorticoid dispersed in the solvent; and (c) evaporating the solvent; and (d) radially expanding the stent body and applied polymer and glucocorticoid such that the polymer and glucocorticoid are retained on the stent body.
Claim 22
Dependent Claim
19 words
A method according to claim 18 wherein the solution is applied in a plurality of application and drying steps.
Claim 23
Dependent Claim
27 words
A method according to claim 19 wherein the ratio of drug to dissolved polymer in the solution is varied in some of the plurality of application steps.
Claim 24
Dependent Claim
25 words
A method according to claim 18 wherein the polymer is selected from the group consisting of poly(L-lactic acid), poly(lactide-co-glycolide), fibrin, silicone, polyurethane, and poly(phosphoester urethane).
Claim 25
Dependent Claim
11 words
A method according to claim 18 wherein the glucocorticoid is dexamethasone.
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1998-11-06 | 1999-05-08 | 1999-11-07 | $2000.00 | Window Closed / Lapsed |
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