US4894231A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Therapeutic agent delivery system
Assignee: Ipsen Bioscience Inc
•
Filing: 1987-07-28
•
Granted: 1990-01-16
•
Expires: 2007-07-28
Abstract
Abstract A delivery system for agents, such as therapeutic agents, or other substances includes a biodegradable polymer and the agent or substance. The delivery system is coated with a barrier substance that decreases the quantity of the agent release from the system, compared to the quantity of the agent release from a system not coated with the substance, in the forty-eight hours period immediately subsequent to the parenteral injection or implantation of the system into a living person or annimal.
Inventors
- 👤 Jacques-Pierre Moreau
- 👤 Judith P. Kitchell
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 23:23
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0024; A61K9/48; A61K9/50; A61K9/5005; A61K9/5021; A61K9/5031
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
107 words
A therapeutic agent delivery system comprising a biodegradable polymer and a therapeutic agent, said delivery system being coated with a barrier substance that decreases the quantity of said agent released from said system, compared with the quantity of said agent released from a said system not coated with said barrier substance, in the forty-eight hours subsequent to the parenteral injection or implantation of said system into a living person or animal, said barrier substance being selected from the group consisting of a paraffin, beeswax, or a silicone oil and being adapted to dissipate from said delivery system within a short time period after said injection or implantation.
Claim 2
Dependent Claim
107 words
A therapeutic agent delivery system comprising a biodegradable polymer and a therapeutic agent, said delivery system being coated with a barrier substance that decreases the quantity of said agent released from said system, compared with the quantity of said agent released from a said system not coated with said barrier substance, in the forty-eight hours subsequent to the parenteral injection or implantation of said system into a living person or animal, said barrier substance being selected from the group consisting of a paraffin, beeswax, or a silicone oil and being adapted to dissipate from said delivery system within a short time period after said injection or implantation.
Claim 3
Dependent Claim
17 words
The coated therapeutic agent delivery system of claim 1 wherein said barrier substance is a silicone oil.
Claim 4
Dependent Claim
25 words
The coated therapeutic agent delivery system of claim 2 wherein said silicone oil has a viscosity of between 10 2 centipoise and 10 4 centipoise.
Claim 5
Dependent Claim
23 words
The coated therapeutic agent delivery system of claim 2 wherein said silicone oil has a viscosity of between 500 centipoise and 2000 centipoise.
Claim 6
Independent Claim
108 words
A method of providing a coated therapeutic agent delivery system comprising coating a therapeutic agent delivery system comprising a biodegradable polymer and therapeutic agent with a barrier substance that decreases the quantity of said agent released from said system, compared with the quantity of said agent released from a said system not coated with said substance, in the forty-eight hours subsequent to the parental injection or implantation of said system into a living person or animal, said barrier substance being selected from the group consisting of a paraffin, beeswax, or a silicone oil; and treating said delivery system to remove some but not all of said barrier substance.
Claim 7
Independent Claim
108 words
A method of providing a coated therapeutic agent delivery system comprising coating a therapeutic agent delivery system comprising a biodegradable polymer and therapeutic agent with a barrier substance that decreases the quantity of said agent released from said system, compared with the quantity of said agent released from a said system not coated with said substance, in the forty-eight hours subsequent to the parental injection or implantation of said system into a living person or animal, said barrier substance being selected from the group consisting of a paraffin, beeswax, or a silicone oil; and treating said delivery system to remove some but not all of said barrier substance.
Claim 8
Dependent Claim
13 words
The method of claim 5 wherein said barrier substance is a silicone oil.
Claim 9
Dependent Claim
16 words
The method of claim 5 wherein said treating comprises washing said delivery system with a solvent.
Claim 10
Dependent Claim
16 words
The coated delivery system of claim 1 wherein said short period is 5 days or less.
Claim 11
Dependent Claim
16 words
The coated delivery system of claim 8 wherein said short period is 2 days or less.
References Cited (Backward Citations)
US3279996A
Cited
US3854480A
Cited
US4230686A
Cited
US4351337A
Cited
US3944064A
Cited
US4159322A
Cited
US4622244A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-01-15 | 1993-07-17 | 1994-01-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-01-15 | 1997-07-17 | 1998-01-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-01-15 | 2001-07-17 | 2002-01-16 | $7700.00 | Window Closed / Lapsed |