US5770255A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Anti-microbial coating for medical devices
Assignee: Nucryst Pharmaceuticals Corp Canada
•
Filing: 1993-09-29
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Granted: 1998-06-23
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Expires: 2013-09-29
Abstract
Abstract Anti-microbial coatings and method of forming same on medical devices. The coatings are formed by depositing a biocompatible metal by physical vapor deposition techniques to produce atomic disorder in the coating such that a sustained release of metal ions sufficient to produce an anti-microbial effect is achieved. Preferred deposition conditions to achieve atomic disorder include a lower than normal substrate temperature, and one or more of a higher than normal working gas pressure and a lower than normal angle of incidence of coating flux.
Inventors
- 👤 Robert E. Burrell
- 👤 Larry Roy Morris
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:49
CPC Classifications
C; C23; C23C; C23C14/00; C23C14/22; C23C14/225; A; A61; A61L; A61L17/00; A61L17/14; A61L17/145; A01; A01N; A01N59/00; A01N59/16; A61L27/00; A61L27/28; A61L27/30; A61L27/306; A61L27/50; A61L27/54; A61L29/00; A61L29/08; A61L29/10; A61L29/106; A61L29/14; A61L29/16; A61L31/00; A61L31/14; A61L31/16; C23C14/0021; C23C14/0036; C23C14/02; C23C14/024; C23C14/025; C23C14/06; C23C14/0688; C23C14/08; C23C14/086; C23C14/14; C23C14/16; C23C14/20; C23C14/205; C23C14/34; C23C14/35; C23C14/58; C23C14/5873; C23C14/588; A61B; A61B18/00; A61B2018/00053; A61B2018/00107; A61B2018/00119; A61L2300/00; A61L2300/10; A61L2300/102; A61L2300/104; A61L2300/40; A61L2300/404; A61L2300/60; A61L2300/602; A61L2300/606; H; H01; H01H; H01H2300/00; H01H2300/014; Y; Y10; Y10S; Y10S977/00; Y10S977/70; Y10S977/778; Y10S977/781; Y10S977/84; Y10S977/89; Y10S977/891; Y10S977/902; Y10S977/904; Y10S977/931
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
159 words
A method for forming an anti-microbial coating on a medical device intended for use in contact with an alcohol or water based electrolyte, comprising: depositing a coating containing one or more of the metals selected from the group consisting of Ag, Au, Pt, Pd, Hg, Sn, Cu, Sb, Bi and Zn or alloys of two or more of these metals on a surface of the medical device by physical vapor deposition to provide a thin film of the metal, in a crystalline form, having atomic disorder formed throughout the thickness of the film such that the coating, in contact with an alcohol or a water based electrolyte, provides a release of the metal ions at a concentration sufficient to provide a localized anti-microbial effect which is sufficient to generate a zone of inhibition of at least 6.3 mm s determined by incubating a coating on a bacterial lawn on a nutrient-containing agar medium and measuring the zone of clearing.
Claim 2
Independent Claim
159 words
A method for forming an anti-microbial coating on a medical device intended for use in contact with an alcohol or water based electrolyte, comprising: depositing a coating containing one or more of the metals selected from the group consisting of Ag, Au, Pt, Pd, Hg, Sn, Cu, Sb, Bi and Zn or alloys of two or more of these metals on a surface of the medical device by physical vapor deposition to provide a thin film of the metal, in a crystalline form, having atomic disorder formed throughout the thickness of the film such that the coating, in contact with an alcohol or a water based electrolyte, provides a release of the metal ions at a concentration sufficient to provide a localized anti-microbial effect which is sufficient to generate a zone of inhibition of at least 6.3 mm s determined by incubating a coating on a bacterial lawn on a nutrient-containing agar medium and measuring the zone of clearing.
Claim 3
Dependent Claim
22 words
The method as set froth in claim 1 wherein the deposition is performed by vacuum evaporation, sputtering, magnetron sputtering or ion plating.
Claim 4
Dependent Claim
45 words
The method as set forth in claim 2, wherein the deposition is performed at a temperature such that a ratio of the temperature of the surface being coated to the melting point of the metal, in degrees Kelvin, is maintained at less than about 0.5.
Claim 5
Independent Claim
36 words
The method as set forth in claims 2 or 3, wherein the deposition is performed such that an angle of incidence of coating flux on the medical device to be coated is less than about 75°.
Claim 6
Independent Claim
48 words
The method as set forth in claims 2 or 3, wherein the deposition is performed by vacuum evaporation at a pressure greater than about 0.1 mT, by arc evaporation at a pressure greater than about 100 mT, or by pressure plating at a pressure greater than 200 mT.
Claim 7
Independent Claim
28 words
The method as set forth in claims 2 or 3, wherein the deposition is performed by sputtering at a working gas pressure of greater than about 75 mT.
Claim 8
Independent Claim
29 words
The method as set forth in claims 2 or 3, wherein the deposition is performed by ion plating at a working gas pressure of greater than about 10 mT.
Claim 9
Independent Claim
29 words
The method as set forth in claims 2 or 3, wherein the deposition is performed by ion plating at a working gas pressure of greater than about 200 mT.
Claim 10
Independent Claim
36 words
The method as set forth in claims 2 or 3, wherein the metal is selected from the group consisting of Ag, Au, Pt, Pd, Cu, and Zn or alloys of two or more of said materials.
Claim 11
Independent Claim
22 words
The method as set forth in claims 2 or 3, wherein the metal is a noble metal or a noble metal alloy.
Claim 12
Independent Claim
24 words
The method as set forth in claims 2 or 3, wherein the metal is Ag, Au or Pd or an alloy of these metals.
Claim 13
Dependent Claim
27 words
The method as set forth in claim 3, wherein the deposition is performed by magnetron sputtering at a working gas pressure of greater than about 30 mT.
Claim 14
Dependent Claim
18 words
The method as set forth in claim 3, wherein the metal is selected from Ag or Ag alloys.
Claim 15
Independent Claim
231 words
A method of forming an anti-microbial coating on a medical device intended for use in contact with an alcohol or water based electrolyte, comprising: depositing a coating containing one or more of the metals selected from the group consisting of Ag, Au, Pt, Pd, Hg, Sn, Cu, Sb, Bi and Zn or alloys of two or more of these metals on a surface of the medical device by physical vapor deposition conditions selected from vacuum evaporation at a pressure of greater than about 0.1 mT, arc evaporation at a pressure greater than about 100 mT, pressure plating at a pressure greater than 200 mT, sputtering at a working gas pressure of greater than about 75 mT, magnetron sputtering at a working gas pressure of greater than about 10 mT, or ion plating at a working gas pressure of greater than about 200 mT, to provide a thin film of the metal, in a crystalline form, having atomic disorder formed throughout the thickness of the film such that the coating, in contact with an alcohol or a water based electrolyte, provides a release of the metal ions at a concentration sufficient to provide a localized anti-microbial effect which is sufficient to generate a zone of inhibition of at least 6.3 mm as determined by incubating a coating on a bacterial lawn on a nutrient-containing agar medium and measuring the zone of clearing.
Claim 16
Independent Claim
231 words
A method of forming an anti-microbial coating on a medical device intended for use in contact with an alcohol or water based electrolyte, comprising: depositing a coating containing one or more of the metals selected from the group consisting of Ag, Au, Pt, Pd, Hg, Sn, Cu, Sb, Bi and Zn or alloys of two or more of these metals on a surface of the medical device by physical vapor deposition conditions selected from vacuum evaporation at a pressure of greater than about 0.1 mT, arc evaporation at a pressure greater than about 100 mT, pressure plating at a pressure greater than 200 mT, sputtering at a working gas pressure of greater than about 75 mT, magnetron sputtering at a working gas pressure of greater than about 10 mT, or ion plating at a working gas pressure of greater than about 200 mT, to provide a thin film of the metal, in a crystalline form, having atomic disorder formed throughout the thickness of the film such that the coating, in contact with an alcohol or a water based electrolyte, provides a release of the metal ions at a concentration sufficient to provide a localized anti-microbial effect which is sufficient to generate a zone of inhibition of at least 6.3 mm as determined by incubating a coating on a bacterial lawn on a nutrient-containing agar medium and measuring the zone of clearing.
Claim 17
Dependent Claim
45 words
The method as set forth in claim 14, wherein the deposition is performed at a temperature such that a ratio of the temperature of the surface being coated to the melting point of the metal, in degrees Kelvin, is maintained at less than about 0.5.
Claim 18
Dependent Claim
34 words
The method as set forth in claim 15, wherein the deposition is performed such that an angle of incidence of coating flux on the medical device to be coated is less than about 75°.
Claim 19
Dependent Claim
34 words
The method as set forth in claim 15, wherein the metal is selected from the group consisting of Ag, Au, Pt, Pd, Cu, and Zn or alloys of two or more of said metals.
Claim 20
Dependent Claim
20 words
The method as set forth in claim 15, wherein the metal is a noble metal or a noble metal alloy.
Claim 21
Dependent Claim
26 words
The method as set forth in claim 15, wherein the metal is Ag, Au or Pd, or an alloy containing one or more of these metals.
Claim 22
Dependent Claim
27 words
The method as set forth in claim 15, wherein the deposition is performed by magnetron sputtering at a working gas pressure of greater than about 30 mT.
Claim 23
Dependent Claim
18 words
The method as set forth in claim 15, wherein the metal is selected from Ag or Ag alloys.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-06-22 | 2001-12-22 | 2002-06-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-06-22 | 2005-12-22 | 2006-06-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-06-22 | 2009-12-22 | 2010-06-23 | $7700.00 | Window Closed / Lapsed |