US4846834A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method for promoting tissue adhesion to soft tissue implants
Assignee: Clemson University
•
Filing: 1988-03-16
•
Granted: 1989-07-11
•
Expires: 2008-03-16
Abstract
Abstract A soft tissue implant comprises a flexible main body portion, having tissue-facing surfaces and a thin layer of pure titanium covering the tissue-facing surfaces. A method of promoting tissue adhesion of a soft tissue host to the tissue-facing surfaces of a soft tissue implant comprising a strip of polyethylene terephthalate velour comprises the steps of cleaning the strip with a low-residue detergent and rinsing same with fresh distilled water; refluxing the strip in distilled water for one hour at a temperature of less than 30° C.; drying the strip in a room-temperature desicator for several days; sterilizing the strip and packaging same; degasing the strip and storing same in a dust-free environment; removing the strip from the packaging and mounting the strip in a vacuum evaporator at an approximate angle of incidence of 90° from a pure titanium metal evaporant; evacuating the vacuum evaporator to a vacuum of about 2×10 -5 Torr; evaporating the titanium by direct resistence heating same; coating the strip with a layer of pure titanium on the order of one micron thick; and resterilizing and implanting the titanium-coated strip into the tissue host.
Inventors
- 👤 Andreas F. von Recum
- 👤 Francis W. Cooke
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 16:28
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/0077; A61L; A61L27/00; A61L27/28; A61L27/30; A61L27/306; A61F2310/00; A61F2310/00389; A61F2310/00395; A61F2310/00407
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
82 words
A method of promoting tissue adhesion of a host's soft tissue bed to a soft tissue implant having a main body portion with tissue-facing surfaces, the method comprising the steps of: coating the tissue-facing surfaces of the main body portion with a layer of pure titanium; sterilizing the titanium coated implant; forming a thin layer of titanium oxide over the pure titanium layer as the free surface of the implant; and implanting the titanium coated implant into the host's soft tissue bed.
Claim 2
Independent Claim
82 words
A method of promoting tissue adhesion of a host's soft tissue bed to a soft tissue implant having a main body portion with tissue-facing surfaces, the method comprising the steps of: coating the tissue-facing surfaces of the main body portion with a layer of pure titanium; sterilizing the titanium coated implant; forming a thin layer of titanium oxide over the pure titanium layer as the free surface of the implant; and implanting the titanium coated implant into the host's soft tissue bed.
Claim 3
Dependent Claim
25 words
A method as in claim 1, wherein: said coating step comprises vapor deposition of pure titanium on the tissue-facing surfaces of the main body portion.
Claim 4
Dependent Claim
19 words
A method as in claim 2, wherein: said vapor deposition includes direct resistance heating of a pure titanium structure.
Claim 5
Independent Claim
83 words
A method of promoting tissue adhesion of a soft tissue bed to the tissue-facing surfaces of a soft tissue implant wherein the tissue-facing surfaces are formed of a flexible polymeric material, the method comprising the steps of: coating the tissue-facing surfaces with a layer of pure titanium; sterilizing the titanium coated implant; forming a thin layer of titanium oxide over the pure titanium layer as the free surface of the implant; and implanting the titanium coated implant into the host's soft tissue bed.
Claim 6
Independent Claim
83 words
A method of promoting tissue adhesion of a soft tissue bed to the tissue-facing surfaces of a soft tissue implant wherein the tissue-facing surfaces are formed of a flexible polymeric material, the method comprising the steps of: coating the tissue-facing surfaces with a layer of pure titanium; sterilizing the titanium coated implant; forming a thin layer of titanium oxide over the pure titanium layer as the free surface of the implant; and implanting the titanium coated implant into the host's soft tissue bed.
Claim 7
Dependent Claim
20 words
A method as in claim 4, wherein: said coating step comprises vapor deposition of pure titanium on the tissue-facing surfaces.
Claim 8
Independent Claim
84 words
A method of promoting tissue adhesion of a host's soft tissue bed to the tissue-facing surfaces of a soft tissue implant, wherein the tissue-facing surfaces are formed of a porous polymeric material, the method comprising the steps of: coating the tissue-facing surfaces with a layer of pure titanium; sterilizing the titanium coated implant; forming a thin layer of titanium oxide over the pure titanium layer as the free surface of the implant; and implanting the titanium coated implant into the host's soft tissue bed.
Claim 9
Independent Claim
84 words
A method of promoting tissue adhesion of a host's soft tissue bed to the tissue-facing surfaces of a soft tissue implant, wherein the tissue-facing surfaces are formed of a porous polymeric material, the method comprising the steps of: coating the tissue-facing surfaces with a layer of pure titanium; sterilizing the titanium coated implant; forming a thin layer of titanium oxide over the pure titanium layer as the free surface of the implant; and implanting the titanium coated implant into the host's soft tissue bed.
Claim 10
Dependent Claim
27 words
A method as in claim 6, wherein: said coating step comprises vapor deposition of pure titanium on the porous polymeric tissue-facing surfaces of the soft tissue implant.
Claim 11
Independent Claim
105 words
A method of promoting tissue adhesion of a host's soft tissue bed to the tissue-facing surfaces of a soft tissue implant wherein the tissue-facing surfaces are formed of a polymeric material having a roughened surface texture, the roughness being hills and valleys in a range of 1 to 100 micron depths and widths, the method comprising the steps of: coating the tissue-facing surfaces with a layer of pure titanium; sterilizing the titanium coated implant; forming a thin layer of titanium oxide over the pure titanium layer as the free surface of the implant; and implanting the titanium coated implant into the host's soft tissue bed.
Claim 12
Independent Claim
105 words
A method of promoting tissue adhesion of a host's soft tissue bed to the tissue-facing surfaces of a soft tissue implant wherein the tissue-facing surfaces are formed of a polymeric material having a roughened surface texture, the roughness being hills and valleys in a range of 1 to 100 micron depths and widths, the method comprising the steps of: coating the tissue-facing surfaces with a layer of pure titanium; sterilizing the titanium coated implant; forming a thin layer of titanium oxide over the pure titanium layer as the free surface of the implant; and implanting the titanium coated implant into the host's soft tissue bed.
Claim 13
Dependent Claim
26 words
A method as in claim 8, wherein: said coating step comprises vapor deposition of pure titanium on the roughened tissue-facing surfaces of the soft tissue implant.
Claim 14
Independent Claim
81 words
A method of promoting tissue adhesion of a host's soft tissue bed to a soft tissue implant having tissue-facing surfaces formed of a polymeric fabric, the method comprising the steps of: coating the tissue-facing surfaces of the polymeric fabric with a layer of pure titanium; sterilizing the titanium coated implant; forming a thin layer of titanium oxide over the pure titanium layer as the free surface of the implant; and implanting the titanium coated implant into the host's soft tissue bed.
Claim 15
Independent Claim
81 words
A method of promoting tissue adhesion of a host's soft tissue bed to a soft tissue implant having tissue-facing surfaces formed of a polymeric fabric, the method comprising the steps of: coating the tissue-facing surfaces of the polymeric fabric with a layer of pure titanium; sterilizing the titanium coated implant; forming a thin layer of titanium oxide over the pure titanium layer as the free surface of the implant; and implanting the titanium coated implant into the host's soft tissue bed.
Claim 16
Dependent Claim
20 words
A method as in claim 10, wherein: said coating step comprises vapor deposition of pure titanium on the polymeric fabric.
Claim 17
Independent Claim
194 words
A method of promoting tissue adhesion of a host's soft tissue bed to the tissue-facing surfaces of a strip of polyethylene terephthalate velour, the method comprising the steps of: cleaning the strip with a low-residue detergent and rinsing same with fresh distilled water; refluxing the strip in distilled water at a temperature of less than 30° C. for more than one hour; drying the strip in a room-temperature desiccator for more than one day; degassing, sterilizing, packaging and storing the strip in a dust-free environment; removing the strip from the packaging and mounting the strip in a vacuum evaporator at an approximate angle of incidence of 90° from the source of the vacuum evaporator, said source comprising a pure titanium metal evaporant; evacuating the vacuum evaporator to a vacuum of about 2 ×10 -5 Torr; resistance heating the titanium evaporant until the strip is coated with a layer of pure titanium on the order of 1 micron thick; resterilizing the titanium coated strip; forming a thin layer of titanium oxide over the pure titanium layer as the free surface of the implant; and implanting the titanium coated strip into the host's soft tissue bed.
Claim 18
Independent Claim
194 words
A method of promoting tissue adhesion of a host's soft tissue bed to the tissue-facing surfaces of a strip of polyethylene terephthalate velour, the method comprising the steps of: cleaning the strip with a low-residue detergent and rinsing same with fresh distilled water; refluxing the strip in distilled water at a temperature of less than 30° C. for more than one hour; drying the strip in a room-temperature desiccator for more than one day; degassing, sterilizing, packaging and storing the strip in a dust-free environment; removing the strip from the packaging and mounting the strip in a vacuum evaporator at an approximate angle of incidence of 90° from the source of the vacuum evaporator, said source comprising a pure titanium metal evaporant; evacuating the vacuum evaporator to a vacuum of about 2 ×10 -5 Torr; resistance heating the titanium evaporant until the strip is coated with a layer of pure titanium on the order of 1 micron thick; resterilizing the titanium coated strip; forming a thin layer of titanium oxide over the pure titanium layer as the free surface of the implant; and implanting the titanium coated strip into the host's soft tissue bed.
References Cited (Backward Citations)
US3557795A
Cited
US3677795A
Cited
US3952334A
Cited
US4374669A
Cited
US4149277A
Cited
US4272855A
Cited
US4531916A
Cited
US4588667A
Cited
WO1986002804A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-07-10 | 1993-01-09 | 1993-07-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-07-10 | 1997-01-09 | 1997-07-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-07-10 | 2001-01-09 | 2001-07-11 | $7700.00 | Window Closed / Lapsed |