US5454886A
Expired / Lapsed
US
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Process of activating anti-microbial materials
Assignee: Nucryst Pharmaceuticals Corp Canada
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Filing: 1993-11-18
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Granted: 1995-10-03
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Expires: 2013-11-18
Abstract
Abstract Anti-microbial coatings and powders and method of forming same on medical devices are provided. The coatings are formed by depositing an anti-microbial biocompatible metal by vapour deposition techniques to produce atomic disorder in the coating such that a sustained release of metal ions sufficient to produce an anti-microbial effect is achieved. Preferred deposition conditions to achieve atomic disorder include a lower than normal substrate temperature, and one or more of a higher than normal working gas pressure and a lower than normal angle of incidence of coating flux. Anti-microbial powders formed by mechanical working to produce atomic disorder are also provided. The anti-microbial effect of the coatings or powders may be further activated or enhanced by irradiating with a low linear energy transfer form of radiation such as gamma radiation.
Inventors
- 👤 Robert E. Burrell
- 👤 Catherine L. McIntosh
- 👤 Larry R. Morris
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:14
CPC Classifications
C; C23; C23C; C23C14/00; C23C14/58; C23C14/5873; C23C14/588; A; A01; A01N; A01N59/00; A01N59/16; A01N59/26; A61; A61L; A61L17/00; A61L17/14; A61L17/145; A61L29/00; A61L29/08; A61L29/10; A61L29/106; C23C14/0021; C23C14/0036; C23C14/02; C23C14/024; C23C14/025; C23C14/06; C23C14/0688; C23C14/08; C23C14/086; C23C14/14; C23C14/16; A61B; A61B18/00; A61B2018/00053; A61B2018/00107; A61B2018/00119; Y; Y10; Y10S; Y10S623/00; Y10S623/924
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
106 words
A method of forming an anti-microbial material containing one or more anti-microbial metals, said method comprising: creating atomic disorder in a material containing one or more anti-microbial metals under conditions which limit diffusion for retaining atomic disorder therein to provide sustained release of atoms, ions, molecules or clusters of at least one of the metals into an alcohol or water based electrolyte at an enhanced rate relative to the material in its normal ordered crystalline state; and irradiating the material with a low linear energy transfer form of radiation to release at least one anti-microbial metal at a concentration sufficient to provide a localized anti-microbial effect.
Claim 2
Independent Claim
106 words
A method of forming an anti-microbial material containing one or more anti-microbial metals, said method comprising: creating atomic disorder in a material containing one or more anti-microbial metals under conditions which limit diffusion for retaining atomic disorder therein to provide sustained release of atoms, ions, molecules or clusters of at least one of the metals into an alcohol or water based electrolyte at an enhanced rate relative to the material in its normal ordered crystalline state; and irradiating the material with a low linear energy transfer form of radiation to release at least one anti-microbial metal at a concentration sufficient to provide a localized anti-microbial effect.
Claim 3
Dependent Claim
34 words
The method as set forth in claim 1, wherein the anti-microbial metal is selected from the group consisting of Ag, Au, Pt, Pd, Ir, Sn, Cu, Sb, Bi, Zn, alloys thereof, and compounds thereof.
Claim 4
Dependent Claim
39 words
The method as set forth in claim 2, wherein the material is a powder or foil of one or more of the anti-microbial metals, and wherein the atomic disorder is formed by cold working of the powder or foil.
Claim 5
Dependent Claim
37 words
The method as set forth in claim 2, wherein the material is formed as a coating on a substrate by vapour deposition under conditions which limit diffusion during deposition and which limit annealing or recrystallization following deposition.
Claim 6
Dependent Claim
15 words
The method as set forth in claim 3, wherein the material is a nanocrystalline powder.
Claim 7
Dependent Claim
22 words
The method as set forth in claim 4, wherein the material is formed by vacuum evaporation, sputtering, magnetron sputtering or ion plating.
Claim 8
Dependent Claim
56 words
The method as set forth in claim 4, wherein the coating is formed by magnetron sputtering at conditions such that the ratio of the temperature of the surface being coated to the melting point of the anti-microbial material being deposited is less than about 0.5, and the working gas pressure is greater than about 10 mT.
Claim 9
Dependent Claim
124 words
The method as set forth in claim 6, wherein the anti-microbial material is a composite coating formed by co-, sequentially or reactively depositing an anti-microbial metal in a matrix with atoms or molecules of a different material to create atomic disorder in the matrix, said different material being deposited as one or more members selected from the group consisting of oxygen, nitrogen, hydrogen, boron, sulphur or halogen absorbed or trapped in the matrix from the atmosphere of the vapour deposition; an oxide, nitride, carbide, boride, halide, sulphide or hydride of an anti-microbial metal; and an oxide, nitride, carbide, boride, halide, sulphide or hydride of an inert biocompatible metal selected from the group consisting of Ta, Ti, Nb, V, Hf, Zn, Mo, Si, and Al.
Claim 10
Dependent Claim
44 words
The method as set forth in claim 8, wherein the anti-microbial metal is silver and said different material is one or both of silver oxide and atoms or molecules containing oxygen trapped or absorbed in the matrix from the atmosphere of the vapour deposition.
Claim 11
Dependent Claim
56 words
The method as set forth in claim 8, wherein the coating is formed by magnetron sputtering at conditions such that the ratio of the temperature of the surface being coated to the melting point of the anti-microbial material being deposited is less than about 0.5, and the working gas pressure is greater than about 10 mT.
Claim 12
Dependent Claim
56 words
The method as set forth in claim 9, wherein the coating is formed by magnetron sputtering at conditions such that the ratio of the temperature of the surface being coated to the melting point of the anti-microbial material being deposited is less than about 0.5, and the working gas pressure is greater than about 10 mT.
Claim 13
Dependent Claim
23 words
The process as set forth in claim 1, 3 or 6, wherein the form of radiation is selected from gamma, beta and x-rays.
Claim 14
Dependent Claim
29 words
The process as set forth in claim 1, 3 or 6, wherein the source of radiation is gamma radiation, used at a dose of greater than about 1 Mrad.
Claim 15
Dependent Claim
25 words
The process as set forth in claim 1, 3 or 6, wherein the anti-microbial material being irradiated is oriented substantially perpendicular to the incoming radiation.
Claim 16
Dependent Claim
23 words
The process as set forth in claim 1, 3 or 6, wherein the material is placed adjacent to a dielectric material during irradiation.
Claim 17
Dependent Claim
22 words
The process as set forth in claim 1, 3 or 6, wherein the material is sandwiched between silicon oxide surfaces during irradiation.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-10-02 | 1999-04-03 | 1999-10-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-10-02 | 2003-04-03 | 2003-10-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-10-02 | 2007-04-03 | 2007-10-03 | $7700.00 | Window Closed / Lapsed |