US5749922A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Biodegradable polymeric endoluminal sealing process, apparatus and polymeric products for use therein
Assignee: Endoluminal Therapeutics Inc
•
Filing: 1995-06-07
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Granted: 1998-05-12
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Expires: 2015-06-07
Abstract
Abstract A novel process for paving or sealing the interior surface of a tissue lumen by entering the interior of the tissue lumen and applying a polymer to the interior surface of the tissue lumen. This is accomplished using a catheter which delivers the polymer to the tissue lumen and causes it to conform to the interior surface of lumen. The polymer can be delivered to the lumen as a monomer or prepolymer solution, or as an at least partially preformed layer on an expansile member.
Inventors
- 👤 Marvin J. Slepian
- 👤 Anton Schindler
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:51
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/95; A61F2/958; A61F2/02; A61F2/04; A61F2/06; A61F2/062; A61F2/82; A61F2/86; A61F2/88; A61L; A61L24/00; A61L24/001; A61L24/0015; A61L24/0031; A61L24/0042; A61L24/04; A61L24/046; A61L24/06; A61L27/00; A61L27/14; A61L27/16; A61L27/18; A61L27/28; A61L27/34; A61L27/50; A61L27/54; A61L27/58; A61L29/00; A61L29/08; A61L29/085; A61L31/00; A61L31/08; A61L31/10; A61M; A61M25/00; A61M25/0043; A61M25/10; A61M25/1011; A61M37/00; F; F16; F16B; F16B39/00; F16B39/02; F16B39/04; F16B39/06; A61F2/94; A61F2/945; A61F2/30; A61F2002/30001; A61F2002/30003; A61F2002/3006; A61F2002/30062; A61F2002/30316; A61F2002/30535; A61F2002/30581; A61F2002/30583; A61F2002/30667; A61F2002/30677; A61F2210/00; A61F2210/0004; A61F2210/0085; A61F2250/00; A61F2250/0058; A61F2250/0067; A61L2300/00; A61L2300/40; A61L2300/412; A61L2300/60; A61L2300/602; A61L2300/604; A61L2300/64; A61M25/1002; F16B37/00; F16B37/12; F16B37/122; Y; Y10; Y10S; Y10S623/00; Y10S623/92; Y10S623/921; Y10T; Y10T29/00; Y10T29/49; Y10T29/49826; Y10T29/49906
Claims Analysis
Total Claims: 33
Claim 1
Independent Claim
80 words
A substantially cylindrical polymeric article having a radius and axial length constructed and arranged for paving or stabilizing an irregularly contoured tissue surface of a lumen or hollow organ of a mammal, the article being partially preformed and having a surface moldable in vivo, under conditions tolerable by the tissue surface, into intimate and conforming contact with the tissue surface by way of expansion of the radius of the article with essentially no change in axial length of the article.
Claim 2
Dependent Claim
80 words
A substantially cylindrical polymeric article having a radius and axial length constructed and arranged for paving or stabilizing an irregularly contoured tissue surface of a lumen or hollow organ of a mammal, the article being partially preformed and having a surface moldable in vivo, under conditions tolerable by the tissue surface, into intimate and conforming contact with the tissue surface by way of expansion of the radius of the article with essentially no change in axial length of the article.
Claim 3
Dependent Claim
16 words
A polymeric article as in claim 1, wherein the article is made of a biodegradable polymer.
Claim 4
Dependent Claim
15 words
A polymeric article as in claim 1, the article including at least one therapeutic agent.
Claim 5
Dependent Claim
13 words
A polymeric article as in claim 1, the article including a living cell.
Claim 6
Dependent Claim
14 words
A polymeric article as in claim 1, wherein the article has a multi-layered structure.
Claim 7
Dependent Claim
31 words
A polymeric article as in claim 5, wherein the entire article is moldable in vivo, under conditions tolerable by the tissue surface, into intimate and conforming contact with the tissue surface.
Claim 8
Dependent Claim
12 words
A polymeric article as in claim 1, further comprising a biocompatible coating.
Claim 9
Dependent Claim
47 words
A polymeric article as in claim 1, wherein the article is made of a polymer selected from the group consisting of polymers of caprolactones, anhydrides, polylactides, glycolides, oxyalkylenes, carboxylic acids, urethanes, esters, amides, acrylonitriles, phosphazines, ethylene, vinyl fluoride, ethylene vinyl acetate, and blends and copolymeric combinations thereof.
Claim 10
Dependent Claim
40 words
A polymeric article as in claim 1, wherein the article is made of a polymer selected from the group consisting of polymers of glycolic acid, glycolide, lactic acid, lactide, beta-hydroxybutyric acid, delta-valerolactone, p-dioxanone, epsilon-caprolactone, and blends and copolymeric combinations thereof.
Claim 11
Dependent Claim
20 words
A polymeric article as in claim 1, wherein the article is made of a polymer of at least one anhydride.
Claim 12
Dependent Claim
16 words
A polymeric article as in claim 10, wherein the polymer subunits are at least partially crosslinked.
Claim 13
Dependent Claim
47 words
A polymeric article as in claim 1, wherein the surface that is moldable in vivo into intimate and conforming contact with the tissue surface is non-fluent at body temperature, becomes fluent at an altered temperature different from body temperature, and becomes non-fluent on returning to body temperature.
Claim 14
Dependent Claim
18 words
A polymeric article as in claim 12, wherein the altered temperature is a temperature higher than body temperature.
Claim 15
Dependent Claim
33 words
A polymeric article as in claim 1, wherein the article is non-fluent at body temperature, becomes fluent at an altered temperature different from body temperature, and becomes non-fluent on returning to body temperature.
Claim 16
Dependent Claim
18 words
A polymeric article as in claim 14, wherein the altered temperature is a temperature higher than body temperature.
Claim 17
Dependent Claim
23 words
A polymeric article as in claim 1, wherein the article is constructed and adapted for application to the tissue surface with a catheter.
Claim 18
Dependent Claim
25 words
A polymeric article as in claim 16, wherein the article is adapted for application to the tissue surface with an expandable region of a catheter.
Claim 19
Dependent Claim
37 words
A polymer article as in claim 17, wherein the article is an at least partially preformed paving, coating or cylindrical article having radial mechanical strength adequate to provide structural stability to a hollow organ or tissue lumen.
Claim 20
Dependent Claim
26 words
A polymer article as in claim 18, wherein the article is a partially preformed essentially cylindrical article having radial mechanical strength adequate to provide structural stability.
Claim 21
Dependent Claim
13 words
An article as in claim 18, wherein the article is a cylindrical sleeve.
Claim 22
Dependent Claim
21 words
A polymeric article as in claim 1, constructed and arranged for paving or stabilizing an interior surface of a blood vessel.
Claim 23
Dependent Claim
20 words
A polymeric article as in claim 21, constructed and arranged for paving or stabilizing an interior surface of an artery.
Claim 24
Dependent Claim
65 words
A polymeric article constructed and arranged for paving or stabilizing an irregularly contoured tissue surface of a lumen or hollow organ of a mammal, the article being partially preformed to approximately match the shape of the surface of the lumen or organ and having a surface moldable in vivo, under conditions tolerable by the tissue surface, into intimate and conforming contact with the tissue surface.
Claim 25
Dependent Claim
65 words
A polymeric article constructed and arranged for paving or stabilizing an irregularly contoured tissue surface of a lumen or hollow organ of a mammal, the article being partially preformed to approximately match the shape of the surface of the lumen or organ and having a surface moldable in vivo, under conditions tolerable by the tissue surface, into intimate and conforming contact with the tissue surface.
Claim 26
Dependent Claim
31 words
A polymeric article as in claim 1, wherein the entire article is moldable in vivo, under conditions tolerable by the tissue surface, into intimate and conforming contact with the tissue surface.
Claim 27
Dependent Claim
78 words
A polymeric article constructed and arranged for paving or stabilizing an irregularly contoured tissue surface of a lumen or hollow organ of a mammal and remaining at the surface for a therapeutically effective period of time, the article having a surface that matches an interior tissue surface of a hollow organ or tissue lumen, the surface formed by molding the article into intimate and conforming contact with the tissue surface in vivo under conditions tolerable by the tissue.
Claim 28
Dependent Claim
78 words
A polymeric article constructed and arranged for paving or stabilizing an irregularly contoured tissue surface of a lumen or hollow organ of a mammal and remaining at the surface for a therapeutically effective period of time, the article having a surface that matches an interior tissue surface of a hollow organ or tissue lumen, the surface formed by molding the article into intimate and conforming contact with the tissue surface in vivo under conditions tolerable by the tissue.
Claim 29
Dependent Claim
20 words
A polymeric article as in claim 25, wherein the article includes a fluid pathway adapted for passage of physiological fluid.
Claim 30
Dependent Claim
13 words
A polymeric article as in claim 26, wherein the article is substantially cylindrical.
Claim 31
Dependent Claim
31 words
A polymeric article as in claim 25, wherein the entire article is moldable in vivo, under conditions tolerable by the tissue surface, into intimate and conforming contact with the tissue surface.
Claim 32
Dependent Claim
53 words
A non-filamentary polymeric article constructed and arranged for paving or stabilizing an irregularly contoured tissue surface of a lumen or hollow organ of a mammal, the article being partially preformed and having a surface moldable in vivo, under conditions tolerable by the tissue surface, into intimate and conforming contact with the tissue surface.
Claim 33
Dependent Claim
53 words
A non-filamentary polymeric article constructed and arranged for paving or stabilizing an irregularly contoured tissue surface of a lumen or hollow organ of a mammal, the article being partially preformed and having a surface moldable in vivo, under conditions tolerable by the tissue surface, into intimate and conforming contact with the tissue surface.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-05-11 | 2001-11-10 | 2002-05-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-05-11 | 2005-11-10 | 2006-05-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-05-11 | 2009-11-10 | 2010-05-12 | $7700.00 | Window Closed / Lapsed |