US4443430A — Synthetic absorbable hemostatic agent

Claim 1

Independent Claim 111 words

A synthetic absorbable hemostatic agent for use in the control of osseous hemorrhage, comprising a copolymer of lactide and glycolide containing from about 30% to 70% lactide on a molar basis, having a molecular weight such that it is workable and softenable by hand to bring about a putty-like consistency at room temperature, the agent having a tackiness sufficient for it to adhere readily to a bloody bone surface and yet being able to be manipulated without crumbling or sticking to the surgeon's gloves, said copolymer having an inherent viscosity in hexafluoroisopropanol at a concentration of 0.1 g/dl and at a temperature of 25° C. of between about 0.03 and 0.1.

Claim 2

Dependent Claim 111 words

A synthetic absorbable hemostatic agent for use in the control of osseous hemorrhage, comprising a copolymer of lactide and glycolide containing from about 30% to 70% lactide on a molar basis, having a molecular weight such that it is workable and softenable by hand to bring about a putty-like consistency at room temperature, the agent having a tackiness sufficient for it to adhere readily to a bloody bone surface and yet being able to be manipulated without crumbling or sticking to the surgeon's gloves, said copolymer having an inherent viscosity in hexafluoroisopropanol at a concentration of 0.1 g/dl and at a temperature of 25° C. of between about 0.03 and 0.1.

Claim 3

Dependent Claim 112 words

A synthetic absorbable hemostatic agent for use in the control of osseous hemorrhage, comprising a copolymer of lactide and glycolide containing from about 60% to 70% lactide on a molar basis and having a molecular weight such that it is workable and softenable by hand to bring about a putty-like consistency at room temperature, the agent having a tackiness sufficient for it to adhere readily to a bloody bone surface and yet being able to be manipulated without crumbling or sticking to the surgeon's gloves, said copolymer having an inherent viscosity in hexafluoroisopropanol at a concentration of 0.1 g/dl and at a temperature of 25° C. of between about 0.03 and 0.1.

Claim 4

Dependent Claim 112 words

A synthetic absorbable hemostatic agent for use in the control of osseous hemorrhage, comprising a copolymer of lactide and glycolide containing from about 60% to 70% lactide on a molar basis and having a molecular weight such that it is workable and softenable by hand to bring about a putty-like consistency at room temperature, the agent having a tackiness sufficient for it to adhere readily to a bloody bone surface and yet being able to be manipulated without crumbling or sticking to the surgeon's gloves, said copolymer having an inherent viscosity in hexafluoroisopropanol at a concentration of 0.1 g/dl and at a temperature of 25° C. of between about 0.03 and 0.1.

Claim 5

Dependent Claim 17 words

The agent of claim 2 in which the lactide/glycolide ratio is about 65/35 on a molar basis.

Claim 6

Dependent Claim 26 words

The agent of claim 2 which includes a biocompatible base which is a non-chemically reacting material capable of forming a solution or gel with said agent.

Claim 7

Dependent Claim 26 words

The agent of claim 4 in which the biocompatible base is selected from one or more of the group comprising: calcium stearate, glyceryl monostearate and water.

Claim 8

Dependent Claim 24 words

The agent of claim 5, which includes from 1% to 5% by weight of calcium stearate, based on the total weight of the composition.

Claim 9

Dependent Claim 24 words

The agent of claim 5, which includes from 5% to 30% by weight of glyceryl monostearate based upon the total weight of the composition.

Claim 10

Dependent Claim 23 words

The agent of claim 5 which includes from 1% to 25% by weight of water based on the total weight of the composition.

Claim 11

Dependent Claim 21 words

The agent of claim 2 comprising about 65% lactide, the molecular weight of said agent being between about 2000 and 2500.

Claim 12

Dependent Claim 27 words

The agent of claim 9 in which the inherent viscosity inhexafluoroisopropanol at a concentration of 0.1 g/dl and at a temperature of 25° C. is about 0.05.

Claim 13

Dependent Claim 38 words

A copolymer, comprising about 65% lactide and 35% glycolide on a molar basis, having an inherent viscosity in hexafluoroisopropanol at a concentration of 0.1 g/dl and at a temperature of 25° C. of between about 0.03 and 0.1.

Claim 14

Dependent Claim 38 words

A copolymer, comprising about 65% lactide and 35% glycolide on a molar basis, having an inherent viscosity in hexafluoroisopropanol at a concentration of 0.1 g/dl and at a temperature of 25° C. of between about 0.03 and 0.1.

Claim 15

Dependent Claim 28 words

The copolymer of claim 11 in which the inherent viscosity in hexafluoroisopropanol at a concentration of 0.1 g/dl and at a temperature of 25° C. is about 0.05.

Claim 16

Dependent Claim 117 words

An absorbable hemostatic composition for use in the control of osseous hemorrhage comprising by weight: 85 to 95% of a 65/35 molar lactide/glycolide copolymer in which the inherent viscosity in hexafluoroisopropanol at a concentration of 0.1 g/dl and at a temperature of 25° C. ranges between 0.03 and 0.1, from 1 to 5% calcium stearate and the remainder, if any, being glyceryl monostearate, said composition having a molecular weight such that it is workable and softenable by hand to bring about a putty-like consistency at room temperature, and having a tackiness sufficient for it to adhere readily to a bloody bone surface and yet being able to be manipulated without crumbling or sticking to the surgeon's gloves.

Claim 17

Dependent Claim 117 words

An absorbable hemostatic composition for use in the control of osseous hemorrhage comprising by weight: 85 to 95% of a 65/35 molar lactide/glycolide copolymer in which the inherent viscosity in hexafluoroisopropanol at a concentration of 0.1 g/dl and at a temperature of 25° C. ranges between 0.03 and 0.1, from 1 to 5% calcium stearate and the remainder, if any, being glyceryl monostearate, said composition having a molecular weight such that it is workable and softenable by hand to bring about a putty-like consistency at room temperature, and having a tackiness sufficient for it to adhere readily to a bloody bone surface and yet being able to be manipulated without crumbling or sticking to the surgeon's gloves.

Claim 18

Dependent Claim 115 words

A process for the control of bleeding from cut bone surfaces, which comprises applying to the cut bone surface, a copolymer of lactide and glycolide containing from 30% to 70% lactide on a molar basis, having a molecular weight such that it is workable and softenable by hand to bring about a putty-like consistency at room temperature, the agent having a tackiness sufficient for it to adhere readily to a bloody bone surface and yet being able to be manipulated without crumbling or sticking to the surgeon's gloves, said copolymer having an inherent viscosity in hexafluoroisopropanol at a concentration of 0.1 g/dl and at a temperature of 25° C. of between about 0.03 and 0.1.

Claim 19

Dependent Claim 115 words

A process for the control of bleeding from cut bone surfaces, which comprises applying to the cut bone surface, a copolymer of lactide and glycolide containing from 30% to 70% lactide on a molar basis, having a molecular weight such that it is workable and softenable by hand to bring about a putty-like consistency at room temperature, the agent having a tackiness sufficient for it to adhere readily to a bloody bone surface and yet being able to be manipulated without crumbling or sticking to the surgeon's gloves, said copolymer having an inherent viscosity in hexafluoroisopropanol at a concentration of 0.1 g/dl and at a temperature of 25° C. of between about 0.03 and 0.1.

Claim 20

Dependent Claim 116 words

A process for the control of bleeding from cut bone surfaces, which comprises applying to the cut bone surface, a copolymer of lactide and glycolide containing from 60% to 70% lactide on a molar basis and having a molecular weight such that it is workable and softenable by hand to bring about a putty-like consistency at room temperature, the copolymer having a tackiness sufficient for it to adhere readily to a bloody bone surface and yet being able to be manipulated without crumbling or sticking to the surgeon's gloves, said copolymer having an inherent viscosity in hexafluoroisopropanol at a concentration of 0.1 g/dl and at a temperature of 25° C. of between about 0.3 and 0.1.

Claim 21

Dependent Claim 116 words

A process for the control of bleeding from cut bone surfaces, which comprises applying to the cut bone surface, a copolymer of lactide and glycolide containing from 60% to 70% lactide on a molar basis and having a molecular weight such that it is workable and softenable by hand to bring about a putty-like consistency at room temperature, the copolymer having a tackiness sufficient for it to adhere readily to a bloody bone surface and yet being able to be manipulated without crumbling or sticking to the surgeon's gloves, said copolymer having an inherent viscosity in hexafluoroisopropanol at a concentration of 0.1 g/dl and at a temperature of 25° C. of between about 0.3 and 0.1.

Claim 22

Dependent Claim 25 words

The process of claim 15 in which the copolymer comprises about 65% lactide, the molecular weight of the copolymer being between about 2000 and 2500.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1987-04-17	1987-10-17	1988-04-17	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	1991-04-17	1991-10-17	1992-04-17	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	1995-04-17	1995-10-17	1996-04-17	$7700.00	Window Closed / Lapsed

Synthetic absorbable hemostatic agent

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