Plastic wound bandage

Claim 2

A process of treating a wound comprising applying to the surface of the wound a settable, non-toxic paste consisting essentially of a particulate, hydrophilic, water-swellable polymer and an inert, non-toxic water-miscible organic liquid having a boiling point above about 120° C. capable of forming a paste therewith, said organic liquid being polyethylene glycol or oxyethyleneoxypropylene glycol of 200-2000 molecular weight and said polymer being a polymer of hydroxy(C 2 -C 4 -alkyl) methacrylate, hydroxy(C 2 -C 4 alkyl) acrylate, hydroxy(C 2 -C 4 alkoxyC 2 -C 4 alkyl)methacrylate, hydroxy(C 2 -C 4 alkoxyC 2 -C 4 alkyl)acrylate, alkoxy(C 2 -C 4 alkoxyC 2 -C 4 alkyl) methacrylate, alkoxy(C 2 -C 4 alkoxyC 2 -C 4 alkyl) acrylate, N-(C 1 -C 4 alkyl)acrylamide, N-(C 1 -C 4 alkyl)methacrylamide, N,N-di(C 1 -C 4 -alkyl)acrylamide, N,N-(di(C 1 -C 4 alkyl)methacrylamide, vicinal-epoxy(C 1 -C 4 alkyl methacrylate, or vicinal-epoxy(C 1 -C 4 alkyl)acrylate, said paste having a setting time of up to about one hour and a working time sufficient to apply the paste to the said wound surface, the polymer of said paste in set condition being water-insoluble, the ratio of polymer to organic liquid in the paste being from above about 0.8:1 to about 1.4:1 by weight, whereby there is formed a non-tacky, homogeneous, occlusive film on the surface of the wound.

Claim 3

The process of claim 1 wherein the settable paste consists of the stated materials and a germicide, fungicide, antibiotic or analgesic.

Claim 4

The process of claim 1 wherein said paste is applied to a burned tissue surface.

Claim 5

The process of claim 1 wherein said paste has a working time less than about 45-50 minutes.

Claim 6

The process of claim 1 wherein said polymer is at least slightly crosslinked and has a molecular weight at least about 50,000.

Claim 7

The process of claim 5 wherein said organic liquid is characterized by a plurality of --CH 2 CH 2 O-- units and a boiling point above about 200° C.

Claim 8

The process of claim 6 wherein said organic liquid is polyethylene glycol of 200-1600 molecular weight and said polymer is a polymer of hydroxy(C 2 -C 4 -alkyl) methacrylate, hydroxy(C 2 -C 4 alkyl) acrylate, hydroxy(C 2 -C 4 alkoxyC 2 -C 4 alkyl)methacrylate, hydroxy(C 2 -C 4 alkoxy-C 2 -C 4 alkyl)acrylate, alkoxy(C 2 -C 4 alkyl)methacrylate, alkoxy(C 2 -C 4 alkoxyC 2 -C 4 alkyl) acrylate, N-(C 1 -C 4 alkyl)acrylamide, N-(C 1 -C 4 alkyl)methacrylamide, N,N-di(C 1 -C 4 alkyl)acrylamide, N,N-(di(C 1 -C 4 alkyl)methacrylamide, vicinal-epoxy(C 1 -C 4 alkyl methacrylate, or vicinal-epoxy(C 1 -C 4 alkyl(acrylate.

Claim 9

The process of claim 7 wherein the polyethylene glycol has a molecular weight of 400-800.

Claim 10

The process of claim 7 wherein said polymer is characterized by at least 50 mol percent of the following recurring unit ##STR3## wherein R is hydrogen or methyl, wherein R 1 is C 2 -C 4 alkylene, and wherein R 2 is hydrogen, C 1 -C 4 alkyl or C 1 -C 4 alkoxyC 1 -C 4 alkyl.

Claim 11

The process of claim 9 wherein said polymer is characterized by at least 80 mol percent and wherein R is methyl and wherein R 1 is C 2 -C 4 alkylene.

Claim 12

The process of claim 9 wherein said organic liquid is polyethylene glycol of 200-1000 molecular weight and wherein the polymer contains recurring 2-hydroxyethyl methacrylate units.

Claim 13

The process of claim 11 wherein said polymer is a crosslinked 2-hydroxyethyl methacrylate polymer.

Claim 14

The process of claim 12 wherein the ratio of polymer to organic liquid is from about 0.85:1 to below about 1.4:1 by weight.

Claim 15

The process of claim 13 wherein the ratio of polymer to organic liquid is from about 0.85:1 to about 1.25:1 by weight.

Claim 16

The process of claim 14 wherein said paste is applied to a burned tissue surface as a thin film and wherein the ratio of polymer to organic liquid is from approximately 1:1 to 1.2:1 by weight.

Claim 17

The process of claim 15 wherein the burned tissue surface is the surface of a second, third, or fourth degree burn.

Claim 18

The process of claim 13 wherein said paste contains a medicinally active ingredient therein.

Claim 19

A settable, non-toxic paste suitable for forming a homogeneous, non-tacky, non-toxic, occlusive film on the surface of a wound (1) said paste consisting essentially of (a) particulate water-insoluble, water-swellable, hydrophilic polymer and (b) an inert, water-miscible, organic liquid having a boiling point above about 120° C. and capable of forming a paste therewith, said organic liquid being polyethylene glycol or oxyethyleneoxypropylene glycol of 200-2000 molecular weight and said polymer being a polymer of hydroxy(C 2 -C 4 -alkyl) methacrylate, hydroxy(C 2 -C 4 alkyl) acrylate, hydroxy(C 2 -C 4 alkoxyC 2 -C 4 -alkyl)methacrylate, hydroxy(C 2 -C 4 alkoxyC 2 -C 4 alkyl)acrylate, alkoxy(C 2 -C 4 alkoxyC 2 -C 4 alkoxyC 2 -C 4 alkyl) methacrylate, alkoxy(C 2 -C 4 alkoxyC 2 -C 4 alkyl) acrylate, N-(C 1 -C 4 alkyl)acrylamide, N-(C 1 -C 4 alkyl)methacrylamide, N,N-di(C 1 -C 4 -alkyl)acrylamide, N,N-(di(C 1 -C 4 alkyl)methacrylamide, vicinal-epoxy(C 1 -C 4 alkyl methacrylate, or vicinal-epoxy(C 1 -C 4 alkyl)acrylate; (2) said polymer being present in an amount sufficient to impart to said paste a setting time period no greater than about one hour and a working time sufficient to apply the paste to the wound surface; (3) the hydrophilic polymer of said paste in set condition remaining water-insoluble, the ratio of polymer to organic liquid in the paste being from above about 0.8:1 to about 1.4:1 by weight.

Claim 20

A settable, non-toxic paste suitable for forming a homogeneous, non-tacky, non-toxic, occlusive film on the surface of a wound (1) said paste consisting essentially of (a) particulate water-insoluble, water-swellable, hydrophilic polymer and (b) an inert, water-miscible, organic liquid having a boiling point above about 120° C. and capable of forming a paste therewith, said organic liquid being polyethylene glycol or oxyethyleneoxypropylene glycol of 200-2000 molecular weight and said polymer being a polymer of hydroxy(C 2 -C 4 -alkyl) methacrylate, hydroxy(C 2 -C 4 alkyl) acrylate, hydroxy(C 2 -C 4 alkoxyC 2 -C 4 -alkyl)methacrylate, hydroxy(C 2 -C 4 alkoxyC 2 -C 4 alkyl)acrylate, alkoxy(C 2 -C 4 alkoxyC 2 -C 4 alkoxyC 2 -C 4 alkyl) methacrylate, alkoxy(C 2 -C 4 alkoxyC 2 -C 4 alkyl) acrylate, N-(C 1 -C 4 alkyl)acrylamide, N-(C 1 -C 4 alkyl)methacrylamide, N,N-di(C 1 -C 4 -alkyl)acrylamide, N,N-(di(C 1 -C 4 alkyl)methacrylamide, vicinal-epoxy(C 1 -C 4 alkyl methacrylate, or vicinal-epoxy(C 1 -C 4 alkyl)acrylate; (2) said polymer being present in an amount sufficient to impart to said paste a setting time period no greater than about one hour and a working time sufficient to apply the paste to the wound surface; (3) the hydrophilic polymer of said paste in set condition remaining water-insoluble, the ratio of polymer to organic liquid in the paste being from above about 0.8:1 to about 1.4:1 by weight.

Claim 21

The settable paste of claim 18 wherein said polymer is at least slightly crosslinked and has a molecular weight at least about 50,000.

Claim 22

The settable paste of claim 19 wherein said organic liquid is characterized by a plurality of --CH 2 CH 2 O units and a boiling point above about 200° C.

Claim 23

The settable paste of claim 20 wherein said organic liquid is polyethylene glycol of 200-1600 molecular weight and said polymer is a polymer of hydroxy(C 2 -C 4 -alkyl) methacrylate, hydroxy(C 2 -C 4 alkyl) acrylate, hydroxy(C 2 -C 4 alkoxyC 2 -C 4 alkyl) methacrylate, hydroxy(C 2 -C 4 alkoxyC 2 -C 4 alkyl) acrylate, alkoxy(C 2 -C 4 alkoxyC 2 -C 4 alkyl) methacrylate, alkoxy(C 2 -C 4 alkoxyC 2 -C 4 alkyl) acrylate, N-(C 1 -C 4 alkyl)acrylamide, N-(C 1 -C 4 alkyl)methacrylamide, N,N-di(C 1 -C 4 alkyl)acrylamide, N,N-di(C 1 -C 4 alkyl)methacrylamide, vicinal-epoxy(C 1 -C 4 alkyl) methacrylate, or vicinal-epoxy(C 1 -C 4 alkyl) acrylate.

Claim 24

The settable paste of claim 21 wherein said polymer is characterized by at least 50 mol percent of the following recurring unit ##STR4## wherein R is hydrogen or methyl, wherein R 1 is C 2 -C 4 alkylene, and wherein R 2 is hydrogen, C 1 -C 4 alkyl or C 1 -C 4 alkoxy C 1 -C 4 alkyl.

Claim 25

The settable paste of claim 22 wherein said polymer is characterized by at least 80 mol percent and wherein R is methyl and wherein R 1 is C 2 -C 4 alkylene.

Claim 26

The settable paste of claim 23 which is suitable for forming a homogeneous, integral, non-tacky, non-toxic, occlusive film on a burned tissue surface wherein said organic liquid is polyethylene glycol of 200-1000 molecular weight and wherein the polymer contains recurring 2-hydroxyethyl methacrylate units.

Claim 27

The settable paste of claim 24 wherein said polymer is a crosslinked 2-hydroxyethyl polymer and wherein the ratio of polymer to organic liquid in the paste is from above about 0.8:1 to about 1.4:1 by weight.

Claim 28

The settable paste of claim 25 wherein the ratio of polymer to organic liquid is from about 0.85:1 to below about 1.4:1 by weight.

Claim 29

The settable paste of claim 26 wherein the ratio of polymer to organic liquid is from about 0.85:1 to about 1.25:1 by weight.

Claim 30

The settable paste of claim 26 wherein said paste contains a medicinally active ingredient therein.

Claim 31

The settable paste of claim 27 wherein the molecular weight of the polyethylene glycol is 400-800.

Claim 32

The settable paste of claim 28 wherein the medicinally active ingredient is a germicide, fungicide, antibiotic or analgesic.

Claim 33

The settable paste of claim 30 wherein the medicinally active ingredient is an antibiotic.

Claim 34

The settable paste of claim 30 wherein the medicinally active ingredient is a germicide.

Claim 35

The settable paste of claim 30 wherein the medicinally active ingredient is a fungicide.

Claim 36

The settable paste of claim 30 wherein the medicinally active ingredient is an analgesic.