US4292299A
Expired / Lapsed
US
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Slow-releasing medical preparation to be administered by adhering to a wet mucous surface
Assignee: Teijin Ltd
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Filing: 1980-07-07
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Granted: 1981-09-29
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Expires: 2000-07-07
Abstract
Abstract PCT No. PCT/JP79/00284 Sec. 371 Date Nov. 6, 1979 Sec. 102(e) Date July 7, 1980 PCT Filed July 7, 1980 PCT Pub. No. WO80/00916 PCT Pub. Date May 15, 1980 A medical preparation composed of an adhesive layer comprising polymers which have adhesiveness to a wet mucous surface and swellability upon moistening and a nonadhesive layer which has no adhesiveness to a wet mucous surface and is water soluble or water disintegrable, with at least one of the layers made to contain a medicament. The medical preparation is administered by adhering to a wet mucous surface of the mucous membrane and skin of men or animals, whereby exhibiting a property to release the medicament slowly extending over a long period of time to cure or prevent general or local diseases.
Inventors
- 👤 Yoshiki Suzuki
- 👤 Hiroshi Ikura
- 👤 Gentaro Yamashita
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 04:49
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/2072; A61K9/2086; A61K9/209; A61K9/0012; A61K9/0053; A61K9/006; A61K9/70
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
74 words
A slow-releasing medical preparation to be administered by adhering to a wet mucous surface comprising an adhesive layer composed of a polymer which has the adhesiveness to a wet mucous surface and a property to swell upon moistening and a nonadhesive, either water soluble or disintegrable, layer which has no adhesiveness to a wet mucous surface and at least either one of said adhesive layer and nonadhesive layer is made to contain a medicament.
Claim 2
Dependent Claim
74 words
A slow-releasing medical preparation to be administered by adhering to a wet mucous surface comprising an adhesive layer composed of a polymer which has the adhesiveness to a wet mucous surface and a property to swell upon moistening and a nonadhesive, either water soluble or disintegrable, layer which has no adhesiveness to a wet mucous surface and at least either one of said adhesive layer and nonadhesive layer is made to contain a medicament.
Claim 3
Dependent Claim
31 words
A slow-releasing medical preparation to be administered by adhering to a wet mucous surface according to claim 1, wherein a medicament is contained in the adhesive layer as an intimate mixture.
Claim 4
Dependent Claim
31 words
A slow-releasing medical preparation to be administered by adhering to a wet mucous surface according to claim 1, wherein the thickness of the adhesive layer is about 0.1 to 2.5 mm.
Claim 5
Dependent Claim
34 words
A slow-releasing medical preparation to be administered by adhering to a wet mucous surface according to claim 1, wherein the adhesive layer has the adhesiveness of about 40 g/cm 2 (adhesion area) or more.
Claim 6
Dependent Claim
31 words
A slow-releasing medical preparation to be administered by adhering to a wet mucous surface according to claim 1, wherein the preparation assumes the form of a tablet consisting of two layers.
Claim 7
Dependent Claim
82 words
A slow-releasing medical preparation to be administered by adhering to a wet mucous surface according to claim 1, wherein the polymer of the adhesive layer is at least one polymer selected from a group comprising acrylic acids or their pharmaceutically acceptable nontoxic salts, copolymers of acrylic acid or their pharmaceutically acceptable nontoxic salts, hydrophilic vinyl copolymers not copolymerized with acrylic acid as a main component, hydrophilic cellulose derivatives, polysaccharides or their derivatives and gelatine or collagen or their derivatives with improved swellability.
Claim 8
Dependent Claim
45 words
A slow-releasing medical preparation to be administered by adhering to a wet mucous surface according to claim 1, wherein the polymer of the adhesive layer is a mixture of cellulose ether and polyacrylic acid (or its salt) or copolymer of acrylic acid (or its salt).
Claim 9
Dependent Claim
29 words
A slow-releasing medical preparation to be administered by adhering to a wet mucous surface according to claim 1, wherein the nonadhesive layer comprises lactose or glucose or their mixture.
Claim 10
Dependent Claim
32 words
A slow-releasing medical preparation to be administered by adhering to a wet mucous surface according to claim 7, wherein the cellulose ether is methyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose or their mixture.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-09-28 | 1985-03-30 | 1985-09-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-09-28 | 1989-03-30 | 1989-09-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-09-28 | 1993-03-30 | 1993-09-29 | $7700.00 | Window Closed / Lapsed |