Patent US5584875A successfully refreshed from Google Patents.
US5584875A
Expired / Lapsed
US
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Method for making vascular grafts
Assignee: CR Bard Inc
•
Filing: 1994-04-13
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Granted: 1996-12-17
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Expires: 2014-04-13
Abstract
Abstract A method for forming vascular graft prostheses is described. In particular, the method relates to determining the carrying volume of a gelable material to fill the interstices of a fabric prosthesis, applying that carrying volume of gelable material to the prosthesis, and crosslinking the gelable material to form uniform gel-coated prostheses having low porosity.
Inventors
- 👤 Raymond C. Duhamel
- 👤 Stephen Eldridge
- 👤 Barbara Kelley
- 👤 Brendan McCrea
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:11
CPC Classifications
D; D06; D06M; D06M15/00; D06M15/01; D06M15/15; A; A61; A61F; A61F2/00; A61F2/02; A61F2/04; A61F2/06; A61L; A61L27/00; A61L27/40; A61L27/44; A61L27/48; D06M15/03; Y; Y10; Y10S; Y10S623/00; Y10S623/901; Y10S623/92; Y10S623/921
Claims Analysis
Total Claims: 46
Claim 1
Independent Claim
101 words
A method for fabricating a vascular prosthesis comprising the steps of: (a) providing a porous substrate comprising a textile tube having interstices, (b) providing a gelable material solution, (c) determining a carrying volume for the substrate of the gelable material solution, (d) loading the substrate with a volume of the gelable material solution equal to the carrying volume of the substrate, thereby filling the interstices of the substrate and providing a substrate containing gelable material, and (e) crosslinking the gelable material, thereby providing a substrate having a crosslinked gelled material contained within the interstices of the substrate and on its surface.
Claim 2
Independent Claim
101 words
A method for fabricating a vascular prosthesis comprising the steps of: (a) providing a porous substrate comprising a textile tube having interstices, (b) providing a gelable material solution, (c) determining a carrying volume for the substrate of the gelable material solution, (d) loading the substrate with a volume of the gelable material solution equal to the carrying volume of the substrate, thereby filling the interstices of the substrate and providing a substrate containing gelable material, and (e) crosslinking the gelable material, thereby providing a substrate having a crosslinked gelled material contained within the interstices of the substrate and on its surface.
Claim 3
Dependent Claim
13 words
The method of claim 1 wherein the textile tube comprises a polyester fabric.
Claim 4
Dependent Claim
12 words
The method of claim 2 wherein the textile is a woven fabric.
Claim 5
Dependent Claim
12 words
The method of claim 2 wherein the textile is a knitted fabric.
Claim 6
Dependent Claim
23 words
The method of claim 1 wherein the gelable material is a bioerodable polymer selected from the group consisting of polysaccharides, glycosaminoglycans and proteins.
Claim 7
Dependent Claim
21 words
The method of claim 1 wherein the gelable material is selected from the group consisting of albumin, gelatin, collagen and fibrinogen.
Claim 8
Dependent Claim
23 words
The method of claim 1 wherein the substrate is loaded by wicking the carrying volume of the gelable material solution into the substrate.
Claim 9
Dependent Claim
23 words
The method of claim 1 wherein the substrate is loaded by dripping the carrying volume of the gelable material solution onto the substrate.
Claim 10
Dependent Claim
23 words
The method of claim 1 wherein the substrate is loaded by spraying the carrying volume of the gelable material solution onto the substrate.
Claim 11
Dependent Claim
14 words
The method of claim 1 wherein the crosslinking is achieved using a crosslinking agent.
Claim 12
Dependent Claim
24 words
The method of claim 10 wherein the crosslinking agent comprises a material selected from the group consisting of formaldehydes, dialdehyde starches, carbodiimides and glutaraldehydes.
Claim 13
Dependent Claim
12 words
The method of claim 11 wherein the carbodiimide comprises 1-ethyl-3-(3-dimethyl-aminopropyl) carbodiimide hydrochloride.
Claim 14
Dependent Claim
20 words
The method of claim 10 wherein the crosslinking agent is mixed with the gelable material prior to the loading step.
Claim 15
Dependent Claim
27 words
The method of claim 4 wherein the substrate having the crosslinked gelled material includes between approximately 0.24 and 0.32 grams of gelled material per gram of fabric.
Claim 16
Independent Claim
108 words
A method for fabricating a vascular prosthesis comprising the steps of: (a) providing a porous substrate comprising a textile tube having interstices, (b) providing a gelable material solution, (c) determining a carrying volume for the substrate of the gelable material solution, (d) contacting the substrate with a surfactant prior to loading the substrate with the gelable material solution, (e) loading the substrate with a volume of the gelable material solution equal to the carrying volume of the substrate, thereby filling the interstices of the substrate and providing a substrate containing gelable material, (f) crosslinking the gelable material, and (g) contacting the substrate containing gelable material with a humectant.
Claim 17
Independent Claim
108 words
A method for fabricating a vascular prosthesis comprising the steps of: (a) providing a porous substrate comprising a textile tube having interstices, (b) providing a gelable material solution, (c) determining a carrying volume for the substrate of the gelable material solution, (d) contacting the substrate with a surfactant prior to loading the substrate with the gelable material solution, (e) loading the substrate with a volume of the gelable material solution equal to the carrying volume of the substrate, thereby filling the interstices of the substrate and providing a substrate containing gelable material, (f) crosslinking the gelable material, and (g) contacting the substrate containing gelable material with a humectant.
Claim 18
Dependent Claim
13 words
The method of claim 15 wherein the textile tube comprises a polyester fabric.
Claim 19
Dependent Claim
12 words
The method of claim 16 wherein the textile is a woven fabric.
Claim 20
Dependent Claim
12 words
The method of claim 16 wherein the textile is a knitted fabric.
Claim 21
Dependent Claim
21 words
The method of claim 15 wherein the surfactant comprises a polysorbate surfactant, a polyethoxy ethanol surfactant, or a polyether alcohol surfactant.
Claim 22
Dependent Claim
13 words
The method of claim 15 wherein the substrate is immersed in the surfactant.
Claim 23
Dependent Claim
23 words
The method of claim 15 wherein the gelable material is a bioerodable polymer selected from the group consisting of polysaccharides, glycosaminoglycans and proteins.
Claim 24
Dependent Claim
21 words
The method of claim 15 wherein the gelable material is selected from the group consisting of albumin, gelatin, collagen and fibrinogen.
Claim 25
Dependent Claim
23 words
The method of claim 15 wherein the substrate is loaded by wicking the carrying volume of the gelable material solution into the substrate.
Claim 26
Dependent Claim
23 words
The method of claim 15 wherein the substrate is loaded by dripping the carrying volume of the gelable material solution onto the substrate.
Claim 27
Dependent Claim
23 words
The method of claim 15 wherein the substrate is loaded by spraying the carrying volume of the gelable material solution onto the substrate.
Claim 28
Dependent Claim
14 words
The method of claim 15 wherein the crosslinking is achieved using a crosslinking agent.
Claim 29
Dependent Claim
24 words
The method of claim 26 wherein the crosslinking agent comprises a material selected from the group consisting of formaldehydes, dialdehyde starches, carbodiimides and glutaraldehydes.
Claim 30
Dependent Claim
12 words
The method of claim 27 wherein the carbodiimide comprises 1-ethyl-3-(3-dimethyl-aminopropyl) carbodiimide hydrochloride.
Claim 31
Dependent Claim
20 words
The method of claim 26 wherein the crosslinking agent is mixed with the gelable material prior to the loading step.
Claim 32
Dependent Claim
23 words
The method of claim 20 wherein the resulting graft includes between approximately 0.24 and 0.32 grams of gelled protein per gram of fabric.
Claim 33
Dependent Claim
14 words
The method of claim 15 wherein the humectant comprises an aqueous solution of glycerol.
Claim 34
Dependent Claim
56 words
In the method of forming a vascular prosthesis which comprises a porous textile tube impregnated with a gelled material, the improvement which comprises determining a carrying volume for the porous textile tube of a gelable material solution, and impregnating in a single application the porous textile tube with the carrying volume of the gelable material solution.
Claim 35
Dependent Claim
56 words
In the method of forming a vascular prosthesis which comprises a porous textile tube impregnated with a gelled material, the improvement which comprises determining a carrying volume for the porous textile tube of a gelable material solution, and impregnating in a single application the porous textile tube with the carrying volume of the gelable material solution.
Claim 36
Dependent Claim
27 words
The improvement of claim 32 wherein the material comprises a polysaccharide, a glycosaminoglycan or a protein selected from the group consisting of albumin, gelatin, collagen and fibrinogen.
Claim 37
Dependent Claim
9 words
The product produced by the method of claim 1.
Claim 38
Dependent Claim
9 words
The product produced by the method of claim 15.
Claim 39
Independent Claim
71 words
A method for producing a vascular graft comprising a porous substrate impregnated with a biocompatible material, the method comprising the steps of: (a) immersing the substrate in a liquid bath, (b) exposing the-substrate to ultrasonic agitation, (c) removing the substrate from the bath, (d) drying the substrate, and (e) impregnating the substrate with a biocompatible material, by applying in a single application to the substrate a carrying volume for the substrate.
Claim 40
Independent Claim
71 words
A method for producing a vascular graft comprising a porous substrate impregnated with a biocompatible material, the method comprising the steps of: (a) immersing the substrate in a liquid bath, (b) exposing the-substrate to ultrasonic agitation, (c) removing the substrate from the bath, (d) drying the substrate, and (e) impregnating the substrate with a biocompatible material, by applying in a single application to the substrate a carrying volume for the substrate.
Claim 41
Dependent Claim
20 words
The method of claim 36 wherein the liquid bath comprises an alcohol, water, or a mixture of alcohol and water.
Claim 42
Dependent Claim
18 words
The method of claim 37 wherein the alcohol is selected from the group consisting of methanol and ethanol.
Claim 43
Dependent Claim
47 words
A method as claimed in Claim 1 further comprising the steps: (f) immersing the substrate in a liquid bath, (g) exposing the substrate to ultrasonic agitation, and (h) removing the substrate from the bath, wherein the steps (f), (g) and (h) are performed prior to step (d).
Claim 44
Dependent Claim
13 words
The method of claim 36 wherein the biocompatible material is a gelable material.
Claim 45
Dependent Claim
66 words
In the method of forming a vascular prosthesis, which comprises a porous textile tube having interstices by impregnating the vascular prosthesis with gelled material, the improvement which comprises applying in a single application to the porous textile tube a carrying volume for the porous textile tube of a gelable material to fill the interstices, and causing the gelable material to form a gel within the interstices.
Claim 46
Dependent Claim
66 words
In the method of forming a vascular prosthesis, which comprises a porous textile tube having interstices by impregnating the vascular prosthesis with gelled material, the improvement which comprises applying in a single application to the porous textile tube a carrying volume for the porous textile tube of a gelable material to fill the interstices, and causing the gelable material to form a gel within the interstices.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-12-17 | 2000-06-17 | 2000-12-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-12-17 | 2004-06-17 | 2004-12-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-12-17 | 2008-06-17 | 2008-12-17 | $7700.00 | Window Closed / Lapsed |