US4329383A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Non-thrombogenic material comprising substrate which has been reacted with heparin
Assignee: Zeon Corp
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Filing: 1980-07-21
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Granted: 1982-05-11
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Expires: 2000-07-21
Abstract
Abstract Non-thrombogenic material comprising a base polymer treated with heparin, the improvement in which the heparin is covalently bonded with the base polymer through only one acetal bond or hemiacetal bond at each bonding site between the heparin and the base polymer.
Inventors
- 👤 Yasushi Joh
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 09:55
CPC Classifications
A; A61; A61L; A61L33/00; A61L33/0005; A61L33/0011; Y; Y10; Y10S; Y10S623/00; Y10S623/924; Y10T; Y10T428/00; Y10T428/29; Y10T428/2913; Y10T428/2933; Y10T428/2935; Y10T428/2973; Y10T428/2975; Y10T428/31504; Y10T428/31971
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
43 words
A shaped article comprising a hollow fiber having an interior wall with a non-thrombogenic surface, said non-thrombogenic surface being prepared by reacting an aldehyde group or aldehyde groups or an aldehyde forming group or aldehyde forming groups on the interior wall with heparin.
Claim 2
Dependent Claim
43 words
A shaped article comprising a hollow fiber having an interior wall with a non-thrombogenic surface, said non-thrombogenic surface being prepared by reacting an aldehyde group or aldehyde groups or an aldehyde forming group or aldehyde forming groups on the interior wall with heparin.
Claim 3
Dependent Claim
28 words
The shaped article according to claim 1 wherein said heparin was contained in a core liquid which was extruded simultaneously with said dope to spin said hollow fiber.
Claim 4
Dependent Claim
67 words
The shaped article according to claim 1, wherein said hollow fiber was spun by extruding a dope of cellulose ester while simultaneously extruding an aqueous core liquid that contained a salt for developing a phase separation between said dope and said core liquid and a cleaving agent for cleaving carbon-carbon bonds between carbon atoms of said cellulose ester with vicinal hydroxyl groups, thereby developing said aldehyde groups.
Claim 5
Dependent Claim
44 words
The shaped article according to claim 3, wherein said core liquid further contained a hydrolyzing agent which hydrolyzed said cellulose ester at the interior wall of said hollow fiber to produce regenerated cellulose possessing vicinal hydroxyl groups which then reacted with said cleaving agent.
Claim 6
Dependent Claim
24 words
The shaped article according to claim 3 wherein said core liquid was an organic liquid containing periodic acid which did not gel said dope.
Claim 7
Dependent Claim
22 words
The shaped article according to claim 3 wherein said cleaving agent was periodic acid, a salt of periodic acid or lead tetraacetate.
Claim 8
Dependent Claim
67 words
A shaped article selected from the group consisting of a tube, a hollow fiber, a film and a sheet, coated with a non-thrombogenic material prepared by reacting cellulose ester with a cleaving agent to develop adjacent aldehyde groups on said cellulose ester and binding heparin to said adjacent aldehyde groups through acetal bond or hemiacetal bond at each bonding site between said heparin and said cellulose ester.
Claim 9
Dependent Claim
67 words
A shaped article selected from the group consisting of a tube, a hollow fiber, a film and a sheet, coated with a non-thrombogenic material prepared by reacting cellulose ester with a cleaving agent to develop adjacent aldehyde groups on said cellulose ester and binding heparin to said adjacent aldehyde groups through acetal bond or hemiacetal bond at each bonding site between said heparin and said cellulose ester.
Claim 10
Dependent Claim
19 words
The shaped article according to claim 7 wherein the non-thrombogenic material was made insoluble by cross-linking with a dialdehyde.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-05-10 | 1985-11-09 | 1986-05-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-05-10 | 1989-11-09 | 1990-05-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-05-10 | 1993-11-09 | 1994-05-11 | $7700.00 | Window Closed / Lapsed |