US4670286A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of forming prosthetic devices
Assignee: United States Surgical Corp
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Filing: 1985-12-26
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Granted: 1987-06-02
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Expires: 2005-12-26
Abstract
Abstract A sterile shaped prosthetic device, suitable for insertion into a mammalian body, is at least partly composed of a bioresorbable material that is digestible by macrophages, its surface properties favor the attachment and adhesion of fibroblast cells capable of producing collagen for organized connective tissues, and the material itself or its degradation products can induce in vivo the formation of new capillary vessels (termed a "vasotropic" effect herein). Preferred prosthetic devices have through passages, the interspatial dimensions which are sufficient to permit several layers of mammalian cells to form within each passage. The invading fibroblast cells commence formation of collagen leading to connective tissue while macrophages and extracellular enzymes degrade the material, and newly formed capillary vessels penetrate the prosthesis and provide blood containing oxygen and nutrients which further the formation of organized tissue around as well as within the prosthetic device.
Inventors
- 👤 Emery Nyilas
- 👤 Tin-Ho Chiu
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:45
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/50; A61L27/58; A61F; A61F2/00; A61F2/02; A61F2/04; A61F2/06; A61L27/14; A61L27/18; A61F2210/00; A61F2210/0004
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
77 words
A method of forming a prosthetic fabric device at least a portion of which is of a bioresorbable material whose surface properties favor fibroblast cell attachment and adhesion, and also encourage the infiltration of macrophages comprising the steps of dipping said device at a controlled rate into a solution of a bioresorbable, vasotropic effect inducing material, partial drying and inverting said device and redipping said device in said solution to form a bioresorbable coating on said device.
Claim 2
Independent Claim
77 words
A method of forming a prosthetic fabric device at least a portion of which is of a bioresorbable material whose surface properties favor fibroblast cell attachment and adhesion, and also encourage the infiltration of macrophages comprising the steps of dipping said device at a controlled rate into a solution of a bioresorbable, vasotropic effect inducing material, partial drying and inverting said device and redipping said device in said solution to form a bioresorbable coating on said device.
Claim 3
Dependent Claim
16 words
The method of claim 1 wherein said device is a fabric of bioresorbable and nonbioresorbable yarns.
Claim 4
Dependent Claim
53 words
The method of claim 2 and including after said redipping the further steps of stretching said coated fabric and dipping said stretched fabric in a solution of bioresorbable, vasotropic effect inducing material to form a prosthetic fabric article that has a leak rate of less than about 100 cm -2 min -1 .
Claim 5
Dependent Claim
25 words
The method of claim 1 wherein said bioresorbable, vasotropic effect inducing material is a polyester derived from a Krebs-Cycle dicarboxylic acid and a metabolizable diol.
Claim 6
Dependent Claim
20 words
The method of claim 4 wherein said polyester is selected from the class consisting of poly(D,L-lactic acid) and poly(2,3-butylene succinate).
Claim 7
Dependent Claim
19 words
The method of claim 2 wherein the bioresorbable yarns are present in an amount of at least about 15%.
Claim 8
Dependent Claim
19 words
The method of claim 2 wherein the bioresorbable yarns are present in an amount of about 65% to 80%.
Claim 9
Dependent Claim
16 words
The method of claim 5 wherein the bioresorbable, vasotropic effect inducing material is a synthetic polymer.
Claim 10
Dependent Claim
16 words
The method of claim 5 wherein the bioresorbable, vasotropic effect inducing material is poly (D,L-lactic acid).
Claim 11
Independent Claim
77 words
A method of forming a tubular vascular fabric prothesis at least a portion of which is of a bioresorbable material whose surface properties favor fibroblast cell attachment and adhesion, and also encourage the infiltration of macrophages comprising the steps of dipping said device at a controlled rate into a solution of synthetic bioresorbable, vasotropic effect inducing material partial drying inverting said device and redipping said device in said solution to form a bioresorbable coating on said device.
Claim 12
Independent Claim
77 words
A method of forming a tubular vascular fabric prothesis at least a portion of which is of a bioresorbable material whose surface properties favor fibroblast cell attachment and adhesion, and also encourage the infiltration of macrophages comprising the steps of dipping said device at a controlled rate into a solution of synthetic bioresorbable, vasotropic effect inducing material partial drying inverting said device and redipping said device in said solution to form a bioresorbable coating on said device.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-06-01 | 1990-12-01 | 1991-06-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-06-01 | 1994-12-01 | 1995-06-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-06-01 | 1998-12-01 | 1999-06-02 | $7700.00 | Window Closed / Lapsed |