US5376375A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of augmenting tissue using collagen-polymer conjugates
Assignee: Surgical Specialties US Corp
•
Filing: 1994-01-05
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Granted: 1994-12-27
•
Expires: 2014-01-05
Abstract
Abstract Collagen, particularly atelopeptide collagen, exhibits improved handling characteristics when chemically conjugated and/or crosslinked with a synthetic hydrophilic polymer.
Inventors
- 👤 Woonza Rhee
- 👤 Donald G. Wallace
- 👤 Alan S. Michaels
- 👤 Ramon A. Burns, Jr.
- 👤 Louis Fries
- 👤 Frank DeLustro
- 👤 Hanne Bentz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:32
CPC Classifications
C; C08; C08L; C08L89/00; C08L89/04; C08L89/06; A; A61; A61L; A61L24/00; A61L24/04; A61L24/10; A61L24/102; A61L27/00; A61L27/14; A61L27/22; A61L27/24; A61L27/26; A61L27/28; A61L27/34; A61L27/40; A61L27/44; A61L27/50; A61L27/54; A61L31/00; A61L31/04; A61L31/041; A61L31/043; A61L31/044; A61L31/08; A61L31/10; A61L31/12; A61L31/125; C08H; C08H1/00; C08H1/06; C09; C09J; C09J189/00; C09J189/04; C09J189/06; A61F; A61F2/00; A61F2/02; A61F2/04; A61F2/06; A61F2/07; A61F2310/00; A61F2310/00005; A61F2310/00365; A61L2300/00; A61L2300/40; A61L2300/412; A61L2300/414; A61L2300/426; A61L2300/60; A61L2300/602; A61L2430/00; A61L2430/02; A61L2430/16; C08L2666/00; C08L2666/02; Y; Y10; Y10S; Y10S525/00; Y10S525/935; Y10S525/937; Y10S530/00; Y10S530/827; Y10S530/84
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
99 words
A method for augmenting tissue in a mammal, which comprises: providing an aqueous collagen mixture having a concentration of about 10 to about 100 mg/mL collagen; providing an aqueous solution of synthetic hydrophilic polymer having a reactive group capable of forming a covalent bond in situ with an available lysine side chain present in collagen; mixing said collagen mixture and said polymer solution to form a reaction mixture having a polymer concentration of about 0.1 to about 10% polymer having reactive groups; and administering said reaction mixture at a site in need of augmentation before substantial collagen-polymer crosslinking occurs.
Claim 2
Independent Claim
99 words
A method for augmenting tissue in a mammal, which comprises: providing an aqueous collagen mixture having a concentration of about 10 to about 100 mg/mL collagen; providing an aqueous solution of synthetic hydrophilic polymer having a reactive group capable of forming a covalent bond in situ with an available lysine side chain present in collagen; mixing said collagen mixture and said polymer solution to form a reaction mixture having a polymer concentration of about 0.1 to about 10% polymer having reactive groups; and administering said reaction mixture at a site in need of augmentation before substantial collagen-polymer crosslinking occurs.
Claim 3
Dependent Claim
22 words
The method of claim 1 wherein said polymer comprises polyethylene glycol having an average molecular weight of about 400 to about 20,000.
Claim 4
Dependent Claim
12 words
The method of claim 2 wherein said reactive groups comprise N-hydroxysuccinimide esters.
Claim 5
Dependent Claim
15 words
The method of claim 1 wherein said collagen comprises fibrillar atelopeptide collagen or nonfibrillar collagen.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-12-26 | 1998-06-27 | 1998-12-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-12-26 | 2002-06-27 | 2002-12-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-12-26 | 2006-06-27 | 2006-12-27 | $7700.00 | Window Closed / Lapsed |