US4592864A
Expired / Lapsed
US
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Aqueous atelocollagen solution and method of preparing same
Assignee: Koken Co Ltd
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Filing: 1984-07-25
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Granted: 1986-06-03
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Expires: 2004-07-25
Abstract
Abstract An aqueous atelocollagen solution, which can be injected into living bodies as a medical material, has a pH value in the range from about 6.5 to about 8.0 and an osmolality in the range from about 250 to about 320 mOsm/KgH 2 O, and contains a phosphate buffer solution, or glucose and a phosphate buffer solution, as an agent to adjust pH and osmolality within the ranges specified above. This aqueous atelocollagen solution can be prepared by dissolving atelocollagen in an aqueous acidic solution and adding the above-mentioned pH- and osmolality-adjusting agent to the resulting solution in such an amount as to adjust pH and osmolality of the final solution within the ranges mentioned above.
Inventors
- 👤 Teruo Miyata
- 👤 Toshio Taira
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 09:33
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/78
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
34 words
An aqueous atelocollagen solution comprising dissolved atelocollagen, having a pH in the range from about 6.5 to about 8.0 and an osmolality in the range from about 250 to about 320 mOsm/KgH 2 O.
Claim 2
Dependent Claim
34 words
An aqueous atelocollagen solution comprising dissolved atelocollagen, having a pH in the range from about 6.5 to about 8.0 and an osmolality in the range from about 250 to about 320 mOsm/KgH 2 O.
Claim 3
Dependent Claim
53 words
An aqueous atelocollagen solution as defined in claim 1 containing, as pH- and osmolality-adjusting agent, a phosphate buffer solution selected from the group consisting of combinations, KH 2 PO 4 --K 2 HPO 4 , KH 2 PO 4 --Na 2 HPO 4 and NaH 2 PO 4 --Na 2 HPO 4 .
Claim 4
Dependent Claim
55 words
An aqueous atelocollagen solution as defined in claim 1 containing, as pH- and osmolality-adjusting agent, glucose and a phosphate buffer solution selected from the group consisting of combinations, KH 2 PO 4 --K 2 HPO 4 , KH 2 PO 4 --Na 2 HPO 4 and NaH 2 PO 4 --Na 2 HPO 4 .
Claim 5
Independent Claim
58 words
A method of preparing aqueous atelocollagen solution, which comprises dissolving atelocollagen in an aqueous acidic solution and adding, to the resulting solution, a pH- and osmolality-adjusting agent in such an amount as to give a pH value in the range from about 6.5 to about 8.0 and an osmolality from about 250 to about 320 mOsm/KgH 2 O.
Claim 6
Independent Claim
58 words
A method of preparing aqueous atelocollagen solution, which comprises dissolving atelocollagen in an aqueous acidic solution and adding, to the resulting solution, a pH- and osmolality-adjusting agent in such an amount as to give a pH value in the range from about 6.5 to about 8.0 and an osmolality from about 250 to about 320 mOsm/KgH 2 O.
Claim 7
Dependent Claim
58 words
A method of preparing aqueous atelocollagen solution as defined in claim 4 wherein said pH- and osmolality adjusting agent is a phosphate buffer solution selected from the group consisting of combinations, KH 2 PO 4 --K 2 HPO 4 , KH 2 PO 4 --Na 2 HPO 4 and NaH 2 PO 4 --Na 2 HPO 4 .
Claim 8
Dependent Claim
58 words
A method of preparing aqueous atelocollagen solution as defined in claim 4, wherein said pH- and osmolality-adjusting agent comprises glucose and a phosphate buffer selected from the group consisting of combinations, KH 2 PO 4 --K 2 HPO 4 , KH 2 PO 4 --Na 2 HPO 4 and NaH 2 PO 4 --Na 2 HPO 4 .
Claim 9
Dependent Claim
23 words
An aqueous atelocollagen solution as defined in claim 1 which is capable of being injected into living bodies through a fine syringe needle.
Claim 10
Dependent Claim
23 words
An aqueous atelocollagen as defined in claim 1 which is capable of passing through a filter having a pore size of 0.45 microns.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-06-02 | 1989-12-02 | 1990-06-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-06-02 | 1993-12-02 | 1994-06-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-06-02 | 1997-12-02 | 1998-06-03 | $7700.00 | Window Closed / Lapsed |