US4055635A
Expired / Lapsed
US
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Fibrinolytic compositions
Assignee: Beecham Group PLC
•
Filing: 1974-07-02
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Granted: 1977-10-25
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Expires: 1994-07-02
Abstract
Abstract Fibrinolytic pharmaceutical compositions are provided in unit dosage form and comprise a water-soluble complex of a proteolytic enzyme linked covalently to a polymeric substance.
Inventors
- 👤 Joseph Green
- 👤 Michael Anthony Cawthorne
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:21
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/43; A61K38/46; A61K38/48; A61K38/482; A61K38/4826; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/59; A61K47/60; A61K47/61; C; C12; C12N; C12N11/00; C12N11/02; C12N11/10
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
81 words
A fibrinolytic pharmaceutical composition in unit dosage form suitable for administration by injection to humans which comprises an amount of a water soluble complex of a proteolytic enzyme sufficient to achieve the desired degree of fibrinolysis on administration to a human and linked covalently to a water-soluble polymeric substance having a molecular weight of from 10,000 to 500,000, said enzyme and said polymeric substance being present in the ratio of 1:2 to 1:50 said composition being substantially free of unreacted enzyme.
Claim 2
Dependent Claim
81 words
A fibrinolytic pharmaceutical composition in unit dosage form suitable for administration by injection to humans which comprises an amount of a water soluble complex of a proteolytic enzyme sufficient to achieve the desired degree of fibrinolysis on administration to a human and linked covalently to a water-soluble polymeric substance having a molecular weight of from 10,000 to 500,000, said enzyme and said polymeric substance being present in the ratio of 1:2 to 1:50 said composition being substantially free of unreacted enzyme.
Claim 3
Dependent Claim
18 words
A composition according to claim 1 wherein the proteolytic enzyme is trypsin, chymotripsin, bromelain, papain, pronase or brinase.
Claim 4
Dependent Claim
13 words
A composition according to claim 2 wherein the enzyme is trypsin or pronase.
Claim 5
Dependent Claim
14 words
A composition according to claim 1 wherein the water-soluble polymeric substance is a polysaccharide.
Claim 6
Dependent Claim
12 words
A composition according to claim 4 wherein the polysaccharide is a dextran.
Claim 7
Dependent Claim
13 words
A composition according to claim 4 wherein the polysaccharide is a modified polysaccharide.
Claim 8
Dependent Claim
14 words
A composition according to claim 6 wherein the modified polysaccharide is a sucrose-epichlorhydrin copolymer.
Claim 9
Dependent Claim
26 words
A composition according to claim 1 in the form of a sealed ampoule containing a predetermined amount of the enzyme complex in a sterile freeze-dried form.
Claim 10
Dependent Claim
34 words
A composition according to claim 1 in a form suitable for injection into humans wherein the enzyme complex is dissolved or suspended in sterile or pyrogen-free water or isotonic saline, at a predetermined concentration.
References Cited (Backward Citations)
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US3691090A
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Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-10-24 | 1981-04-25 | 1981-10-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-10-24 | 1985-04-25 | 1985-10-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-10-24 | 1989-04-25 | 1989-10-25 | $7700.00 | Window Closed / Lapsed |