Abstract The invention relates to a composite polymeric material suitable for biological and medical applications and to the method for preparation thereof. The composite material consists of 1-99 wt. % of hydrophilic polymer or copolymer based on methacrylic or acrylic esters, 1-99 wt. % of fibrillar collagen, and up to 2.5 wt. % of a crosslinking agent, based on both polymeric components. The composite material may further comprise biologically active compounds and other auxiliary materials, as fillers and/or plasticizers. The composite material is prepared by dispersing the fibrillar collagen in a solution or a highly swollen dispersion of the synthetic hydrophilic polymer or copolymer in a lytropic agent and the subsequent removal of the lyotropic agent, thus forming a matrix of the synthetic polymer or copolymer penetrated by fibrillar collagen or vice versa. The composite material may be applied on a solid support or reinforced with glass, plastics, cellulose, or metallic materials.
Composite polymeric material for biological and medical application comprising a matrix of at least the following components: 1-99 weight percent of a substantially water insoluble hydrophilic polymer or copolymer based on methacrylate or acrylate, 1-99 weight percent of a fibrillar collagen, 0-2.5 weight percent of a crosslinking agent, related to both polymeric components, said material being prepared by dispersing the fibrillar collagen in a solution or in a high swollen dispersion of the synthetic hydrophilic polymer or copolymer in a lyotropic agent which maintains the mutual miscibility of said components and by the subsequent removal of the lyotropic agent forming a matrix of said synthetic polymer or copolymer interpregnated with collagen or a matrix of collagen interpregnated with said synthetic polymer or copolymer.
Claim 2
Dependent Claim
123 words
Composite polymeric material for biological and medical application comprising a matrix of at least the following components: 1-99 weight percent of a substantially water insoluble hydrophilic polymer or copolymer based on methacrylate or acrylate, 1-99 weight percent of a fibrillar collagen, 0-2.5 weight percent of a crosslinking agent, related to both polymeric components, said material being prepared by dispersing the fibrillar collagen in a solution or in a high swollen dispersion of the synthetic hydrophilic polymer or copolymer in a lyotropic agent which maintains the mutual miscibility of said components and by the subsequent removal of the lyotropic agent forming a matrix of said synthetic polymer or copolymer interpregnated with collagen or a matrix of collagen interpregnated with said synthetic polymer or copolymer.
Claim 3
Dependent Claim
29 words
The composite polymeric material according to claim 1 wherein said hydrophilic polymer or copolymer has a molecular weight in the range of from 10 4 to 10 6 .
Claim 4
Dependent Claim
15 words
The composite polymeric material according to claim 1 including at least one biologically active compound.
Claim 5
Dependent Claim
21 words
The composite polymeric material according to claim 1 including an auxiliary material selected from the group consisting of plasticisers and fillers.
Claim 6
Dependent Claim
16 words
The composite material according to claim 1 wherein said material is applied on a solid base.
Claim 7
Dependent Claim
26 words
The composite material according to claim 1 wherein said material is reinforced with a solid material selected from the group comprising glass, plastics, cellulose and metals.