US5047020A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Ionic heparin coating
Assignee: Edwards Lifesciences Corp
•
Filing: 1989-07-31
•
Granted: 1991-09-10
•
Expires: 2009-07-31
Abstract
Abstract A non thrombogenic quaternary ammonium-heparin complex coating for a medical article comprising an amount of at least 50% by weight of one or more cationic quaternary ammonium organic salts having the following formula: ##STR1## Wherein R 1 is an alkyl group having from about 14 to about 22 carbons; R 2 is an alkyl group having from about 1 to about five carbons; R 3 is an alkyl group having from about 1 to about five carbons.
Inventors
- 👤 Li-Chien Hsu
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 00:38
CPC Classifications
A; A61; A61L; A61L33/00; A61L33/0005; A61L33/0011; A61L33/0017
Claims Analysis
Total Claims: 35
Claim 1
Independent Claim
82 words
A blood contacting medical article comprising: a. a substrate surface; and b. an anti-thrombogenic surface coating of a complex of heparin and at least 50% by weight of a cationic trialkylbenzyl ammonium salt having the following formula: ##STR8## wherein R 1 is an alkyl group having from about 14 to about 22 carbons; R 2 is an alkyl group having from about 1 to about five carbons; and R 3 is an alkyl group having from about 1 to about five carbons.
Claim 2
Dependent Claim
82 words
A blood contacting medical article comprising: a. a substrate surface; and b. an anti-thrombogenic surface coating of a complex of heparin and at least 50% by weight of a cationic trialkylbenzyl ammonium salt having the following formula: ##STR8## wherein R 1 is an alkyl group having from about 14 to about 22 carbons; R 2 is an alkyl group having from about 1 to about five carbons; and R 3 is an alkyl group having from about 1 to about five carbons.
Claim 3
Dependent Claim
14 words
The medical article of claim 1 wherein the complex is Myristyl dimethyl benzyl ammonium/heparin.
Claim 4
Dependent Claim
14 words
The medical article of claim 1 wherein the complex is Eicosane dimethyl benzyl ammonium/heparin.
Claim 5
Dependent Claim
14 words
The medical article of claim 1 wherein the complex is Docosane dimethyl benzyl ammonium/heparin.
Claim 6
Dependent Claim
14 words
The medical article of claim 1 wherein the complex is Stearyl dipentyl benzyl ammonium/heparin.
Claim 7
Dependent Claim
14 words
The medical article of claim 1 wherein the complex is Stearyl dibutyl benzyl ammonium/heparin.
Claim 8
Dependent Claim
15 words
The medical article of claim 1 wherein the complex is Stearyl methyl butyl benzyl ammonium/heparin.
Claim 9
Dependent Claim
14 words
The medical article of claim 1 wherein the substrate surface comprises a polymeric resin.
Claim 10
Dependent Claim
26 words
The medical article of claim 1 wherein the organic cationic salt is present in an amount of 60 to 70% by weight of the complex composition.
Claim 11
Dependent Claim
17 words
The medical article of claim 1 wherein R 1 is an alkyl group having about 14 carbons.
Claim 12
Dependent Claim
17 words
The medical article of claim 1 wherein R 1 is an alkyl group having about 15 carbons.
Claim 13
Dependent Claim
21 words
The medical article of claim 1 wherein R 1 is an alkyl group having from about 16 to about 18 carbons.
Claim 14
Dependent Claim
21 words
The medical article of claim 1 wherein R 1 is an alkyl group having from about 19 to about 22 carbons.
Claim 15
Dependent Claim
21 words
The medical article of claim 1 wherein R 2 is an alkyl group having from about 2 to about 5 carbons.
Claim 16
Dependent Claim
21 words
The medical article of claim 1 wherein R 3 is an alkyl group having from about 2 to about 5 carbons.
Claim 17
Dependent Claim
92 words
A process for rendering the surfaces of blood contacting medical articles non-thrombogenic comprising. a. providing a medical article; and b. coating the medical article with a complex of heparin and at least 50% by weight of one or more trialkylbenzyl dimethyl ammonium cationic salt of the formula: ##STR9## wherein R 1 is an alkyl group having from about 14 to about 22 carbons; R 2 is an alkyl group having from about 1 to about five carbons; and R 3 is an alkyl group having from about 1 to about five carbons.
Claim 18
Dependent Claim
92 words
A process for rendering the surfaces of blood contacting medical articles non-thrombogenic comprising. a. providing a medical article; and b. coating the medical article with a complex of heparin and at least 50% by weight of one or more trialkylbenzyl dimethyl ammonium cationic salt of the formula: ##STR9## wherein R 1 is an alkyl group having from about 14 to about 22 carbons; R 2 is an alkyl group having from about 1 to about five carbons; and R 3 is an alkyl group having from about 1 to about five carbons.
Claim 19
Dependent Claim
43 words
The process of claim 16 wherein the coating step comprises: a. providing an organic solution of the heparin complex; b. applying the solution to the surface of a medical article; and c. drying the medical article to form an integral adhesive coating thereon.
Claim 20
Dependent Claim
16 words
The process of claim 16 wherein R 1 is an alkyl group having about 14 carbons.
Claim 21
Dependent Claim
16 words
The process of claim 16 wherein R 1 is an alkyl group having about 15 carbons.
Claim 22
Dependent Claim
20 words
The process of claim 16 wherein R 1 is an alkyl group having from about 16 to about 18 carbons.
Claim 23
Dependent Claim
19 words
The process of claim 16 wherein R 1 is an alkyl group from about 19 to about 22 carbons.
Claim 24
Dependent Claim
20 words
The process of claim 16 wherein R 2 is an alkyl group having from about 2 to about 5 carbons.
Claim 25
Dependent Claim
20 words
The process of claim 16 wherein R 3 is an alkyl group having from about 2 to about 5 carbons.
Claim 26
Dependent Claim
113 words
A process for rendering the surfaces of blood contacting medical articles non-thrombogenic comprising: a. providing a medical article; and b. treating the medical article with a solution of at least 50% by weight of one or more trialkylbenzyl cationic quaternary ammonium organic salts having the following formula: ##STR10## wherein R 1 is an alkyl group having from about 14, 15 or 19 to about 22 carbons; R 2 is an alkyl group having from about 1 to about five carbons; R 3 is an alkyl group having from about 1 to about five carbons; and X is a halogen; and c. subsequently treating the medical article with an aqueous solution of heparin salt.
Claim 27
Dependent Claim
113 words
A process for rendering the surfaces of blood contacting medical articles non-thrombogenic comprising: a. providing a medical article; and b. treating the medical article with a solution of at least 50% by weight of one or more trialkylbenzyl cationic quaternary ammonium organic salts having the following formula: ##STR10## wherein R 1 is an alkyl group having from about 14, 15 or 19 to about 22 carbons; R 2 is an alkyl group having from about 1 to about five carbons; R 3 is an alkyl group having from about 1 to about five carbons; and X is a halogen; and c. subsequently treating the medical article with an aqueous solution of heparin salt.
Claim 28
Dependent Claim
21 words
The process of claim 24 wherein the organic cationic salt consists of an alkyl R 1 group of 16 carbon atoms.
Claim 29
Dependent Claim
20 words
The process of claim 24 wherein the organic cationic salt consists of an alkyl R group of 18 carbon atoms.
Claim 30
Dependent Claim
16 words
The process of claim 24 wherein R 1 is an alkyl group having about 14 carbons.
Claim 31
Dependent Claim
16 words
The process of claim 24 wherein R 1 is an alkyl group having about 15 carbons.
Claim 32
Dependent Claim
20 words
The process of claim 24 wherein R 1 is an alkyl group having from about 16 to about 18 carbons.
Claim 33
Dependent Claim
20 words
The process of claim 24 wherein R 1 is an alkyl group having from about 19 to about 22 carbons.
Claim 34
Dependent Claim
20 words
The process of claim 24 wherein R 2 is an alkyl group having from about 2 to about 5 carbons.
Claim 35
Dependent Claim
20 words
The process of claim 24 wherein R 3 is an alkyl group having from about 2 to about 5 carbons.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-09-09 | 1995-03-11 | 1995-09-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-09-09 | 1999-03-11 | 1999-09-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-09-09 | 2003-03-11 | 2003-09-10 | $7700.00 | Window Closed / Lapsed |