US4565740A
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US
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Surface modified solid substrate and a method for its preparation
Assignee: Ird-Biomaterial AB
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Filing: 1983-02-08
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Granted: 1986-01-21
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Expires: 2003-02-08
Abstract
Abstract A surface modified substrate, wherein the substrate carries a complex adsorbed thereto, which complex is of a polymeric cationic surfactant that contains primary amino nitrogens as well as secondary and/or tertiary amino nitrogens, and a dialdehyde that has 1-4 carbon atoms between the two aldehyde groups. To said complex there may additionally be bonded an anionic compound and optionally alternatingly additional cationic and anionic compounds. The modification primarily means that positive or negative charges can be imparted to the original substrate. Secondly, however, the point may be to utilize reactive groups in bonded cationic or anionic compounds. The surface modified substrate is prepared by contacting the substrate with the polymeric cationic surfactant and the dialdehyde at such conditions that a complex is formed, which is adsorbed onto the substrate surface, and optionally continuing the ionic bonding with an anionic compound and possibly also alternatingly additional cationic and anionic compounds. The polymeric cationic surfactant and the dialdehyde are preferably utilized, separately or together, dissolved in a polar solvent, preferably water. The formation of the complex takes place at a pH-value above 8, whereupon the charges are preferably created at a pH-value below 7.
Inventors
- 👤 Carl-Gustaf Golander
- 👤 Rolf Larsson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 23:37
CPC Classifications
A; A61; A61L; A61L33/00; A61L33/0005; A61L33/0011; A61L33/0029; A61L33/02; C; C08; C08B; C08B37/00; C08K; C08K3/00; C08K3/02; C08K3/08; C08K3/40; Y; Y10; Y10T; Y10T428/00; Y10T428/13; Y10T428/131; Y10T428/1317; Y10T428/1321; Y10T428/1352; Y10T428/1355; Y10T428/1379; Y10T428/1386; Y10T428/26; Y10T428/269; Y10T428/31; Y10T428/31504; Y10T428/3154; Y10T428/31551; Y10T428/31678; Y10T428/31725; Y10T428/31855; Y10T428/31909; Y10T428/31913; Y10T428/3192; Y10T428/31971
Claims Analysis
Total Claims: 41
Claim 1
Independent Claim
50 words
A surface modified solid substrate, wherein the substrate carries a complex adsorbed thereto which complex is of a polymeric cationic surfactant and a dialdehyde, the surfactant containing primary amino nitrogens as well as secondary and/or tertiary amino nitrogens, and the dialdehyde having 1-4 carbon atoms between the two aldehyde groups.
Claim 2
Dependent Claim
50 words
A surface modified solid substrate, wherein the substrate carries a complex adsorbed thereto which complex is of a polymeric cationic surfactant and a dialdehyde, the surfactant containing primary amino nitrogens as well as secondary and/or tertiary amino nitrogens, and the dialdehyde having 1-4 carbon atoms between the two aldehyde groups.
Claim 3
Dependent Claim
24 words
A surface modified substrate according to claim 1 wherein the polymeric cationic surfactant contains at least two primary amino groups in each polymer molecule.
Claim 4
Dependent Claim
23 words
A surface modified substrate according to claim 2, wherein the polymeric cationic surfactant is selected from the group consisting of polyimines and polyamides.
Claim 5
Dependent Claim
16 words
A surface modified substrate according to claim 1, wherein the polymeric cationic surfactant is a polyalkyleneimine.
Claim 6
Dependent Claim
26 words
A surface modified substrate according to claim 1, wherein the polymeric cationic surfactant has 1-6 carbon atoms between the amino nitrogen atoms in the polymer molecule.
Claim 7
Dependent Claim
16 words
A surface modified substrate according to claim 1, wherein the polymeric cationic surfactant is a polyethyleneimine.
Claim 8
Dependent Claim
13 words
A surface modified substrate according to claim 1, wherein the dialdehyde is glutardialdehyde.
Claim 9
Dependent Claim
35 words
A surface modified substrate according to claim 1, wherein the substrate is selected from the group consisting of stainless steel, glass or a polymeric material selected from polyvinylchloride, polyurethanes, silicon rubber, polytetrafluoroethylene, polystyrene, and polyolefins.
Claim 10
Dependent Claim
13 words
A surface modified substrate according to claim 8, wherein the substrate is polyethylene.
Claim 11
Dependent Claim
27 words
A surface modified substrate according to claim 1, wherein there is ionically bonded to the adsorbed complex of polymeric cationic surfactant and dialdehyde, a polymeric anionic compound.
Claim 12
Dependent Claim
59 words
A surface modified substrate according to claim 10, wherein additional layers of the polymeric anionic compound are ionically bonded to the surface by means of intermediate ionically bonded layers of said complex of the polymeric cationic surfactant and the dialdehyde or the polymeric cationic surfactant alone, which contains primary amino nitrogens as well as secondary and/or tertiary amino nitrogens.
Claim 13
Dependent Claim
62 words
A surface modified substrate according to claim 1, wherein there is ionically bonded to the adsorbed complex of polymeric cationic surfactant and dialdehyde a polymeric anionic compound, and thereupon, ionically bonded as well, said complex of the polymeric cationic surfactant and the dialdehyde, or the polymeric cationic surfactant alone, which contains primary amino nitrogens as well as secondary and/or tertiary amino nitrogens.
Claim 14
Dependent Claim
32 words
A surface modified substrate according to, claims 10 or 12, wherein the polymeric anionic compound is a polysaccharide selected from the group consisting of heparin, dextran sulphate, hyaluronic acid and sulphated polyxylan.
Claim 15
Dependent Claim
15 words
A surface modified substrate according to claim 10, wherein the polymeric anionic compound is heparin.
Claim 16
Dependent Claim
16 words
A surface modified substrate according to claim 12, wherein the polymeric anionic compound is dextran sulphate.
Claim 17
Dependent Claim
21 words
A surface modified substrate according to claim 1, wherein there is bonded to said complex, via ionic binding, an anionic compound.
Claim 18
Dependent Claim
29 words
A surface modified substrate according to claim 1, wherein additional cationic and anionic compounds are alternatingly bonded to said complex, whereby the modified substrate is positively or negatively charged.
Claim 19
Independent Claim
76 words
A method of surface modifying a solid substrate by introducing ionic charges on the substrate surface, which comprises contacting the substrate with a polymeric cationic surfactant which contains primary amino nitrogens as well as secondary and/or tertiary amino nitrogens, and a dialdehyde which contains 1-4 carbon atoms between the two aldehyde groups, at such conditions that a complex of the polymeric cationic surfactant and the dialdehyde is formed, which complex is adsorbed to the substrate surface.
Claim 20
Independent Claim
76 words
A method of surface modifying a solid substrate by introducing ionic charges on the substrate surface, which comprises contacting the substrate with a polymeric cationic surfactant which contains primary amino nitrogens as well as secondary and/or tertiary amino nitrogens, and a dialdehyde which contains 1-4 carbon atoms between the two aldehyde groups, at such conditions that a complex of the polymeric cationic surfactant and the dialdehyde is formed, which complex is adsorbed to the substrate surface.
Claim 21
Dependent Claim
67 words
A method according to claim 18, which comprises performing the first contact with the substrate while using the polymeric cationic surfactant and the dialdehyde dissolved separately or together in a polar solvent, and at a pH-value higher than 8, the treatment being carried out with separate solutions in two steps or with a mixture in one step, and then making a rinsing operation with the polar solvent.
Claim 22
Dependent Claim
22 words
A method according to claim 19, which comprises choosing as the pH-value higher than 8 a value within the range of 8-12.
Claim 23
Dependent Claim
22 words
A method according to claim 18, wherein the polymeric cationic surfactant contains at least two primary amino groups in each polymer molecule.
Claim 24
Dependent Claim
21 words
A method according to claim 21, wherein the polymeric cationic surfactant is selected from the group consisting of polyimines and polyamides.
Claim 25
Independent Claim
16 words
A method according to claims 18 or 19, wherein the polymeric cationic surfactant is a polyalkyleneimine.
Claim 26
Dependent Claim
24 words
A method according to claim 18, wherein the polymeric cationic surfactant has 1-6 carbon atoms between the amino nitrogen atoms in the polymer molecule.
Claim 27
Independent Claim
16 words
A method according to claims 18 or 19, wherein the polymeric cationic surfactant is a polyethyleneimine.
Claim 28
Independent Claim
13 words
A method according to claims 18 or 19, wherein the dialdehyde is glutardialdehyde.
Claim 29
Independent Claim
35 words
A method according to claims 18, or 19, wherein the substrate is selected from the group consisting of stainless steel, glass or a polymeric material selected from polyvinylchloride, polyurethanes, silicon rubber, polytetrafluoroethylene, polystyrene and polyolefins.
Claim 30
Dependent Claim
34 words
A method according to claim 19, wherein the concentration of the solution with respect to the polymeric cationic surfactant is 0.0001-1, percent by weight, and with respect to the dialdehyde 0.01-2, percent by weight.
Claim 31
Dependent Claim
33 words
A method according to claim 28, which comprises adding NaCl to the solution of the anionic compound to make up for a final concentration of 0.01-1M, to increase the polarity of the solution.
Claim 32
Dependent Claim
30 words
A method according to claim 18, which comprises ionically bonding a polymeric anionic compound to the complex of the polymeric cationic surfactant and the dialdehyde adsorbed to the substrate surface.
Claim 33
Dependent Claim
58 words
A method according to claim 30, which comprises ionically bonding dextran sulphate to the complex of the polymeric cationic surfactant and the dialdehyde adsorbed to the substrate surface, and then ionically bonding the polymeric cationic surfactant at a pH of less than 7, and subsequently ionically bonding the polymeric anionic compound at a pH of less than 7.
Claim 34
Dependent Claim
58 words
A method according to claim 18, which comprises ionically bonding to the complex of the polymeric cationic surfactant and the dialdehyde, an anionic compound, to the surface, and subsequently performing additional ionic bonding, at a pH within the range of 2-10, with the polymeric cationic surfactant containing primary amino nitrogens as well as secondary and/or tertiary amino nitrogens.
Claim 35
Dependent Claim
29 words
A method according to claim 30, wherein the polysaccharide is selected from the polymeric anionic compound is a group consisting of heparin, dextran sulphate, hyaluronic acid and sulphated polyxylan.
Claim 36
Dependent Claim
13 words
A method according to claim 31, wherein the polymeric anionic compound is heparin.
Claim 37
Dependent Claim
19 words
A method according to claim 18, wherein an anionic compound is ionically bound to said complex exhibiting positive charges.
Claim 38
Dependent Claim
19 words
A method according to claim 19, wherein the polar solvent is adjusted to a pH of less than 7.
Claim 39
Dependent Claim
15 words
A method according to claim 36, wherein the pH is within the range of 1-7.
Claim 40
Dependent Claim
11 words
A method according to claim 27, wherein the substrate is polyethylene.
Claim 41
Dependent Claim
57 words
A method according to claim 30, wherein ionic bonding of the polymeric anionic compound is continued to make up additional layers, said complex of the polymeric cationic surfactant and the dialdehyde or solely the polymeric cationic surfactant that contains primary amino nitrogens as well as secondary and/or tertiary amino nitrogens being ionically bonded between the ionic layers.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-01-20 | 1989-07-22 | 1990-01-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-01-20 | 1993-07-22 | 1994-01-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-01-20 | 1997-07-22 | 1998-01-21 | $7700.00 | Window Closed / Lapsed |