Non-thrombogenic material

Claim 2

A non-thrombogenic material comprising an aldehyde group-containing polymer bonded directly with heparin in which at least one hydroxyl group of said heparin is covalently bonded to one aldehyde group of said polymer through only one acetal bond or hemiacetal bond at each bonding site between said heparin and said polymer.

Claim 3

The non-thrombogenic material according to claim 1 wherein said acetal or hemiacetal bond is formed by the reacting said heparin with said base polymer containing an aldehyde group or an aldehyde group forming group.

Claim 4

The non-thrombogenic material according to claim 2 wherein said base polymer is prepared by polymerizing or copolymerizing a vinyl monomer having an aldehyde group or an aldehyde group-forming group and/or a vinylidene monomer having an aldehyde group or an aldehyde group-forming group.

Claim 5

The non-thrombogenic material according to claim 2 wherein said base polymer is prepared by cleaving a carbon-carbon bond of a polymer, said bond joining two carbon atoms, each of which is bonded to a hydroxyl group.

Claim 6

The non-thrombogenic material according to claim 1 wherein said hemiacetal bond is converted to a more stable acetal bond by eliminating a water molecule or an alcohol molecule.

Claim 7

The non-thrombogenic material according to claim 2 wherein said aldehyde group of said base polymer is converted to an acetal or hemiacetal group in the presence of an alcohol and then reacted with said heparin.

Claim 8

The non-thrombogenic material according to claim 1 wherein said polymer contains aldehyde groups or aldehyde group-forming groups in the range of 1.0 to 20.0% by weight of said polymer, and said heparin is used as a solution having 50 to 100,000 USP units of heparin when applied to said reaction.

Claim 9

A non-thrombogenic material comprising a base polymer, said base polymer containing: (a) two vicinal carbon atoms, each containing a hydroxyl group; or (b) two hydroxyl-substituted carbon atoms with another carbon atom therebetween, said base polymer having been bonded directly with a heparin derivative containing aldehyde groups in which at least one aldehyde group of said heparin is covalently bonded to one hydroxyl group of said base polymer through only one acetal bond or hemiacetal bond at each bonding site between said heparin derivative and said base polymer.

Claim 10

A non-thrombogenic material comprising a base polymer, said base polymer containing: (a) two vicinal carbon atoms, each containing a hydroxyl group; or (b) two hydroxyl-substituted carbon atoms with another carbon atom therebetween, said base polymer having been bonded directly with a heparin derivative containing aldehyde groups in which at least one aldehyde group of said heparin is covalently bonded to one hydroxyl group of said base polymer through only one acetal bond or hemiacetal bond at each bonding site between said heparin derivative and said base polymer.

Claim 11

The non-thrombogenic material of claim 1 in which said aldehyde group is formed by cleaving a carbon-to-carbon bond of a vic-glycol type polymer with periodic acid, a salt of periodic acid or lead tetraacetate.

Claim 12

The non-thrombogenic material of claim 8 in which the aldehyde groups of the heparin are formed by cleaving carbon-to-carbon bonds of heparin with periodic acid, a salt of periodic acid or lead tetraacetate.

Claim 13

The non-thrombogenic material according to claim 8 wherein said heparin derivative containing aldehyde group is formed by cleaving a carbon-carbon bond of heparin having vicinal hydroxyl groups thereat.