US4350806A — Biocompatible copolymers

Claim 1

Independent Claim 205 words

A process for making articles which are compatible with biological materials, the improvement comprising forming said articles from a segmented thermoplastic copolyester consisting essentially of a multiplicity of recurring long-chain ester units and short-chain ester units joined head to tail through ester linkages, said long-chain ester units comprising from 30-70% by weight of the copolyester and being represented by the formula: ##STR8## and said short-chain ester units being represented by the formula: ##STR9## where L in said long-chain unit is a divalent radical remaining after removal of terminal hydroxyl groups from a poly(oxyalkylene) glycol having at least one thermally stable heterocyclic ring per molecule, each of said rings attached to said chain through amide or imide linkages and giving said radical, L, a carbon to nitrogen ratio between about 3/1 and about 350/1, and a number average molecular weight of between 200 and 8,000; R is a divalent radical remaining after removal of carboxyl groups from a dicarboxylic acid having a molecular weight of less than 300; and E in said short-chain unit is a divalent radical remaining after removal of hydroxyl groups from a low molecular weight diol having 2 to 15 carbon atoms per molecule and a molecular weight less than about 250.

Claim 2

Dependent Claim 205 words

A process for making articles which are compatible with biological materials, the improvement comprising forming said articles from a segmented thermoplastic copolyester consisting essentially of a multiplicity of recurring long-chain ester units and short-chain ester units joined head to tail through ester linkages, said long-chain ester units comprising from 30-70% by weight of the copolyester and being represented by the formula: ##STR8## and said short-chain ester units being represented by the formula: ##STR9## where L in said long-chain unit is a divalent radical remaining after removal of terminal hydroxyl groups from a poly(oxyalkylene) glycol having at least one thermally stable heterocyclic ring per molecule, each of said rings attached to said chain through amide or imide linkages and giving said radical, L, a carbon to nitrogen ratio between about 3/1 and about 350/1, and a number average molecular weight of between 200 and 8,000; R is a divalent radical remaining after removal of carboxyl groups from a dicarboxylic acid having a molecular weight of less than 300; and E in said short-chain unit is a divalent radical remaining after removal of hydroxyl groups from a low molecular weight diol having 2 to 15 carbon atoms per molecule and a molecular weight less than about 250.

Claim 3

Dependent Claim 16 words

The process of claim 1, wherein said heterocyclic ring is derived from a divalent hydantoin-containing monomer.

Claim 4

Dependent Claim 14 words

The process of claim 2, wherein said hydantoin-containing monomer has a chemically reactive site.

Claim 5

Dependent Claim 18 words

The process of claims 1, 2 or 3, wherein substantially all of the dicarboxylic acid is terephthalic acid.

Claim 6

Dependent Claim 19 words

The process of claims 1, 2 or 3, wherein substantially all the low molecular weight diol is 1,4-butane diol.

Claim 7

Dependent Claim 22 words

The process of claims 1, 2 or 3, wherein the poly(oxyalkylene) glycol is poly(oxethylene) glycol having a molecular weight of about 800-4000.

Claim 8

Dependent Claim 27 words

The process of claim 2, wherein said hydantoin-containing monomer has the structure: ##STR10## wherein R'=alkyl having 1-3 carbons, Hal=F, Cl, Br, I and R"=alkyl having 3-15 carbons.

Claim 9

Dependent Claim 20 words

The process of claims 3 or 7, wherein at least one heparin moiety is chemically attached to said reactive site.

Claim 10

Dependent Claim 199 words

A biocompatible article, adaptable for biomedical uses, said article being made from a segmented, thermoplastic copolyester consisting essentially of a multiplicity of recurring non-crystalline long-chain ester units and short-chain ester units joined head to tail through ester linkages, said long-chain ester units comprising from 30-70% by weight of the copolyester and being represented by the formula: ##STR11## and said short-chain ester units being represented by the formula ##STR12## where L in said long-chain unit is a divalent radical remaining after removal of terminal hydroxyl groups from a poly(oxyalkylene) glycol having at least one thermally stable heterocyclic ring per molecule, each of said rings attached to said chain through amide or imide linkages and giving said radical, L, a carbon to nitrogen ratio between about 3/1 and about 350/1, and a number average molecular weight of between 200 and 8,000; R is a divalent radical remaining after removal of carboxyl groups from dicarboxylic acid having a molecular weight of less than 300; and E in said short-chain unit is a divalent radical remaining after removal of hydroxyl groups from a low molecular weight diol having 2 to 15 carbon atoms per molecule and a molecular weight less than about 250.

Claim 11

Dependent Claim 199 words

A biocompatible article, adaptable for biomedical uses, said article being made from a segmented, thermoplastic copolyester consisting essentially of a multiplicity of recurring non-crystalline long-chain ester units and short-chain ester units joined head to tail through ester linkages, said long-chain ester units comprising from 30-70% by weight of the copolyester and being represented by the formula: ##STR11## and said short-chain ester units being represented by the formula ##STR12## where L in said long-chain unit is a divalent radical remaining after removal of terminal hydroxyl groups from a poly(oxyalkylene) glycol having at least one thermally stable heterocyclic ring per molecule, each of said rings attached to said chain through amide or imide linkages and giving said radical, L, a carbon to nitrogen ratio between about 3/1 and about 350/1, and a number average molecular weight of between 200 and 8,000; R is a divalent radical remaining after removal of carboxyl groups from dicarboxylic acid having a molecular weight of less than 300; and E in said short-chain unit is a divalent radical remaining after removal of hydroxyl groups from a low molecular weight diol having 2 to 15 carbon atoms per molecule and a molecular weight less than about 250.

Claim 12

Dependent Claim 21 words

The article of claim 9, wherein said heterocyclic ring is derived from a divalent hydantoin-containing monomer having a chemically reactive site.

Claim 13

Dependent Claim 23 words

The article of claim 10, wherein said hydantoin-containing monomer has the structure: ##STR13## wherein R'=alkyl having 1-3 carbons and R"=alkyl having 3-15 carbons.

Claim 14

Dependent Claim 20 words

The article of claim 11, wherein at least one heparin moiety is chemically attached to each of said reactive sites.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1985-09-20	1986-03-22	1986-09-21	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	1989-09-20	1990-03-22	1990-09-21	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	1993-09-20	1994-03-22	1994-09-21	$7700.00	Window Closed / Lapsed

Biocompatible copolymers

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