US6416548B2
Expired / Lapsed
US
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Antimicrobial annuloplasty ring having a biodegradable insert
Assignee: Corcym SRL
•
Filing: 1999-07-20
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Granted: 2002-07-09
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Expires: 2019-07-20
Abstract
Abstract This invention provides an antimicrobial annuloplasty rings, and methods for making the same, wherein the annuloplasty rings have a desired degree of initial rigidity to facilitate ease of handling during implantation but which becomes flexible some time after implantation. The annuloplasty ring contains a relatively rigid insert enclosed by a fabric sheath, the insert being at least partly comprised of a biodegradable material. Following surgical implantation of the annuloplasty ring, the rigid insert component of the ring, upon exposure to blood and/or other physiological fluids, undergoes a controlled biodegradation which decreases its rigidity, thereby increasing the flexibility of the implanted annuloplasty ring. Furthermore, at least some portion of the annuloplasty ring of the invention has incorporated therein one or more antimicrobial agents in a manner which reduces the likelihood of device infection following implantation.
Inventors
- 👤 Joseph A. Chinn
- 👤 R. Michael Casanova
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 23:37
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/02; A61F2/24; A61F2/2442; A61F2/2445; A61F2250/00; A61F2250/0058; A61F2250/0067; Y; Y10; Y10S; Y10S623/00; Y10S623/901
Claims Analysis
Total Claims: 30
Claim 1
Independent Claim
37 words
An annuloplasty ring comprising: a ring insert at least partly comprised of a surface eroding biodegradable polymer material; an elastomeric sheath enclosing said ring insert; and a fabric sheath enclosing said ring insert and said elastomeric sheath.
Claim 2
Dependent Claim
37 words
An annuloplasty ring comprising: a ring insert at least partly comprised of a surface eroding biodegradable polymer material; an elastomeric sheath enclosing said ring insert; and a fabric sheath enclosing said ring insert and said elastomeric sheath.
Claim 3
Dependent Claim
17 words
The annuloplasty ring of claim 1 , wherein the surface eroding biodegradable polymer material comprises a polyanhydride.
Claim 4
Dependent Claim
18 words
The annuloplasty ring of claim 1 , wherein the surface eroding biodegradable polymer material comprises a photopolymerizable polyanhydride.
Claim 5
Dependent Claim
22 words
The annuloplasty ring of claim 1 , wherein the surface eroding biodegradable polymer material comprises a polyanhydride polymerized from methacrylate anhydride monomers.
Claim 6
Dependent Claim
22 words
The annuloplasty ring of claim 4 , wherein the methacrylate anhydride monomers are synthesized from diacid molecules of sebacic acid or 1,6-bis(p-carboxyphenoxy)-hexane.
Claim 7
Dependent Claim
30 words
The annuloplasty ring of claim 4 , wherein the surface eroding biodegradable polymer material comprises a copolymer of methacrylate anhydride monomers synthesized from diacid molecules of sebacic acid and 1,6-bis(p-carboxyphenoxy)-hexane.
Claim 8
Dependent Claim
23 words
The annuloplasty ring of claim 1 , wherein the elastomeric sheath is comprised of a silicone rubber, a poly(ether urethane) or a polytetrafluoroethylene.
Claim 9
Dependent Claim
29 words
The annuloplasty ring of claim 1 , wherein the ring insert further comprises one or more plasticizers, stabilizers, pigments, dyes, radio-opaque materials, lubricants, antioxidants, bioactive agents or antithrombogenic agents.
Claim 10
Dependent Claim
66 words
The annuloplasty ring of claim 1 , wherein said annuloplasty ring further comprises at least one antimicrobial agent incorporated into the fabric sheath of the annuloplasty ring by dissolving the antimicrobial agent in a solvent to form an antimicrobial solution consisting of said antimicrobial agent and said solvent and contacting the antimicrobial solution with at least some portion of the fabric sheath of the annuloplasty ring.
Claim 11
Dependent Claim
26 words
The annuloplasty ring of claim 9 , wherein said solvent is selected from the group consisting of alcohols, ethers, aldehydes, acetonitrile, acetic acid, and aprotic heterocyclics.
Claim 12
Dependent Claim
21 words
The method of claim 9 , wherein said solvent is selected from the group consisting of methanol, ethanol, or n-methyl pyrrolidinone.
Claim 13
Dependent Claim
17 words
The annuloplasty ring of claim 9 , wherein the fabric sheath is comprised of a polymeric material.
Claim 14
Dependent Claim
28 words
The annuloplasty ring of claim 9 , wherein the fabric sheath is comprised of a polymeric material selected from the group consisting of polyethyleneterephthalate, polytetrafluoroethylene and polyester (polyacetate).
Claim 15
Independent Claim
54 words
A method for making an annuloplasty ring comprising: forming a ring insert at least partly comprised of a surface eroding biodegradable polymer material; enclosing at least a portion of said ring insert in an elastomeric sheath and enclosing at least a portion of said ring insert and said elastometeric sheath within a fabric sheah.
Claim 16
Independent Claim
54 words
A method for making an annuloplasty ring comprising: forming a ring insert at least partly comprised of a surface eroding biodegradable polymer material; enclosing at least a portion of said ring insert in an elastomeric sheath and enclosing at least a portion of said ring insert and said elastometeric sheath within a fabric sheah.
Claim 17
Dependent Claim
16 words
The method of claim 14 , wherein the surface eroding biodegradable polymer material comprises a oilyanhydride.
Claim 18
Dependent Claim
55 words
The method of claim 14 , further comprising dissolving at least one antimicrobial agent in a solvent to form an antimicrobial solution; contacting the antimicrobial solution with at least some portion of the fabric sheath of the annuloplasty ring; and evaporating said solvent to deposit said at least one antimicrobial agent in said fabric sheath.
Claim 19
Dependent Claim
25 words
The method of claim 16 , wherein the solvent is selected from the group consisting of alcohols, ethers, aldehydes, acetonitrile, acetic acid, and aprotic heterocyclics.
Claim 20
Dependent Claim
21 words
The method of claim 16 , wherein the solvent is selected from the group consisting of methanol, ethanol, or n-methyl pyrrolidinone.
Claim 21
Dependent Claim
23 words
The method of claim 14 , wherein the ring insert is formed by molding, extrusion or machining the surface eroding biodegradable polymer material.
Claim 22
Dependent Claim
17 words
The method of claim 14 , wherein the surface eroding biodegradable polymer material comprises a photopolymerizable polyanhydride.
Claim 23
Dependent Claim
21 words
The method of claim 14 , wherein the surface eroding biodegradable polymer material comprises a polyanhydride polymerized from methacrylate anhydride monomers.
Claim 24
Dependent Claim
21 words
The method of claim 21 , wherein the methacrylate anhydride monomers are synthesized from diacid molecules of sebacic acid or 1,6-bis(p-carboxyphenoxy)-hexane.
Claim 25
Dependent Claim
26 words
The method of claim 21 , wherein the biodegradable material comprises a copolymer of methacrylate anhydride monomers synthesized from diacid molecules of sebacic acid and 1,6-bis(p-carboxyphenoxy)-hexane.
Claim 26
Dependent Claim
16 words
The method of claim 16 , wherein the fabric sheath is comprised of a polymeric material.
Claim 27
Dependent Claim
27 words
The method of claim 16 , wherein the fabric sheath is comprised of a polymeric material selected from the group consisting of polyethyleneterephthalate, polytetrafluoroethylene and polyester (polyacetate).
Claim 28
Dependent Claim
22 words
The method of claim 14 , wherein the elastomeric sheath is comprised of a silicone rubber, a poly(ether urethane) or a polytetrafluoroethylene.
Claim 29
Dependent Claim
28 words
The method of claim 14 , wherein the ring insert further comprises one or more plasticizers, stabilizers, pigments, dyes, radio-opaque materials, lubricants, antioxidants, bioactive agents or antithrombogenic agents.
Claim 30
Dependent Claim
12 words
An annuloplasty ring produced according to the method of claim 14 .
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