US6352708B1
Expired / Lapsed
US
⏱️ 0.0 years remaining
Solution and method for treating autologous tissue for implant operation
Assignee: International Heart Institute of Montana Foundation
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Filing: 1999-10-14
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Granted: 2002-03-05
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Expires: 2019-10-14
Abstract
Abstract An aqueous solution containing a water miscible organic solvent, polyethylene glycol and heparine, is used to modify the tissue reactivity of an autologous tissue freshly obtained from a host mammal and to render the tissue temporarily more rigid than in its native state, and better suited for shaping, molding, handling and cutting prior to implantation into the host patient. The implant is highly resistant or immune to thickening, contraction and reduced fibrin deposition after it is implanted and exposed to the bloodstream of the host.
Inventors
- 👤 Carlos M. G. Duran
- 👤 David T. Cheung
- 👤 David C. Pang
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:52
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3683; A61L27/3687; A61F; A61F2/00; A61F2/02; A61F2/24; A61F2/2412; A61F2/2415; A61L27/3604; A61L2430/00; A61L2430/40
Claims Analysis
Total Claims: 28
Claim 1
Independent Claim
102 words
An aqueous composition adapted for treating autologous biological tissue for modifying its tissue reactivity and for rendering the tissue temporarily more rigid than in its natural state, the composition comprising: approximately 10 to 70% by volume of a water miscible non-toxic organic solvent selected from the group consisting of an alcohol having 1 to 3 carbons, acetone, acetonitrile and methyl ethyl ketone; approximately 2 to 30% by weight of polyethylene glycol having a molecular weight in the range of approximately 6,000 to 15,000 D; approximately 0.01 to 1.0% by weight of heparin, and the balance of the composition substantially consisting of water.
Claim 2
Dependent Claim
102 words
An aqueous composition adapted for treating autologous biological tissue for modifying its tissue reactivity and for rendering the tissue temporarily more rigid than in its natural state, the composition comprising: approximately 10 to 70% by volume of a water miscible non-toxic organic solvent selected from the group consisting of an alcohol having 1 to 3 carbons, acetone, acetonitrile and methyl ethyl ketone; approximately 2 to 30% by weight of polyethylene glycol having a molecular weight in the range of approximately 6,000 to 15,000 D; approximately 0.01 to 1.0% by weight of heparin, and the balance of the composition substantially consisting of water.
Claim 3
Dependent Claim
15 words
The liquid composition of claim 1 wherein the water miscible organic solvent is ethyl alcohol.
Claim 4
Dependent Claim
14 words
The liquid composition of claim 2 that contains approximately 15 to 60% ethyl alcohol.
Claim 5
Dependent Claim
12 words
The liquid composition of claim 3 that contains approximately 50% ethyl alcohol.
Claim 6
Dependent Claim
14 words
The liquid composition of claim 1 that contains approximately 2 to 10% polyethylene glycol.
Claim 7
Dependent Claim
12 words
The liquid composition of claim 5 that contains approximately 5% polyethylene glycol.
Claim 8
Dependent Claim
18 words
The liquid composition of claim 5 wherein the polyethylene glycol has a molecular weight of approximately 8,000 D.
Claim 9
Dependent Claim
13 words
The liquid composition of claim 1 that contains approximately 0.1 to 0.7% heparin.
Claim 10
Dependent Claim
11 words
The liquid composition of claim 8 that contains approximately 0.5% heparin.
Claim 11
Dependent Claim
75 words
An aqueous liquid composition adapted for treating autologous biological tissue for modifying its tissue reactivity and for rendering the tissue temporarily more rigid than in its natural state, the composition comprising: approximately 15 to 60% by volume of ethyl alcohol; approximately 2 to 10% by weight of polyethylene glycol of a molecular weight of approximately 8,000 D; approximately 0.1 to 0.7% by weight of heparine, and the balance of the composition substantially consisting of water.
Claim 12
Dependent Claim
75 words
An aqueous liquid composition adapted for treating autologous biological tissue for modifying its tissue reactivity and for rendering the tissue temporarily more rigid than in its natural state, the composition comprising: approximately 15 to 60% by volume of ethyl alcohol; approximately 2 to 10% by weight of polyethylene glycol of a molecular weight of approximately 8,000 D; approximately 0.1 to 0.7% by weight of heparine, and the balance of the composition substantially consisting of water.
Claim 13
Dependent Claim
19 words
The liquid composition of claim 10 comprising approximately 50% ethyl alcohol, approximately 5% polyethylene glycol and approximately 0.5% heparine.
Claim 14
Independent Claim
114 words
A method for modifying the tissue reactivity of an autologous tissue freshly obtained from a host mammal and for rendering the tissue temporarily more rigid than in its native state, the method comprising: exposing said autologous tissue to an aqueous composition, comprising: approximately 10 to 70% by volume of a water miscible non-toxic organic solvent selected from the group consisting of an alcohol having 1 to 3 carbons, acetone, acetonitrile and methyl ethyl ketone; approximately 2 to 30% by weight of polyethylene glycol having a molecular weight in the range of approximately 6,000 to 15,000 D; approximately 0.01 to 1.0% by weight of heparin, and the balance of the composition substantially consisting of water.
Claim 15
Independent Claim
114 words
A method for modifying the tissue reactivity of an autologous tissue freshly obtained from a host mammal and for rendering the tissue temporarily more rigid than in its native state, the method comprising: exposing said autologous tissue to an aqueous composition, comprising: approximately 10 to 70% by volume of a water miscible non-toxic organic solvent selected from the group consisting of an alcohol having 1 to 3 carbons, acetone, acetonitrile and methyl ethyl ketone; approximately 2 to 30% by weight of polyethylene glycol having a molecular weight in the range of approximately 6,000 to 15,000 D; approximately 0.01 to 1.0% by weight of heparin, and the balance of the composition substantially consisting of water.
Claim 16
Dependent Claim
18 words
The method of claim 12 where in the liquid composition the water miscible organic solvent is ethyl alcohol.
Claim 17
Dependent Claim
16 words
The method of claim 13 where the liquid composition contains approximately 15 to 60% ethyl alcohol.
Claim 18
Dependent Claim
16 words
The method of claim 13 where the liquid composition contains approximately 2 to 10% polyethylene glycol.
Claim 19
Dependent Claim
15 words
The method of claim 13 where the liquid composition contains approximately 0.1 to 0.7% heparin.
Claim 20
Dependent Claim
30 words
The method of claim 13 where the liquid composition contains approximately 50% ethyl alcohol, approximately 5% polyethylene glycol of a molecular weight of approximately 8,000 D and approximately 0.5% heparin.
Claim 21
Dependent Claim
19 words
The method of claim 12 where the autologous tissue freshly obtained from a host mammal comprises a biological membrane.
Claim 22
Dependent Claim
21 words
The method of claim 12 where the autologous tissue is selected from a group consisting of peritoneum, pericardium, pleura and tendon.
Claim 23
Dependent Claim
26 words
The method of claim 12 wherein the step of exposing the autologous tissue to the liquid composition is by immersing the tissue in the liquid composition.
Claim 24
Dependent Claim
17 words
The method of claim 20 further comprising the step of placing the autologous tissue in a mold.
Claim 25
Dependent Claim
48 words
The method of claim 21 wherein the autologous tissue is placed in the mold before the tissue is exposed to the liquid composition, and wherein the tissue is exposed to the liquid composition while it is held in said mold, thereby forming said tissue into a predetermined configuration.
Claim 26
Dependent Claim
42 words
The method of claim 22 further comprising the step of trimming excess autologous tissue by cutting while said tissue is still in the mold and after it has been exposed to said liquid composition for at least approximately 2 to 8 minutes.
Claim 27
Dependent Claim
17 words
The method of claim 23 further comprising the step of implanting the trimmed tissue into the host.
Claim 28
Dependent Claim
33 words
The method of claim 24 further comprising the step of irrigating the implanted tissue with isotonic saline solution thereby causing the physical properties of the tissue to return to their substantially native state.
References Cited (Backward Citations)
US2106261A
Cited
US2610625A
Cited
US2645618A
Cited
GB716161A
Cited
US2659986A
Cited
US3939260A
Cited
US4280954A
Cited
US4329492A
Cited
US4277238A
Cited
US4300243A
Cited
US4383832A
Cited
US4323358A
Cited
US4357274A
Cited
US4578067A
Cited
US4704131A
Cited
US4801299A
Cited
US4703108A
Cited
US5028597A
Cited
US4760131A
Cited
US4911915A
Cited
US5276006A
Cited
US5131850A
Cited
US5116552A
Cited
US5336616A
Cited
US5296514A
Cited
US5476517A
Cited
US5518878A
Cited
US5558875A
Cited
US5931969A
Cited
US5674290A
Cited
US5863984A
Cited
WO1997032472A1
Cited
WO1998007452A1
Cited
WO1999066967A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2005-03-04 | 2005-09-03 | 2006-03-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2009-03-04 | 2009-09-03 | 2010-03-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2013-03-04 | 2013-09-03 | 2014-03-05 | $7700.00 | Window Closed / Lapsed |