US4323358A
Expired / Lapsed
US
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Method for inhibiting mineralization of natural tissue during implantation
Assignee: Medtronic Inc
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Filing: 1981-04-30
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Granted: 1982-04-06
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Expires: 2001-04-30
Abstract
Abstract Natural tissues fixed with a tanning solution such as glutaraldehyde and intended for implantation in humans, e.g., porcine heart valve prosthetic devices, are treated with a solution of a water soluble salt of a sulfated higher aliphatic alcohol such as sodium dodecyl sulfate to inhibit mineralization, particularly calcification, of the tissue after implantation.
Inventors
- 👤 David J. Lentz
- 👤 Elisabeth M. Pollock
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 17:34
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3683; A61L27/3687; A61F; A61F2/00; A61F2/02; A61F2/24; A61F2/2412; A61L2400/00; A61L2400/02; Y; Y10; Y10S; Y10S623/00; Y10S623/915; Y10S623/916
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
39 words
A method for inhibiting the mineralization of fixed natural tissue after implantation in a living body comprising contacting fixed natural tissue intended for implantation with an aqueous solution of a water soluble salt of a C 7-18 alkyl sulfate.
Claim 2
Independent Claim
39 words
A method for inhibiting the mineralization of fixed natural tissue after implantation in a living body comprising contacting fixed natural tissue intended for implantation with an aqueous solution of a water soluble salt of a C 7-18 alkyl sulfate.
Claim 3
Dependent Claim
18 words
The method of claim 1 wherein the aqueous solution is buffered to a pH of 4.0 to 9.0.
Claim 4
Dependent Claim
23 words
The method of claim 1 wherein the water soluble salt is selected from the group consisting of sodium, potassium, ammonium and amine salts.
Claim 5
Dependent Claim
16 words
The method of claim 1 wherein the C 7-18 alkyl is a straight chain aliphatic group.
Claim 6
Dependent Claim
14 words
The method of claim 1 wherein C 7-18 alkyl is a branched aliphatic group.
Claim 7
Dependent Claim
24 words
The method of claim 1 wherein C 7-18 alkyl sulfate is selected from the group consisting of lauryl, myristyl, cetyl, steryl and oleyl sulfate.
Claim 8
Dependent Claim
33 words
The method of claim 1 wherein said natural tissue is contacted with said salt of C 7-18 alkyl sulfate for a time sufficient to effectively inhibit future calcification of said tissue after implantation.
Claim 9
Dependent Claim
29 words
The method of claim 7 wherein said tissue is contacted with said salt of C 7-18 alkyl sulfate for a period of at least 4 hours at room temperature.
Claim 10
Dependent Claim
27 words
The method of claim 1 wherein the concentration of said salt of C 7-18 alkyl sulfate in said solution is from about 0.1 to 5% by weight.
Claim 11
Dependent Claim
17 words
The method of claim 9 wherein the solution is buffered to a pH of 7.0 to 7.5.
Claim 12
Independent Claim
45 words
A method for inhibiting the calcification of fixed natural tissue after implantation in a living body which comprises contacting fixed tissue intended for implantation with a solution comprising sodium dodecyl sulfate for a time sufficient to effectively inhibit future calcification of said tissue after implantation.
Claim 13
Independent Claim
45 words
A method for inhibiting the calcification of fixed natural tissue after implantation in a living body which comprises contacting fixed tissue intended for implantation with a solution comprising sodium dodecyl sulfate for a time sufficient to effectively inhibit future calcification of said tissue after implantation.
Claim 14
Dependent Claim
19 words
The method of claim 11 wherein said solution comprises from about 0.1 to 5% by weight sodium dodecyl sulfate.
Claim 15
Dependent Claim
22 words
The method of claim 11 wherein said tissue is contacted with said solution for a time of at least about 4 hours.
Claim 16
Dependent Claim
19 words
The method of claim 11 wherein said solution is buffered to a pH of from about 7.0 to 7.5.
Claim 17
Dependent Claim
22 words
The method of claim 11 wherein the solution is buffered to a pH of about 7.4 with about 0.005 M N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid.
Claim 18
Dependent Claim
15 words
The method of claim 15 wherein the concentration of sodium dodecyl sulfate is about 1%.
Claim 19
Dependent Claim
27 words
The method of claim 16 wherein the tissue is contacted with said solution of sodium dodecyl sulfate for a period of about 24 hours at ambient temperature.
Claim 20
Dependent Claim
15 words
The method of claim 11 wherein the fixed tissue is a glutaraldehyde-fixed porcine heart valve.
Claim 21
Dependent Claim
12 words
The method of claim 11 wherein said living body is a human.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-04-05 | 1985-10-05 | 1986-04-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-04-05 | 1989-10-05 | 1990-04-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-04-05 | 1993-10-05 | 1994-04-06 | $7700.00 | Window Closed / Lapsed |