US4578067A
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US
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Hemostatic-adhesive, collagen dressing for severed biological surfaces
Assignee: Alcon Puerto Rico Inc
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Filing: 1985-03-04
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Granted: 1986-03-25
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Expires: 2005-03-04
Abstract
Abstract Hemostatic-adhesive, collagen dressings in the form of dry-laid, non-woven, self-supporting webs of collagen fibers and methods for preparing those webs are disclosed. The webs are formed from a mass of hemostatic-adhesive, collagen fibers having a moisture content of from about 7% to about 15% by weight, and retain the hemostatic-adhesive properties of the mass of collagen fibers.
Inventors
- 👤 Mamerto M. Cruz, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 04:57
CPC Classifications
A; A61; A61L; A61L15/00; A61L15/16; A61L15/22; A61L15/32; A61L15/325; A61L2400/00; A61L2400/04; Y; Y10; Y10S; Y10S128/00; Y10S128/08
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
74 words
A hemostatic-adhesive, collagen dressing for severed biological surfaces, comprising a dry-laid, non-woven, self-supporting web formed from a mass of hemostatic-adhesive, collagen fibers having a moisture content of from about 7% to about 15% by weight, said collagen fibers consisting essentially of an ionizable, water insoluble, partial acid salt of collagen containing from about 50% to about 90% of the theoretical stoichiometric amount of ionizable acid, said web having been calendered to improve its integrity.
Claim 2
Dependent Claim
74 words
A hemostatic-adhesive, collagen dressing for severed biological surfaces, comprising a dry-laid, non-woven, self-supporting web formed from a mass of hemostatic-adhesive, collagen fibers having a moisture content of from about 7% to about 15% by weight, said collagen fibers consisting essentially of an ionizable, water insoluble, partial acid salt of collagen containing from about 50% to about 90% of the theoretical stoichiometric amount of ionizable acid, said web having been calendered to improve its integrity.
Claim 3
Dependent Claim
23 words
A hemostatic-adhesive, collagen dressing according to claim 1, wherein the hemostatic-adhesive properties of the mass of collagen fibers are retained by the web.
Claim 4
Dependent Claim
42 words
A hemostatic-adhesive, collagen dressing according to claim 1, wherein the partial acid salt of collagen consists essentially of an ionizable, water insoluble, partial acid salt of collagen containing from about 60% to about 85% of the theoretical stoichiometric amount of ionizable acid.
Claim 5
Dependent Claim
25 words
A hemostatic-adhesive, collagen dressing according to claim 1, wherein the partial acid salt of collagen consists essentially of a partial hydrogen chloride salt of collagen.
Claim 6
Dependent Claim
25 words
A hemostatic-adhesive, collagen dressing according to claim 3, wherein the partial acid salt of collagen consists essentially of a partial hydrogen chloride salt of collagen.
Claim 7
Dependent Claim
36 words
A hemostatic-adhesive, collagen dressing according to claim 1, wherein the partial acid salt of collagen consists essentially of a partial hydrogen chloride salt of collagen containing about 84% of the theoretical stoichiometric amount of hydrogen chloride.
Claim 8
Dependent Claim
35 words
A hemostatic-adhesive, collagen dressing according to claim 1, wherein the web has a basis weight of from about 200 to about 400 grams per square meter and a thickness of about 1 to 2 millimeters.
Claim 9
Independent Claim
103 words
A method of preparing a hemostatic-adhesive, collagen dressing for severed biological surfaces in the form of a dry-laid, non-woven, self-supporting web of collagen fibers which comprises supplying a mass of hemostatic-adhesive, collagen fibers having a moisture content of from about 7% to about 15% by weight to conventional air-laying web forming equipment to convert the mass of fibers into a dry-laid, non-woven web, said collagen fibers consisting essentially of an ionizable, water insoluble, partial acid salt of collagen containing from about 50% to about 90% of the theoretical stoichiometric amount of ionizable acid, and calendering the web to provide a self-supporting web structure.
Claim 10
Independent Claim
103 words
A method of preparing a hemostatic-adhesive, collagen dressing for severed biological surfaces in the form of a dry-laid, non-woven, self-supporting web of collagen fibers which comprises supplying a mass of hemostatic-adhesive, collagen fibers having a moisture content of from about 7% to about 15% by weight to conventional air-laying web forming equipment to convert the mass of fibers into a dry-laid, non-woven web, said collagen fibers consisting essentially of an ionizable, water insoluble, partial acid salt of collagen containing from about 50% to about 90% of the theoretical stoichiometric amount of ionizable acid, and calendering the web to provide a self-supporting web structure.
Claim 11
Dependent Claim
30 words
A method of forming a dry-laid, non-woven web of collagen fibers according to claim 8, wherein the hemostatic-adhesive properties of the mass of collagen fibers are retained by the web.
Claim 12
Dependent Claim
50 words
A method of preparing a dry-laid, non-woven, self-supporting web of collagen fibers according to claim 8, wherein the partial acid salt of collagen consists essentially of an ionizable, water insoluble, partial acid salt of collagen containing from about 60% to about 85% of the theoretical stoichiometric amount of ionizable acid.
Claim 13
Dependent Claim
33 words
A method of preparing a dry-laid, non-woven, self-supporting web of collagen fibers according to claim 8, wherein the partial acid salt of collagen consists essentially of a partial hydrogen chloride salt of collagen.
Claim 14
Dependent Claim
34 words
A method of preparing a dry-laid, non-woven, self-supporting web of collagen fibers according to claim 8, wherein the web has a moisture content of from about 5% to about 15% by weight when calendered.
Claim 15
Dependent Claim
43 words
A method of preparing a dry-laid, non-woven, self-supporting web of collagen fibers according to claim 8, wherein the web has a moisture content of from about 7% to about 12% by weight when calendered and is calendered by the use of plain rolls.
Claim 16
Dependent Claim
43 words
A method of preparing a dry-laid, non-woven, self-supporting web of collagen fibers according to claim 8, wherein the web has a moisture content of from about 5% to about 12% by weight when calendered and is calendered by the use of embossing rolls.
Claim 17
Dependent Claim
61 words
A method of preparing a dry-laid, non-woven, self-supporting web of collagen fibers according to claim 8, wherein the air circulating in the air-laying web forming equipment and the ambient atmosphere surrounding that equipment are maintained at a temperature of 21° to 24° C. and a relative humidity of 50 to 55% when the mass of hemostatic-adhesive collagen fibers is supplied thereto.
Claim 18
Dependent Claim
70 words
A hemostatic-adhesive, collagen dressing for severed biological surfaces, comprising a dry-laid, non-woven, self-supporting web formed from a mass of hemostatic-adhesive, collagen fibers having a moisture content of 8% to 11% by weight, said collagen fibers consisting essentially of an ionizable, water insoluble, partial acid salt of collagen containing from about 60% to 85% of the theoretical stoichiometric amount of ionizable acid, said web having been calendered to improve its integrity.
Claim 19
Dependent Claim
70 words
A hemostatic-adhesive, collagen dressing for severed biological surfaces, comprising a dry-laid, non-woven, self-supporting web formed from a mass of hemostatic-adhesive, collagen fibers having a moisture content of 8% to 11% by weight, said collagen fibers consisting essentially of an ionizable, water insoluble, partial acid salt of collagen containing from about 60% to 85% of the theoretical stoichiometric amount of ionizable acid, said web having been calendered to improve its integrity.
Claim 20
Dependent Claim
25 words
A hemostatic-adhesive, collagen dressing according to claim 16, wherein the partial acid salt of collagen consists essentially of a partial hydrogen chloride salt of collagen.
Claim 21
Dependent Claim
36 words
A hemostatic-adhesive, collagen dressing according to claim 16, wherein the partial acid salt of collagen consists essentially of a partial hydrogen chloride salt of collagen containing about 84% of the theoretical stoichiometric amount of hydrogen chloride.
Claim 22
Dependent Claim
34 words
A hemostatic-adhesive, collagen dressing according to claim 16, wherein the web has basis weight of from about 200 to about 400 grams per square meter and a thickness of about 1 to 2 millimeters.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1989-03-24 | 1989-09-23 | 1990-03-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-03-24 | 1993-09-23 | 1994-03-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-03-24 | 1997-09-23 | 1998-03-25 | $7700.00 | Window Closed / Lapsed |