Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
40 words
A biomaterial of a stable porosity which comprises a porous biopolymer matrix into which is impregnated and conjugated a polyethylene molecule having a substituted ether end, which is conjugated to said biopolymer through a reactive group present on said biopolymer.
Claim 2
Dependent Claim
40 words
A biomaterial of a stable porosity which comprises a porous biopolymer matrix into which is impregnated and conjugated a polyethylene molecule having a substituted ether end, which is conjugated to said biopolymer through a reactive group present on said biopolymer.
Claim 3
Dependent Claim
277 words
A biomaterial as defined in claim 1 wherein said polyethylene molecule has the following formula: A--O--(CH.sub.2 --CH.sub.2 --O).sub.m --(CH.sub.2).sub.n --Z wherein: m is an integer comprised between 2 and 500; n is an integer comprised between 1 and 7; A is a substituent represented as a moiety prior to its linkage at its left end to said reactive group of said biopolymer, said moiety being selected from the group consisting of: B--CR═CH--, wherein R is hydrogen or a lower alkyl, and B is hydrogen, carboxy, hydroxy, aldehyde, NH 2 -- or SH--; cyanuric chloride or hydrogen cyanide; 2 OS--X--CH 2 --, wherein X is absent or a linear, branched or aromatic group of 1 to 6 carbon atoms; D--OOC--(CH 2 ) o --, wherein o is an integer comprised between 1 to 7, and D is, hydrogen, an anhydride, a mixed anhydride or an activated ester of 1 to 8 carbon atoms; --N--(CH 2 ) o --, wherein o is an integer comprised between 1 to 7; --S--(CH 2 ) o , wherein o is an integer comprised between 1 to 7; --Z is selected from the group consisting of: hydrogen; --FGE wherein F is O - , N - or S - , G is hydrogen, a lower alkyl, a cycloalkyl of 1 to 7 carbon atoms or --C(O)--I, wherein I is a reactive group of a pharmaceutical agent, and E is absent hydrogen or a lower alkyl; and --C(O)--JE, wherein J is hydrogen, a lower alkyl, a cycloalkyl of 1 to 7 carbon atoms or --O--K, wherein K is a reactive group of a pharmaceutical agent, and E is absent hydrogen or a lower alkyl.
Claim 4
Dependent Claim
28 words
A material according to claim 1 wherein said biopolymer is selected from collagen, crosslinked gelatin, fibronectin, larninin, vitronectin, fibrinogen/fibrin, glycosaminoglycans, Matrigel™ basement membrane matrix, cellulose, chitosan and chitin.
Claim 5
Dependent Claim
25 words
A material according to claim 2 wherein said biopolymer is selected from collagen, crosslinked gelatin, fibronectin, laminin, vitronectin, fibrinogen/fibrin, glycosaminoglycans, Matrigel™ cellulose, chitosan and chitin.
Claim 6
Dependent Claim
11 words
A material according to claim 3 wherein said biopolymer is collagen.
Claim 7
Dependent Claim
11 words
A material according to claim 4 wherein said biopolymer is collagen.
Claim 8
Dependent Claim
13 words
A material according to claim 5 wherein said biopolymer is type I collagen.
Claim 9
Dependent Claim
13 words
A material according to claim 6 wherein said biopolymer is type I collagen.
Claim 10
Dependent Claim
12 words
A material according to claim 2 wherein A is acrylate or methacrylate.
Claim 11
Dependent Claim
12 words
A material according to claim 3 wherein A is acrylate or methacrylate.
Claim 12
Dependent Claim
12 words
A material according to claim 6 wherein A is acrylate or methacrylate.
Claim 13
Dependent Claim
17 words
A material according to claim 9, 10 or 11, wherein said conjugation is performed by gamma radiation.
Claim 14
Dependent Claim
14 words
A material according to claim 2 wherein said pharmaceutical agent is a growth factor.
Claim 15
Dependent Claim
36 words
A material according to claim 13 wherein said growth factor is selected from the group consisting of: FGF, EGF, TGF, PDGF, TNF, IGF, CSF, NGF, heparin binding growth factor, interferons, erythropoeitin, interleukins and tissue activating peptides.
Claim 16
Dependent Claim
30 words
A material according to claim 2, 4 or 6 wherein A is cyanuric chloride, m is an integer comprised between 7 to 45, n is 1 and Z is hydrogen.
Claim 17
Dependent Claim
38 words
A material according to claim 2, 4 or 6 wherein A is D--O(O)C--(CH 2 ) 3-5 wherein D is hydrogen, or succinimidyl, m is an integer comprised between 7 to 45, n is 1 and Z is hydrogen.