US4300243A
Expired / Lapsed
US
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Process for the preparation of preserved transplants
Assignee: BLODYNAMICS INTERNATIONAL (DEUTSCHLAND) GmbH
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Filing: 1980-02-08
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Granted: 1981-11-17
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Expires: 2000-02-08
Abstract
Abstract Biological collagenous material is preserved by dehydrating utilizing an organic water-miscible solvent.
Inventors
- 👤 Ludwig Baumgartner
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 02:43
CPC Classifications
A; A01; A01N; A01N1/00; A01N1/10; A01N1/12; A01N1/122; A01N1/125; A61; A61F; A61F2/00; A61F2/02; A61F2/04; A61F2/06; A61F2/08; A61F2/10; A61F2/105; A61F2/30; A61F2/30756; A61F2/3094; A61F2/28; A61F2002/2835; A61F2310/00; A61F2310/00005; A61F2310/00365; Y; Y10; Y10S; Y10S128/00; Y10S128/08; Y10S623/00; Y10S623/915; Y10S623/916; Y10S623/917
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
66 words
A process for the preparation of biological collagenous material for use as a transplant comprises contacting said material in a continuous manner with fresh amounts of a water-miscible organic solvent selected from the group consisting of methanol, ethanol, propanol, isopropanol, acetone, methylethylketone and mixtures thereof so as to dehydrate said material, and subsequently removing said solvent at a pressure of between 0.1 bar to 1.0 bar.
Claim 2
Dependent Claim
66 words
A process for the preparation of biological collagenous material for use as a transplant comprises contacting said material in a continuous manner with fresh amounts of a water-miscible organic solvent selected from the group consisting of methanol, ethanol, propanol, isopropanol, acetone, methylethylketone and mixtures thereof so as to dehydrate said material, and subsequently removing said solvent at a pressure of between 0.1 bar to 1.0 bar.
Claim 3
Dependent Claim
16 words
A process according to claim 1, comprising effecting said dehydration in from 2 to 24 hours.
Claim 4
Dependent Claim
16 words
A process according to claim 2, comprising effecting said dehydration in from 5 to 12 hours.
Claim 5
Dependent Claim
25 words
A process according to claim 1, wherein after contacting said material with said solvent, said solvent is removed at a pressure of about 0.5 bar.
Claim 6
Dependent Claim
28 words
A process according to claim 1, wherein after contacting said material with said solvent, said solvent is removed at a temperature of from 10 to 50 degrees centigrade.
Claim 7
Dependent Claim
16 words
A process according to claim 5, wherein said solvent is removed at about 37 degrees centigrade.
Claim 8
Independent Claim
60 words
A method of preserving material suitable for use as a human transplant comprising contacting dura mater with fresh amounts of water-miscible organic solvent selected from the group consisting of methanol, ethanol, propanol, isopropanol, acetone, methyl-ethylketone and mixtures thereof so as to dehydrate said dura mater, and subsequently removing said solvent at a pressure of between 0.1 bar and 1.0 bar.
Claim 9
Independent Claim
60 words
A method of preserving material suitable for use as a human transplant comprising contacting dura mater with fresh amounts of water-miscible organic solvent selected from the group consisting of methanol, ethanol, propanol, isopropanol, acetone, methyl-ethylketone and mixtures thereof so as to dehydrate said dura mater, and subsequently removing said solvent at a pressure of between 0.1 bar and 1.0 bar.
Claim 10
Dependent Claim
66 words
Dura mater which has been preserved for use as a human transplant by contacting said dura mater in a continuous manner with fresh amounts of a water-miscible organic solvent selected from the group consisting of methanol, ethanol, propanol, isopropanol, acetone, methylethylketone and mixtures thereof so as to dehydrate said dura mater, and subsequently removing said solvent at a pressure of between 0.1 bar and 1.0 bar.
Claim 11
Dependent Claim
66 words
Dura mater which has been preserved for use as a human transplant by contacting said dura mater in a continuous manner with fresh amounts of a water-miscible organic solvent selected from the group consisting of methanol, ethanol, propanol, isopropanol, acetone, methylethylketone and mixtures thereof so as to dehydrate said dura mater, and subsequently removing said solvent at a pressure of between 0.1 bar and 1.0 bar.
Claim 12
Independent Claim
85 words
A method of preserving material suitable for use as a human transplant comprising contacting a biological collagenous material without subdivision thereof at ambient temperatures in the absence of added water with fresh amounts of water-miscible organic solvent selected from the group consisting of methanol, ethanol, propanol, isopropanol, acetone, methylethylketone and mixtures thereof so as to dehydrate said material, and subsequently removing said solvent at a pressure of between 0.1 bar and 1.0 bar, the final water content of said material being from 5 to 10%.
Claim 13
Independent Claim
85 words
A method of preserving material suitable for use as a human transplant comprising contacting a biological collagenous material without subdivision thereof at ambient temperatures in the absence of added water with fresh amounts of water-miscible organic solvent selected from the group consisting of methanol, ethanol, propanol, isopropanol, acetone, methylethylketone and mixtures thereof so as to dehydrate said material, and subsequently removing said solvent at a pressure of between 0.1 bar and 1.0 bar, the final water content of said material being from 5 to 10%.
Claim 14
Dependent Claim
13 words
The method of claim 9 wherein said biological collagenous material is dura mater.
Claim 15
Dependent Claim
24 words
The method of claim 10 wherein, as a final step, the dehydrated dura mater is packaged in moisture-proof bags and irradiated with 2.5 Mrad.
Claim 16
Dependent Claim
85 words
A biological collagenous material which has been preserved for use as a human transplant by contacting said material without subdivision thereof at ambient temperatures in the absence of added water with fresh amounts of water-miscible organic solvent selected from the group consisting of methanol, ethanol, propanol, isopropanol, acetone, methylethylketone and mixtures thereof so as to dehydrate said material, and subsequently removing said solvent at a pressure of between 0.1 bar and 1.0 bar, the final water content of said material being from 5 to 10%.
Claim 17
Dependent Claim
85 words
A biological collagenous material which has been preserved for use as a human transplant by contacting said material without subdivision thereof at ambient temperatures in the absence of added water with fresh amounts of water-miscible organic solvent selected from the group consisting of methanol, ethanol, propanol, isopropanol, acetone, methylethylketone and mixtures thereof so as to dehydrate said material, and subsequently removing said solvent at a pressure of between 0.1 bar and 1.0 bar, the final water content of said material being from 5 to 10%.
Claim 18
Dependent Claim
13 words
The product of claim 12 wherein said biological collagenous material is dura mater.
Claim 19
Dependent Claim
27 words
The product of claim 13 wherein, as a final step in its preservation, the dehydrated dura mater is packaged in moisture-proof bags and irradiated with 2.5 Mrad.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-11-16 | 1985-05-18 | 1985-11-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-11-16 | 1989-05-18 | 1989-11-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-11-16 | 1993-05-18 | 1993-11-17 | $7700.00 | Window Closed / Lapsed |