US6273901B1
Expired / Lapsed
US
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Thrombosis filter having a surface treatment
Assignee: Boston Scientific Scimed Inc
•
Filing: 1999-08-10
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Granted: 2001-08-14
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Expires: 2019-08-10
Abstract
Abstract A thrombosis filter configured for placement within a blood vessel lumen. The thrombosis filter of the present invention includes a body element, a plurality of struts, and a surface treatment. The surface treatment, comprised in part of an anti-proliferative or anti-angiogenic drug, is applied to portions of the thrombosis filter in order to regulate neointimal growth around the thrombosis filter and its anchor elements. The thrombosis filter may further contain a first and a second surface treatment layer. The first surface treatment layer possesses endothelial cell growth enhancing properties, while the second surface treatment layer includes the anti-proliferative or anti-angiogenic drug. The surface treatment may alternatively be applied to a substrate, which in turn is applied to the filter.
Inventors
- 👤 Forrest D. Whitcher
- 👤 Alan Kaganov
- 👤 Sally C. Thornton
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 02:48
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/01; A61F2/0105; A61F2002/016; A61F2230/00; A61F2230/0002; A61F2230/0028; A61F2230/005; A61F2230/0063; A61F2230/0067; A61F2230/0073; A61F2230/0078; A61F2230/008; A61F2250/00; A61F2250/0058; A61F2250/0067
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
138 words
A thrombosis filter element for placement within a blood vessel lumen defined by a vessel wall comprising: a body element from which a plurality of struts radiate, the plurality of struts each having a joining end, wherein the joining end of the plurality of struts attach to the body element, the plurality of struts each having a free end, wherein each of the free ends of the plurality of struts contact the blood vessel wall; and a surface treatment covering at least a portion of the thrombosis filter, wherein the surface treatment comprises two layers, a first surface treatment layer located between a second surface treatment layer and the portion of the thrombosis filter, the first surface treatment layer having properties which enhance endothelial cell growth, and the second surface treatment layer including an anti-proliferative or anti-angiogenic drug.
Claim 2
Dependent Claim
138 words
A thrombosis filter element for placement within a blood vessel lumen defined by a vessel wall comprising: a body element from which a plurality of struts radiate, the plurality of struts each having a joining end, wherein the joining end of the plurality of struts attach to the body element, the plurality of struts each having a free end, wherein each of the free ends of the plurality of struts contact the blood vessel wall; and a surface treatment covering at least a portion of the thrombosis filter, wherein the surface treatment comprises two layers, a first surface treatment layer located between a second surface treatment layer and the portion of the thrombosis filter, the first surface treatment layer having properties which enhance endothelial cell growth, and the second surface treatment layer including an anti-proliferative or anti-angiogenic drug.
Claim 3
Dependent Claim
14 words
A thrombosis filter element according to claim 1 , wherein the drug is taxol.
Claim 4
Dependent Claim
14 words
A thrombosis filter element according to claim 1 , wherein the drug is non-thrombogenic.
Claim 5
Dependent Claim
36 words
A thrombosis filter element according to claim 1 , wherein the second surface treatment layer is dissolvable, wherein the dissolving rate may be varied depending upon the structure and composition of the second surface treatment layer.
Claim 6
Dependent Claim
49 words
A thrombosis filter element according to claim 1 , wherein the surface treatments incorporate, respectively, the anti-proliferative or anti-angiogenic drug and the endothelial cell growth enhancer with a bio-compatible polymeric material, or a combination of the surface treatment layers with or without the incorporation of the bio-compatible polymeric material.
Claim 7
Dependent Claim
32 words
A thrombosis filter element according to claim 1 , wherein the first and second surface treatment layers cover the plurality of free ends of the struts in contact with the vessel wall.
Claim 8
Dependent Claim
46 words
A thrombosis filter element according to claim 1 , wherein the surface treatments, or some combination of the first surface treatment layer and the second surface treatment layer, are coated upon at least a portion of the thrombosis filter element through a dipping or spraying process.
Claim 9
Dependent Claim
168 words
A thrombosis filter element for placement within a blood vessel lumen comprising: a body element, wherein the body element is aligned parallel with a longitudinal axis of the blood vessel lumen, wherein from the body element a plurality of struts radiate, the plurality of struts comprised of a bio-compatible material selected from the group consisting of nitinol, stainless steel, tantalum, gold, silicone, and combinations thereof, wherein the plurality of struts extend outward from the body element, including joining ends of the plurality of struts attached to the body element, and free ends, wherein a portion of the free ends of the plurality of struts engage the blood vessel wall; and an anti-proliferative or anti-angiogenic drug constituting a surface treatment covering at least a portion of the thrombosis filter element, wherein the surface treatment may cover the entire or only discrete regions of the thrombosis filter element, wherein the surface treatment incorporates the anti-proliferative or anti-angiogenic drug with a biocompatible polymeric material, wherein the bio-compatible polymeric material is biodegradable.
Claim 10
Dependent Claim
168 words
A thrombosis filter element for placement within a blood vessel lumen comprising: a body element, wherein the body element is aligned parallel with a longitudinal axis of the blood vessel lumen, wherein from the body element a plurality of struts radiate, the plurality of struts comprised of a bio-compatible material selected from the group consisting of nitinol, stainless steel, tantalum, gold, silicone, and combinations thereof, wherein the plurality of struts extend outward from the body element, including joining ends of the plurality of struts attached to the body element, and free ends, wherein a portion of the free ends of the plurality of struts engage the blood vessel wall; and an anti-proliferative or anti-angiogenic drug constituting a surface treatment covering at least a portion of the thrombosis filter element, wherein the surface treatment may cover the entire or only discrete regions of the thrombosis filter element, wherein the surface treatment incorporates the anti-proliferative or anti-angiogenic drug with a biocompatible polymeric material, wherein the bio-compatible polymeric material is biodegradable.
Claim 11
Dependent Claim
40 words
A thrombosis filter element according to claim 8 , wherein the addition of the surface treatment alters the overall structural properties of the thrombosis filter element, wherein the surface treatment adds rigidity thereby enhancing performance of the thrombosis filter element.
Claim 12
Dependent Claim
163 words
A thrombosis filter element for placement within a blood vessel lumen comprising: a body element, wherein the body element is aligned parallel with a longitudinal axis of the blood vessel lumen, wherein from the body element a plurality of struts radiate, the plurality of struts comprised of a bio-compatible material selected from the group consisting of nitinol, stainless steel, tantalum, gold, silicone, and combinations thereof, wherein the plurality of struts extend outward from the body element, including joining ends of the plurality of struts attached to the body element, and free ends, wherein a portion of the free ends of the plurality of struts engage the blood vessel wall; and an anti-proliferative or anti-angiogenic drug constituting a surface treatment covering at least a portion of the thrombosis filter element, wherein the surface treatment may cover the entire or only discrete regions of the thrombosis filter element, wherein the surface treatment is applied to a substrate which covers the portion of the thrombosis filter.
Claim 13
Dependent Claim
163 words
A thrombosis filter element for placement within a blood vessel lumen comprising: a body element, wherein the body element is aligned parallel with a longitudinal axis of the blood vessel lumen, wherein from the body element a plurality of struts radiate, the plurality of struts comprised of a bio-compatible material selected from the group consisting of nitinol, stainless steel, tantalum, gold, silicone, and combinations thereof, wherein the plurality of struts extend outward from the body element, including joining ends of the plurality of struts attached to the body element, and free ends, wherein a portion of the free ends of the plurality of struts engage the blood vessel wall; and an anti-proliferative or anti-angiogenic drug constituting a surface treatment covering at least a portion of the thrombosis filter element, wherein the surface treatment may cover the entire or only discrete regions of the thrombosis filter element, wherein the surface treatment is applied to a substrate which covers the portion of the thrombosis filter.
Claim 14
Dependent Claim
20 words
A thrombosis filter according to claim 10 , wherein the substrate is disposed about the free ends of the struts.
Claim 15
Dependent Claim
16 words
A thrombosis filter according to claim 11 , wherein the substrate comprises a plurality of pads.
Claim 16
Dependent Claim
27 words
A thrombosis filter according to claim 12 , wherein the pads each include a hole, and wherein the struts are disposed in the holes of the pads.
Claim 17
Dependent Claim
16 words
A thrombosis filter according to claim 11 , wherein the substrate comprises a plurality of tubes.
Claim 18
Dependent Claim
27 words
A thrombosis filter according to claim 14 , wherein the tubes each include a lumen, and wherein the struts are disposed in the lumens of the tubes.
Claim 19
Dependent Claim
25 words
A thrombosis filter according to claim 11 , wherein the substrate comprises a band surrounding the struts when the filter is in a collapsed configuration.
Claim 20
Dependent Claim
25 words
A thrombosis filter according to claim 16 , wherein the band separates into a plurality of segments when the filter is in an expanded configuration.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2004-08-13 | 2005-02-12 | 2005-08-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2008-08-13 | 2009-02-12 | 2009-08-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2012-08-13 | 2013-02-12 | 2013-08-14 | $7700.00 | Window Closed / Lapsed |